Abstract: The invention relates to a bone substitute (1) comprising A) a container (2) made of a porous casing (4) which is at least partly provided with openings; and B) a plurality of filler elements (5) which are not connected to one another and which are enclosed in the container (2); wherein C) the filler elements (5) consist of interconnected particles with an average diameter Dp; and D) the openings of the casing (4) are interconnected pores or channels with an average diameter of DM.

Abstract: The bone repair material comprises the following components: A) a first granular component with a diameter larger than 20 ?m chosen from the group of: calcium phosphate, calcium pyrophosphate, or calcium sulfate dihydrate; B) a second component chosen from the group of apatite powder with a particle diameter smaller than 1 ?m, (preferably smaller than 100 nm); and B) a third component comprising water or an aqueous solution, whereby C) the volume fraction of the second and third component represents at least 35 volume-% of the total bone repair material.

Abstract: The present invention is directed to an implant device, in particular an implant device placed between bony, cartilaginous or soft tissues or between prosthetic surfaces to restore or create a gap. More particular the present invention is directed to an implant device made from polymeric material and having a stiffness gradient as well as a limited dimensional deformation, wherein the implant device has a stiffness gradient and a limited dimensional deformation and preferably is at least partially anisotropic.

Abstract: Calcium phosphate particles having A) a specific surface area (SSA) larger than 0.1 m2/g; B) a mean diameter smaller than 5 mm; C) a Ca/P molar ratio superior to 0.95; and wherein D) said particles have been subjected as a last processing step to a heat treatment at a temperature superior to 400° C. for a period of time such that the specific surface area (SSA) of said particles after the heat treatment is not decreased by more than 10% compared to the SSA before said heat treatment.

Abstract: A triphasic prosthetic device for repairing or replacing cartilage or cartilage-like tissue. The prosthetic device comprises a highly oriented hollow body component between a superficial random oriented polymer layer and a base component.

Abstract: The present invention is directed to an implant device, in particular an implant device placed between bony, cartilaginous or soft tissues or between prosthetic surfaces to restore or create a gap. More particular the present invention is directed to an implant device made from polymeric material and having a stiffness gradient as well as a limited dimensional deformation, wherein the implant device has a stiffness gradient and a limited dimensional deformation and preferably is at least partially anisotropic.

Abstract: Calcium phosphate particles having A) a specific surface area (SSA) larger than 0.1 m2/g; B) a mean diameter smaller than 5 mm; C) a Ca/P molar ratio superior to 0.95; and wherein D) said particles have been subjected as a last processing step to a heat treatment at a temperature superior to 400° C. for a period of time such that the specific surface area (SSA) of said particles after the heat treatment is not decreased by more than 10% compared to the SSA before said heat treatment.

Abstract: The shaped article is obtained via a cementitious reaction of a particulate composition reactive with water, whereby said reaction is obtained between said composition and an aqueous, liquid or gaseous phase. The particles of the shaped article are present in the form of interlocked particles, whereby the interlocking of said particles is obtained in a 100% water-saturated atmosphere.

Abstract: The method relates to the production of essentially pyrogene-free calcium phosphate starting from one or more calcium phosphate educts having a Ca/P molar ratio in the range of 1.00 to 2.00 and being formed in a pre-determined shape which remains essentially the same during the following procedural steps: A) transforming said educt(s) at least partly to beta-tricalcium phosphate (?-TCP), alpha-tricalcium phosphate (?-TCP), tetracalciumphosphate.(TetCP) or a mixture thereof at a temperature above 600° C.; B) cooling down the material obtained in step A with said ?-TCP, ?-TCP, TetCP or a mixture thereof to below 600° C.; C) reacting the material obtained in step B with said ?-TCP, ?-TCP, TetCP or a mixture thereof with water in gas or liquid phase or in an aqueous Solution at a temperature above room temperature to obtain an end-product which is essentially pyrogene-free.

Abstract: A hydraulic cement based on calcium phosphate for surgical use comprising A) a first component comprising powder particles of calcium phosphate; and B) a second component comprising water. The calcium phosphate comprises anhydrous, amorphous calcium phosphate (ACP) and the ACP is obtained by milling a calcium phosphate synthesized above 500° C. The cement according to the invention has the advantage of being very fast setting compared to prior art calcium phosphate cements. The setting reaction is finished much faster although the initial part of the reaction proceeds at the same speed as with known cements.

Abstract: The bone repair material comprises the following components: A) a first granular component with a diameter larger than 20 ?m chosen from the group of: calcium phosphate, calcium pyrophosphate, or calcium sulfate dihydrate; B) a second component chosen from the group of apatite powder with a particle diameter smaller than 1 ?m, (preferably smaller than 100 nm); and B) a third component comprising water or an aqueous solution, whereby C) the volume fraction of the second and third component represents at least 35 volume-% of the total bone repair material.

Abstract: A triphasic prosthetic device for repairing or replacing cartilage or cartilage-like tissue. The prosthetic device comprises a highly oriented hollow body component between a superficial random oriented polymer layer and a base component.

Abstract: The invention relates to an injection device (1), especially for bone cement, comprising A) a syringe base (3) having a longitudinal axis (2), a front end (6), a connecting piece (8) disposed on the front end (6) and having a coaxial bore (21), and a coaxial cavity (4); B) an injection plunger (5), coaxially displaceable in the cavity (4); and C) a cannula (13) which can be linked with the connecting piece (8) and which has a center bore (14) and a rear end (15). The injection device is characterized in that D) the syringe base (3), on its front end (6), has a transition segment (22) having a bore (9) linking the cavity (4) with the bore (21) in the connecting piece (8), E) the bore (9) in the transition segment (22) and the center bore (14), at least on the rear end (15) of the cannula (13), having the same orthogonal cross-sectional area q relative to the longitudinal axis (2).

Abstract: A hydraulic cement based on calcium phosphate for surgical use comprising A) a first component comprising powder particles of calcium phosphate; and B) a second component comprising water. The calcium phosphate comprises anhydrous, amorphous calcium phosphate (ACP) and the ACP is obtained by milling a calcium phosphate synthesized above 500° C. The cement according to the invention has the advantage of being very fast setting compared to prior art calcium phosphate cements. The setting reaction is finished much faster although the initial part of the reaction proceeds at the same speed as with known cements.

Abstract: A brushite cement for surgical purposes includes a first component including a basic calcium phosphate, a second component including an acidic phosphate, a third component including water, and a fourth component including a source of magnesium used to stabilize an end-product of the setting reaction between the components. The solubility of the source of magnesium is smaller than 100 g/L. The components are chosen in such an amount that (i) the pH of the cement past during setting is lower than 6.0; and (ii) the end-product of the setting reaction comprises dicalcium phosphate dihydrate.

Abstract: The cement for surgical purposes includes three components. The first component includes beta tertiary calciumphosphate &bgr;-Ca3(PO4)2(&bgr;-TCP) particles; and monocalcium phosphate Ca(H2PO4)2(MCPA) or monocalcium phosphate monohydrate Ca(H2PO4).H2O (MCPM) particles or phosphoric acid. The second component includes water. The third component includes particles having an average diameter which is larger than the average diameter of the beta tertiary calciumphosphate &bgr;-Ca3(PO4)2(&bgr;-TCP) particles of the first component. Upon mixing of the three components a hardened mass comprising brushite CaHPO4.2H2O (DCPD) is formed. The &bgr;-TCP particles have a specific surface area of less than 10,000 m2/g and a Ca/P atomic ratio different from 1.50. The component constitutes 1 to 99 volume-percent of the hardened mass.

Abstract: A bioactive surface layer with 0.01 &mgr;m to 5 mm thickness is suitable for a metallic bone implant. The surface layer has the following composition: (A) calcium compounds (CaX) consisting of crystalline calcium phosphate (CaP), calcium apatites (CaAp) and/or calcium carbonate (CaCO3), in a proportion expressed by the following equation: 100% (CaX)=&Sgr;[x % (CaP)+y % (CaCO3)], in which x+y+z=100, 0≦x≦100; 0≦y≦100; 0≦z≦100, and in the form of particles 20 nm to 4 mm; and (B) amorphous or crystalline metal oxide (MeO). The ratio between CAX and MeO in the surface layer can be preferably varied as a result of the specific coating process. The thickness of the surface layer lies between 0.01 &mgr;m and 5 mm and the CaX particles are 20 nm to 4 mm large.