Abstract: Antibody-based methods of detecting of molecules interacting with a target molecule, such as a nuclear or cytoplasmic protein, in a fixed and, optionally, permeabilized cell or tissue sample. In one example, the target molecule is bound by a primary antibody, and a secondary, peroxidase-conjugated antibody, then binds to the primary antibody. The peroxidase may also be conjugated the primary antibody. Biotin tyramide is added to the sample, and the peroxidase generates short-lived intermediates resulting in biotinylation of molecules adjacent to the peroxidase. Biotinylated molecules can be isolated from the sample by affinity interaction with avidin- or streptavidin, resulting in a fraction containing biotinylated molecules that are located in the sample in proximity to the target molecule. The fraction can be analyzed by mass-spectroscopy, Western blotting, sequencing and other techniques.

Abstract: This invention discloses a capacitive touch screen comprising an Indium Tin Oxide (ITO) tempered glass and an ITO film both of which are adhesively laminated integrally together via an optical adhesive. The ITO tempered glass comprises a glass substrate comprising a viewing window area and a non-viewing window area, a black ink layer disposed on a first lateral surface of the glass substrate and printed in a corresponding area thereof to the non-viewing window area, an ITO circuit plating layer covering the black ink layer and the viewing window area. The present invention utilizes the optical adhesive to directly adhesively laminate the ITO tempered glass and the ITO film, and as a result, its lamination structure is able to simplify. Furthermore, the present invention not only effectively reduces its integral thickness thereof, but also has simple production techniques, a low cost of manufacturing, and a high yield rate of production.

Abstract: A topical pharmaceutical aerosol foam containing liquid silicones to enhance cosmetic elegance. Although liquid silicones are inherent defoamers, a high quality, stable foam is produced.

Abstract: The present invention is directed to water-in-oil (W/O) emulsion compositions containing gellan gum which provide an enhanced rate of release of active ingredients for delivery to the skin or mucosa.

Abstract: The present invention provides for the preparation of stable surfactant-free dispersions of hydrophobic substances in low viscosity hydrophilic glyceryl polyacrylate or glyceryl polymethacrylate fluids, and topical vehicles formulated with the dispersions.

Abstract: The invention relates to a ball-shaped puzzle comprising a spherical support element (1; 31) and a plurality of movable puzzle elements (16; 33) which all have substantially the same size and shape, the movable puzzle elements (16; 33) being slidably engaged in a trajectory (2; 32) on the outside of the spherical support element (1; 31), the trajectory (2; 32) defining a plurality of predetermined positions on the outside of the spherical support element (1; 31) between which the puzzle elements (16; 33) are movable. The spherical support element (1; 31) comprises a core and a plurality of trajectory forming elements (15; 45-46) which form the trajectory (2; 32), the trajectory forming elements (15; 45-46) being fixed onto the core (13; 43-44) by a snap-fitting arrangement (40-41).

Abstract: The invention relates to a ball-shaped puzzle comprising a spherical support element (1; 31) and a plurality of movable puzzle elements (16; 33) which all have substantially the same size and shape, the movable puzzle elements (16; 33) being slidably engaged in a trajectory (2; 32) on the outside of the spherical support element (1; 31), the trajectory (2; 32) defining a plurality of predetermined positions on the outside of the spherical support element (1; 31) between which the puzzle elements (16; 33) are movable. The spherical support element (1; 31) comprises a core and a plurality of trajectory forming elements (15; 45-46) which form the trajectory (2; 32), the trajectory forming elements (15; 45-46) being fixed onto the core (13; 43-44) by a snap-fitting arrangement (40-41).

Abstract: Novel compounds and compositions containing (R)-3-hydroxybutyrate derivatives are disclosed. The compounds and compositions can be used as nutritional supplements to increase physical performance and as therapeutics to ameliorate symptoms of medical conditions, particularly neurological conditions, such as Alzheimer's and similar conditions. Novel methods for making R-3-hydroxybutyrate derivatives also are disclosed. Exemplary methods employ a supercritical solvent, such as supercritical carbon dioxide, and employ a lipase catlyzed esterification or transesterification reaction to produce the (R)-3-hydroxybutyrate derivatives.

Abstract: A topical pharmaceutical aerosol foam containing liquid silicones to enhance cosmetic elegance. Although liquid silicones are inherent defoamers, a high quality, stable foam is produced.

Abstract: The present invention provides an &agr;-particle-emitting radioisotope chelation complex comprising 225Actinium (225Ac) and 1,4,7,10,13,16-hexaazacyclohexadecane-N,N′,N′,N′,N′,N′-hexaacetic acid (HEHA) (225Ac-HEHA). Also provided is a bifunctional HEHA, and a bifunctional 225Ac-HEHA. The bifunctional HEHA and the bifunctional 225Ac-HEHA can be conjugated to a targeting agent. In view of the above, the present invention provides a method of making HEHA and methods of making a bifunctional HEHA, including a conjugate thereof Also provided are a method of treating disease, a method of treating cancer, a method of decontaminating a sample from 225Ac, a method of decontaminating a person who has been externally contaminated with 225Ac, and a method of detoxifying a person who has internalized 225Ac.