Abstract: An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.
Abstract: The present invention provides stable aqueous doxycycline aqueous solutions suitable for pharmaceutical, especially ophthalmic, use. The doxycycline aqueous solutions have a pH ranging from 4.5-8, and contain an antioxidant and a stabilizer such as caffeine, creatine or mixtures thereof. The solutions have improved lifetimes and can be used topically.
Type:
Application
Filed:
January 20, 2011
Publication date:
July 26, 2012
Applicants:
Dow Pharmaceutical Sciences, Inc., Advanced Vision Research, Inc.
Inventors:
JEFFREY P. GILBARD, ELIZABETH GILBARD, GREGORY FIELDSON, ROBERT B. HUSON
Abstract: A solid dosage form for oral administration comprising azithromycin in an amount below that which causes gastrointestinal side effects, which dosage form is a controlled release dosage form.
Type:
Application
Filed:
January 25, 2012
Publication date:
May 17, 2012
Applicant:
Dow Pharmaceutical Sciences, Inc.
Inventors:
Radhakrishnan Pillai, Pramod Sarpotdar, David W. Osborne, Gordon J. Dow
Abstract: Powder containing benzoyl peroxide is readily wetted by contacting the powder with a liquid containing one or more of a polyol, a polyol, ether, and a low-carbon organic alcohol.
Abstract: Azithromycin has increased efficacy in treating acne and other skin conditions when administered systemically at low doses, below those previously known to produce a clinical antibiotic effect.
Type:
Grant
Filed:
September 4, 2008
Date of Patent:
March 27, 2012
Assignee:
Dow Pharmaceutical Sciences, Inc.
Inventors:
Gordon Jay Dow, Bhaskar Chaudhuri, David Wade Osborne, Barry Calvarese
Abstract: A solid dosage form for oral administration comprising azithromycin in an amount below that which causes gastrointestinal side effects, which dosage form is a controlled release dosage form.
Type:
Grant
Filed:
December 17, 2007
Date of Patent:
February 28, 2012
Assignee:
Dow Pharmaceutical Sciences, Inc.
Inventors:
Radhakrishnan Pillai, Pramod Sarpotdar, David W. Osborne, Gordon J. Dow
Abstract: Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, which composition has a surface tension of 40 dynes/cm or less and has continuing spreadability, and which composition is effective in treating a disorder of the nail or nail bed.
Abstract: Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, which composition has a surface tension of 40 dynes/cm or less and has continuing spreadability, and which composition is effective in treating a disorder of the nail or nail bed.
Abstract: The combination of any two of a polyol, a polyol ether, and a low carbon organic alcohol provides a synergistic effect on the solubility of azole compounds, such as metronidazole, in aqueous fluid.
Abstract: Methionine is an effective antioxidant for polypeptides having an amino acid sequence lacking methionine. Compositions containing polypeptides having an amino acid sequence that is free of methionine residues are stabilized from oxidative degradation by combining methionine in the composition in an amount effective to inhibit oxidation of the polypeptide.
Abstract: An emulsion for topical application to the skin containing a high molecular weight emulsifier and substantially no emulsifiers of a molecular weight less than 100 kD. The emulsion may be used to prevent or treat dermatoses and may additionally contain pharmaceutically active ingredients.
Abstract: An aqueous solution of metronidazole in which the concentration of metronidazole is higher than 0.75%. The solution contains a combination of solubility-enhancing agents, one of which is a cyclodextrin such as beta-cyclodextrin and the second is niacin or niacinamide. Methods of manufacture and therapeutic use of the solution are disclosed.
Abstract: Increased compliance in the use of topical sunscreens is obtained by combining a topical sunscreen agent in a formulation containing an antibacterial medication such as azelaic acid or an antibiotic.
Type:
Grant
Filed:
June 27, 2007
Date of Patent:
February 5, 2008
Assignee:
Dow Pharmaceutical Sciences
Inventors:
Arturo Angel, David W. Osborne, Gordon J. Dow
Abstract: Increased compliance in the use of topical sunscreens is obtained by combining a topical sunscreen agent in a formulation containing an antibacterial medication such as azelaic acid or an antibiotic.
Type:
Grant
Filed:
March 29, 2006
Date of Patent:
August 7, 2007
Assignee:
Dow Pharmaceutical Sciences
Inventors:
Arturo Angel, David W. Osborne, Gordon J. Dow
Abstract: An aqueous solution of metronidazole in which the concentration of metronidazole is higher than 0.75%. The solution contains a combination of solubility-enhancing agents, one of which is a cyclodextrin such as beta-cyclodextrin and the second is a compound other than a cyclodextrin. Methods of manufacture and therapeutic use of the solution are disclosed.
Abstract: A non-irritating skin cleanser that contains water, a non-ionic surfactant, and a glyceryl monoester of a fatty acid. The skin cleanser is especially useful for cleansing irritated, diseased, damaged, or sensitive skin. The cleanser is especially useful for cleansing hands.
Abstract: An aqueous solution of metronidazole in which the concentration of metronidazole is higher than 0.75%. The solution contains a combination of solubility-enhancing agents, one of which is a cyclodextrin such as beta-cyclodextrin and the second is a compound other than a cyclodextrin. Methods of manufacture and therapeutic use of the solution are disclosed.
Abstract: A composition is provided that has a viscosity of less than about 15,000 cP and a pH of about 3.0 to 9.0 for treating a skin disorder in a human subject. The composition is a lotion that consists essentially of (a) a therapeutically-effective amount of at least one compound useful for treating such disorder, (b) a pharmaceutically-acceptable, lightly cross-linked polyacrylic acid polymer compatible with the compound, (c) a pharmaceutically acceptable base to adjust pH, (d) up to about 25% ww of at least one water miscible solvent, (e) optionally a preservative, (f) water, and (g) an oil phase component and suitable surfactant. The composition is useful for treating an inflammatory skin disorder, acne, or rosacea.
Type:
Grant
Filed:
March 8, 2002
Date of Patent:
February 11, 2003
Assignee:
Dow Pharmaceutical Sciences
Inventors:
Gordon J. Dow, Robert W. Lathrop, Debra A. Dow
Abstract: An aqueous solution of metronidazole in which the concentration of metronidazole is higher than 0.75%. The solution contains the solubility enhancer hydroxypropyl-betacyclodextrin and may additionally contain niacinamide. Methods of manufacture and therapeutic use of the solution are disclosed.
Type:
Grant
Filed:
July 13, 2000
Date of Patent:
October 22, 2002
Assignee:
Dow Pharmaceutical Sciences
Inventors:
Yunik Chang, Gordon J. Dow, Arturo Angel