Patents Assigned to Dott Research Laboratory
  • Nasally administrable compositions
    Patent number: 6589559
    Abstract: A nasally administrable composition of a physiologically active substance, wherein an effective amount of said physiologically active substance is dispersed homogeneously in and adsorbed homogeneously onto a fine powdery form of a cereal, thereby enhancing the absorption of the physiologically active substance into a body via the nasal route. Examples of the cereal are rice, wheat, soybean, corn, foxtail, millet, buckwheat and the like, especially rice, and the physiologically active substance is a physiologically active peptide.
    Type: Grant
    Filed: October 17, 2000
    Date of Patent: July 8, 2003
    Assignee: DOTT Research Laboratory
    Inventor: Akira Yanagawa
  • Nasally administrable compositions
    Patent number: 6197328
    Abstract: A nasally administrable composition which contains physiologically active compounds such as insulin, calcitonin, prostaglandin (PG) derivatives, monoclonal antibodies or interleukin derivatives (IL), and is enhanced in the in vivo absorbability of the physiologically active compound when administered nasally. The compositions are prepared by mixing fine particulate of the physiologically active compound with fine particulate of carrier having a mean particle size from 15 &mgr;m to 300 &mgr;m, and particle surface area from 0.1 to 0.4 m2/g, a which adhere to the mucous membrane of the nasal cavity, and HPC—H as absorption accelerator.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: March 6, 2001
    Assignee: Dott Research Laboratory
    Inventor: Akira Yanagawa
  • Nasally administrable compositions containing physiologically active peptides
    Patent number: 5908824
    Abstract: A nasally administrable composition having a physiologically active peptide dispersed homogeneously in and adsorbed homogeneously onto a unique carrier. The composition contains an effective amount of physiologically active peptide dispersed homogeneously in and adsorbed homogeneously onto a mucosa protecting and/or tissue repairing agent, e.g., gefarnate, aceglutamide aluminum, sucralfate, L-glutamine, sofalcone, teprenone, plaunotol, rebamipide, aldioxa, cetraxate or troxipide.
    Type: Grant
    Filed: October 16, 1996
    Date of Patent: June 1, 1999
    Assignee: Dott Research Laboratory
    Inventor: Akira Yanagawa
  • Nasally administrable compositions
    Patent number: 5603943
    Abstract: A nasally administrable composition having a physiologically active substance dispersed homogeneously in and adsorbed homogeneously onto a unique carrier. The nasally administrable composition contains a physiologically effective amount of the physiologically active substance having a molecular weight of not more than 40,000, dispersed homogeneously in and adsorbed homogeneously onto physiologically acceptable powdery or crystalline polyvalence metal compound carrier.The metal compound carrier is selected from aluminum compound, calcium compound, magnesium compound, silicon compound, iron compound and zinc compound.The composition is nasally administrable in powdery form.
    Type: Grant
    Filed: April 26, 1995
    Date of Patent: February 18, 1997
    Assignee: Dott Research Laboratory
    Inventor: Akira Yanagawa
  • Nasally administrable peptide compositions on hydroxyapatite carriers
    Patent number: 5574006
    Abstract: A physiologically active peptide composition having a physiologically active peptide dispersed homogeneously in and adsorbed homogeneously onto a unique carrier. The physiologically active peptide composition contains a physiologically effective amount of the physiologically active peptide dispersed homogeneously in and adsorbed homogeneously onto hydroxyapatite. The composition is nasally administrable in powdery form.
    Type: Grant
    Filed: October 18, 1994
    Date of Patent: November 12, 1996
    Assignee: Dott Research Laboratory
    Inventor: Akira Yanagawa