Patents Assigned to DRESDEN UNIVERSITY OF TECHNOLOGY
  • GHRH agonists for islet cell transplantation and function and the treatment of diabetes
    Patent number: 9393271
    Abstract: Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat diabetes. In one embodiment, a method of promoting survival of grafted cells and/or tissues may involve exposing the cells and/or tissues to an effective amount of at least one agonist of GHRH. In some embodiments, the grafted cells and/or tissues may be pancreatic cells. In some embodiments, the grafted cells may be islet cells co-cultured with non-pancreatic cells. In a further embodiment, a method of treating a patient diagnosed with diabetes involves transplanting and/or grafting the islet cells and/or tissues comprising islet cells into a patient, and administering a therapeutically effective amount of at least one agonist of GHRH to the patient. In some embodiments, the islet cells and/or tissues comprising islet cells may be optionally exposed to GHRH and/or at least one agonist of GHRH prior to transplantation into a patient.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: July 19, 2016
    Assignees: University of Miami, The United States of America, Represented by the Department of Veterans Affairs, Dresden University of Technology
    Inventors: Andrew V. Schally, Norman L. Block, Stefan Bornstein, Barbara Ludwig
  • Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets
    Patent number: 8980249
    Abstract: Agonists of growth hormone releasing hormone promote islet graft growth and proliferation in patients. Methods of treating patients comprise the use of these agonists.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: March 17, 2015
    Assignees: University of Miami, Dresden University of Technology
    Inventors: Andrew V. Schally, Barbara Ludwig, Stefan Bornstein, Norman L. Block
  • GHRH AGONISTS FOR ISLET CELL TRANSPLANTATION AND FUNCTION AND THE TREATMENT OF DIABETES
    Publication number: 20140193378
    Abstract: Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat diabetes. In one embodiment, a method of promoting survival of grafted cells and/or tissues may involve exposing the cells and/or tissues to an effective amount of at least one agonist of GHRH. In some embodiments, the grafted cells and/or tissues may be pancreatic cells. In some embodiments, the grafted cells may be islet cells co-cultured with non-pancreatic cells. In a further embodiment, a method of treating a patient diagnosed with diabetes involves transplanting and/or grafting the islet cells and/or tissues comprising islet cells into a patient, and administering a therapeutically effective amount of at least one agonist of GHRH to the patient. In some embodiments, the islet cells and/or tissues comprising islet cells may be optionally exposed to GHRH and/or at least one agonist of GHRH prior to transplantation into a patient.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 10, 2014
    Applicants: UNIVERSITY OF MIAMI, DRESDEN UNIVERSITY OF TECHNOLOGY, U.S.A., REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Andrew V. SCHALLY, Norman L. BLOCK, Stefan BORNSTEIN, Barbara LUDWIG