Patents Assigned to Dow Global Technologies Incorporated
  • Processes for improved disulfide bond formation in recombinant systems
    Publication number: 20070238153
    Abstract: Methods and prokaryotic expression systems for producing recombinant disulfide bond-containing proteins are described including increasing the level of at least one redox cofactor in the cell to enhance disulfide bond formation are disclosed. Processes of increasing levels of redox cofactors include media supplementation and genetic modification of the host cell. The process can yield increased levels of soluble or active protein, or can assist the proper processing of recombinant proteins in expression systems.
    Type: Application
    Filed: April 6, 2007
    Publication date: October 11, 2007
    Applicant: Dow Global Technologies Incorporated
    Inventor: Charles Squires