Abstract: Neuroactive steroid anaesthetic agents, methods for their preparation and compositions comprising the same are disclosed. Also provided are scaled up and/or GMP methods for preparing neuroactive steroids, such as alfaxalone, alfadolone and alfadolone acetate.
Abstract: The present invention relates generally to the field of drug delivery systems for neuroactive steroid anaesthetic agents. More particularly, anaesthetic and sedative formulations are provided in the form of host/guest preparations comprising one or more neuroactive steroid anaesthetics and a cyclodextrin. Particular cyclodextrins contemplated include sulfoalkyl ether cyclodextrins and modified forms thereof.
Type:
Grant
Filed:
November 1, 2013
Date of Patent:
March 10, 2015
Assignee:
Drawbridge Pharmaceuticals Pty Ltd
Inventors:
Juliet Marguerite Goodchild, Colin Stanley Goodchild, Benjamin James Boyd
Abstract: The present invention relates generally to the field of drug delivery systems for neuroactive steroid anaesthetic agents. More particularly, anaesthetic and sedative formulations are provided in the form of host/guest preparations comprising one or more neuroactive steroid anaesthetics and a cyclodextrin. Particular cyclodextrins contemplated include sulfoalkyl ether cyclodextrins and modified forms thereof.
Type:
Grant
Filed:
January 19, 2011
Date of Patent:
April 15, 2014
Assignee:
Drawbridge Pharmaceuticals Pty Ltd
Inventors:
Juliet Marguerite Goodchild, Colin Stanley Goodchild, Benjamin James Boyd
Abstract: The present invention relates generally to the field of drug delivery systems for neuroactive steroid anaesthetic agents. More particularly, anaesthetic and sedative formulations are provided in the form of host/guest preparations comprising one or more neuroactive steroid anaesthetics and a cyclodextrin. Particular cyclodextrins contemplated include sulfoalkyl ether cyclodextrins and modified forms thereof.
Type:
Application
Filed:
November 1, 2013
Publication date:
March 6, 2014
Applicant:
DRAWBRIDGE PHARMACEUTICALS PTY LTD
Inventors:
JULIET MARGUERITE GOODCHILD, COLIN STANLEY GOODCHILD, BENJAMIN JAMES BOYD