Abstract: A method for adhering a first substrate to a second substrate using a double sided adhesive device based on silicone gels. The method is particularly useful for adhering a medical prosthesis to a human or animal body.

Abstract: A composition comprising 1-25 wt. % of a silicone gum, 1-40 wt. % of a silicone fluid having a viscosity of 10 to 60,000 mm2/sec, 1-35 wt. % of a silicone wax and 20-90 wt. % of a volatile silicone fluid having a viscosity up to and including 5 mm2/s at 25° C. can be used for the treatment of scars resulting from injury or surgery.

Abstract: A medical device has a biocompatible coating made by reacting a reactive polysiloxane, an acetoxysilane crosslinking agent, a reinforcing silica and a metal catalyst. Such devices cause decreased reactions when they come into contact with a human or animal body or its blood, fluids or other biological membranes.

Abstract: The invention relates to a process for making a controlled release device suitable for introduction into a human or animal body. The process comprises coextruding a continuous external body comprising a silicone elastomer and one or more elements comprising a synthetic pharmaceutical agent within the continuous external body.

Abstract: A method of manufacturing a controlled-release device is described. The method comprises taking a hollow tubular element which is permeable to the active substance to be released and injecting it with at least two plugs of hardenable material. These plugs form partitions which block the hollow tubular element and are spaced apart to form at least one discrete hollow chamber. The hardenable material is then hardened and an active substance is introduced into at least one of the discrete hollow chambers.

Abstract: A process is disclosed for making devices which release active material, e.g. a drug, at a controlled rate, which device comprises a closed container and the active material. The device is made by first making a hollow envelope, e.g. by extrusion or moulding, followed by introducing the active material into the void of the envelope. The device may have a ring or cylindrical form.

Abstract: The invention concerns a sustained release formulation comprising an agent (A) which is to be released and a vehicle (B) therefor.The vehicle comprises a hydrophilic component such as a polyhydroxylated organic substance such as a polyethylene glycol, glycerol, sorbitol, mannitol or lactose and curable silicone composition which is capable of curing at ambient temperature and contains a polysiloxane having alkylhydrogen units, a polysiloxane having unsaturated groups and a platinum or rhodium catalyst. The formulation may be applied to the human or animal body or a cavity in the latter to cure in situ to give a dressing capable of sustained release of the therapeutic or diagnostic agent (A) to the body.The invention is applicable in the field of pharmacy.

Abstract: Free-flowing granular compositions principally for use in treatment of gastric disorders comprise (A) titanium dioxide having a particle size within the range from 10 nanometers to 60 nanometers and a specific BET (nitrogen) surface area of at least 30 m.sup.2 /g in combination with (B) an organopolysiloxane antifoam agent (for example a mixture of from 90 to 99 percent by weight of a polydiorganosiloxane and from 1 to 10 percent by weight of a finely-divided silica having a surface area to weight ratio of at least 50 m.sup.2 /g), (B) being present in a proportion of from 30 to 70 percent by weight calculated on the combined weight of (A) and (B). The compositions may contain from 40 to 60 percent of (B) based on the combined weight of (A) and (B). They may also contain an antacid or other medicament, glycerol, an effervescent agent and/or a disintegrant component.

Abstract: The apparatus is adapted to be held in one hand of an operator from mixing components of a composition packaged as two or more individually stable components of substantially equal volume and viscosity each in a receptacle having a closure made of a material which can be ruptured, and to dispense the mixed composition by a manual operation. The device comprises a mixing housing, separate chambers for the receptacles, piercing means for piercing the receptacles, plunger means for expelling a component from the chamber into the mixing region, a mixing element in the mixing region, and a passageway which contains means for actuating the mixing element and through which the mixed composition may be expelled from the mixing region.

Abstract: A method of accelerating the permeation of drugs in topical and transdermal delivery of a drug in which a drug is applied to the skin in combination with organosilicon compounds which are carboxyalkyl functional polysiloxanes and alkylsulphoxide functional polysiloxanes. The organosilicon compound may be applied to the skin neat or in the form of a solvent solution containing the organosilicon compound.

Abstract: The specification describes and claims a flexible article intended for inflation in the human or animal body, e.g. a prosthesis or tissue expander, which comprises an envelope having upon its surface a receptor structure adapted to receive a portion of a tool intended for inserting the article into a subcutaneous cavity in the body and capable of releasing the tool when the article has been inserted subcutaneously in the body. Preferably the receptor structure comprises an abutment portion against which an end portion of the tool may bear during insertion of the article into the cavity and location indicator whereby the end portion of the tool is restrained in contact with the abutment portion during the insertion. The preferred article is an elongate tissue expander and the receptor structure is located adjacent an end portion of the envelope with its abutment portion located nearer to the end portion than the location means. Tools for use with articles of the invention are described.

Abstract: A multi-component foamable silicone composition is described and claimed which is capable of curing quickly at 20.degree. C. to provide a low density foamed mass. The composition comprises (A) one or more polydiorganosiloxanes having not less than three alkyl-hydrogensiloxane units per molecule, (B) one or more polydiorganosiloxanes having not less than two alkenyl-siloxane units (C) a liquid alcohol, (D) a fluorinated silicone foam stabilizing material and (E) a platinum catalyst for promoting reaction between the components. The composition may be packaged as two or more individually stable parts of substantially equal volume and viscosity each in a receptacle of material which is adapted to be opened by rupture so as to release the components for admixture. The composition is intended for use in forming a foam medical dressing by dispensing onto a surface e.g. an open wound and allowing the composition to cure at room temperature.

Abstract: Non-friable siloxane gels which can be used for gel dressings and in medical prostheses are made from compositions comprising (A) alkenyl-containing polydiorganosiloxanes; (B) hydrosilicon compounds having at least 3 Si-H groups; (C) SiH end-blocked polydiorganosiloxanes and (D) a catalyst. These compositions cure rapidly at room temperature having a ratio (RHAlk) of SiH:Si-Alkenyl of from 3:1 to 20:1, the percentage of silicon-bonded H atoms provided by (C) not being less than 81.36-(3.6.times.RHAlk) and having a value of from 10% to 90%.

Abstract: The invention relates to silicone foams.It concerns a silicone foam composition consisting of two or more components, the said composition being capable of rapid cure at 20.degree. C. on mixing its components, to give a foamed mass having a density of less than 200 kg/m.sup.3, characterised in that it comprises (A) one or more polysiloxanes having at least three alkylhydrogensiloxane units per molecule, (B) one or more polydiorganosiloxanes having at least two siloxane units of the formula ##EQU1## in which R represents a monovalent hydrocarbon group containing from 1 to 20 carbon atoms, Q represents a hydroxylated alkylene or alkoxylene chain, a has a value of 0, 1 or 2 and the value of b is 1 or 2 and c is a platinum catalyst for promoting the reaction between the components.Useful for the production of medical dressings.

Abstract: The specification describes and claims a method of making therapeutic rings from a curable silicone rubber based composition. The rings are capable of controlled release of the therapeutic agent in the human or animal body. The method includes the steps of:(i) extruding a first composition comprising a therapeutic agent and a first elastomer-forming silicone composition to provide a core;(ii) extruding a second composition comprising a second elastomer-forming silicone composition to provide a sheath enclosing the core;(iii) bringing together end portions of a piece of extruded core and sheath to form a ring,(iv) effecting crosslinking of the extruded core, and(v) effecting crosslinking of the extruded sheath.

Abstract: The invention relates to chambers which are sealed against ingress of water and are provided with an element through which air may permeate to equalize pressures of air inside and outside the chamber. The element is of a foamed silicone and has a cellular fine pored layer of predominantly open cells having a skin to be contacted by air outside the chamber. Examples of chambers described and claimed are a vehicle horn and a vehicle headlight.

Abstract: The specification is directed to making noncellular dressings such as gelatinous wound dressings. According to the invention medical and surgical dressings are made by use of packages which may be held in the hand, and which contain the components of two part curable polysiloxane compositions in such a manner that the component may be mixed in predetermined proportions and dispensed therefrom under the influence of propellant gas. The method avoids the need for manual mixing of such compositions during production of dressings.

Abstract: The specification is directed to polysiloxane foams. There are disclosed compositions capable of curing at room temperature which comprise a hydroxypolysiloxane, an alkylhydrogen polysiloxane, a tin compound as catalyst and finely divided filler. According to the invention storage stability of these foam forming polysiloxane compositions is improved by use as filler of silica which has been pretreated to render is hydrophobic. The subject compositions may comprise two components which do not require individual mixing prior to mixing together of the components. The compositions may be packaged in any convenient manner. The compositions may be used for a variety of purposes, for example to provide medical dressings.