Abstract: Disclosed are solid oral controlled-release pharmaceutical compositions of antibiotics/ antibacterials comprising a core consisting of a complex monolithic matrix comprising at least one low/medium viscosity hydroxypropyl methylcellulose, at least one medium/high viscosity hydroxypropyl methylcellulose, one or more methacrylic polymers or copolymers and/or cellulose acetate phthalate and/or hydroxypropyl methylcellulose acetate succinate or shellac, and an outer coating of said core consisting of a layer comprising ethylcellulose, or of a gastroresistant layer or of a layer comprising ethylcellulose coated in turn with gastroresistant polymers. The compositions of the invention enable the frequency of administration to be reduced, and the release of the medicament in particular sites of the gastrointestinal tract to be controlled.
Type:
Application
Filed:
March 17, 2021
Publication date:
June 15, 2023
Applicant:
DPL PHARMA S.P.A.
Inventors:
Massimo Pedrani, Chiara Conti, Salvatore Agostino Giammillari, Giuseppe Maccari
Abstract: The present invention relates to solid oral pharmaceutical compositions for chronotropic administration of sartans, consisting of a monolithic matrix core comprising at least one low/medium viscosity hydroxypropyl methylcellulose, at least one medium/high viscosity hydroxypropyl methylcellulose, one or more methacrylic polymers or copolymers and/or cellulose acetate phthalate and/or hydroxypropyl methylcellulose acetate succinate or shellac and an outer coating of said core consisting of a layer comprising ethyl cellulose, a gastroresistant layer, or a layer comprising ethylcellulose coated in turn with gastroresistant polymers.
Type:
Application
Filed:
December 12, 2019
Publication date:
March 3, 2022
Applicant:
DPL PHARMA S.P.A.
Inventors:
Massimo Pedrani, Chiara Conti, Salvatore Agostino Giammillari, Giuseppe Maccari
Abstract: The present invention relates to solid oral pharmaceutical compositions for chronotropic administration of mesalazine, the salts or derivatives thereof, consisting of a complex monolithic matrix core comprising at least one low/medium viscosity hydroxypropyl methylcellulose, at least one medium/high viscosity hydroxypropyl methylcellulose, one or more methacrylic polymers or copolymers and/or cellulose acetate phthalate and/or hydroxypropyl methylcellulose acetate succinate or shellac, and an outer coating of said core consisting of a layer comprising ethylcellulose, or of a gastroresistant layer or of a layer comprising ethylcellulose coated in turn with gastroresistant polymers.
Type:
Application
Filed:
December 12, 2019
Publication date:
February 17, 2022
Applicant:
DPL PHARMA S.P.A.
Inventors:
Massimo Pedrani, Chiara Conti, Salvatore Agostino Giammillari, Giuseppe Maccari
Abstract: The present invention relates to solid oral pharmaceutical compositions for chronotropic administration of dipeptidyl peptidase IV inhibitors consisting of a monolithic matrix core comprising at least one low/medium viscosity hydroxypropyl methylcellulose, at least one medium/high viscosity hydroxypropyl methylcellulose, one or more methacrylic polymers or copolymers and/or cellulose acetate phthalate or shellac and an outer coating of said core consisting of a layer comprising ethylcellulose, a gastroresistant layer, or a layer comprising ethylcellulose coated in turn with gastroresistant polymers.
Type:
Application
Filed:
December 12, 2019
Publication date:
February 17, 2022
Applicant:
DPL PHARMA S.P.A.
Inventors:
Massimo Pedrani, Chiara Conti, Salvatore Agostino Giammillari, Giuseppe Maccari
Abstract: The present invention relates to solid oral controlled-release pharmaceutical compositions comprising a core consisting of a complex monolithic matrix comprising at least one low/medium viscosity hydroxypropyl methylcellulose, at least one medium/high viscosity hydroxypropyl methylcellulose, one or more methacrylic polymers or copolymers and/or cellulose acetate phthalate and/or hydroxypropyl methylcellulose acetate succinate or shellac, and an outer coating of said core consisting of a layer comprising ethylcellulose, or of a gastroresistant layer or of a layer comprising ethylcellulose coated in turn with gastroresistant polymers.
Type:
Application
Filed:
December 12, 2019
Publication date:
January 20, 2022
Applicant:
DPL PHARMA S.P.A.
Inventors:
Massimo Pedrani, Chiara Conti, Salvatore Agostino Giammillari, Giuseppe Maccari