Abstract: The present invention provides a process for the production of a flavanolignan preparation with an improved liberation in comparison with one of the pure flavanolignans, characterized in that a) an aqueous-alcoholic solution of pharmaceutically-acceptable carrier materials and wetting agents is prepared, a flavanolignan is suspended in this solution and the mixture obtained is heated to the boiling temperature in order to form a clear solution or b) a flavanolignan and a wetting agent is suspended in alcohol, the suspension obtained is heated with stirring up to the formation of a clear solution, this is mixed with an aqueous solution of pharmaceutically-acceptable carrier materials and the mixture obtained is heated with stirring until a clear solution is present and that subsequently the clear solution obtained according to a) or b) is concentrated for the formation of a co-precipitate, filtered and the resulting co-precipitate dried in a vacuum.
Abstract: An injection syringe for medical purposes, in which the syringe plunger or a plunger-side end of the syringe cylinder is shaped or provided with components to ensure at least one flow passage or connection between an inner cylindrical space of the cylinder and outer environment, when the plunger is partially, but not completely, introduced into the syringe cylinder.
Type:
Grant
Filed:
July 22, 1988
Date of Patent:
August 28, 1990
Assignee:
Wasserburger Arzneimittelwerk Dr. Madaus GmbH & Co. KG
Abstract: The present invention provides a process for the preparation of substantially pure silibinin from the fruit of Silybum marianum, as well as pharmaceutical compositions containing it for the treatment of diseases of the liver.
Type:
Grant
Filed:
March 18, 1988
Date of Patent:
October 3, 1989
Assignee:
Dr. Madaus GmbH & Co.
Inventors:
Rolf Madaus, Klaus Gorler, Hartwig Soicke