Abstract: Disclosed herein is a method for predicting or diagnosing psychiatric disorders through analyzing skin tissues samples minimally invasive or non-invasively collected. The method disclosed herein makes it possible to diagnose psychiatric disorders through objective biomarkers at a very early age, without giving pain to subjects because of noninvasive or minimally invasive feature of skin sample collection method.

Abstract: The present invention relates to a composition for skin external application. Specifically, a composition for skin external application comprising a stably formed lamella liquid crystal phase can be provided according to the present invention. In addition, according to the present invention, the composition can provide excellent skin moisturizing and skin barrier strengthening effects upon application on the skin, as well as act effectively as an agent for a cannabinoid type 1 receptor, such that it is expected that the present invention can provide a very effective effect for treatment or improvement of skin diseases and mental disorders associated with skin diseases.