Abstract: The invention relates to the discovery that HNA-3a and HNA-3b are antigens within a polypeptide sequence that is highly similar to the CTL2 amino acid sequence. This invention provides methods and kits for screening for HNA-3a and HNA-3b specific antibodies, HNA-3a and HNA-3b polypeptides and HNA-3a and HNA-3b nucleic acids in a sample of a biological tissue intended for transplantation.
Type:
Grant
Filed:
April 3, 2015
Date of Patent:
May 8, 2018
Assignees:
ERNST-MORITZ-ARNDT-UNIVERSITÄT GREIFSWALD, DRK BLUTSPENDEDIENST WEST GMBH
Inventors:
Andreas Greinacher, Jan Wesche, Juergen Bux, Angelika Reil
Abstract: The invention relates to the discovery that HNA-3a and HNA-3b are antigens within a polypeptide sequence that is highly similar to the CTL2 amino acid sequence. This invention provides methods and kits for screening for HNA-3a and HNA-3b specific antibodies, HNA-3a and HNA-3b polypeptides and HNA-3a and HNA-3b nucleic acids in a sample of a biological tissue intended for transplantation.
Type:
Grant
Filed:
March 18, 2013
Date of Patent:
April 7, 2015
Assignees:
Ernst-Moritz-Arndt-Universität Greifswald, DRK Blutspendedienst West GmbH
Inventors:
Andreas Greinacher, Jan Wesche, Juergen Bux, Angelika Reil
Abstract: The invention relates to the discovery that HNA-3a and HNA-3b are antigens within a polypeptide sequence that is highly similar to the CTL2 amino acid sequence.
Type:
Application
Filed:
March 18, 2013
Publication date:
July 25, 2013
Applicants:
DRK BLUTSPENDEDIENST WEST GMBH, ERNST-MORITZ-ARNDT-UNIVERSITAT GREIFSWALD
Inventors:
Andreas Greinacher, Jan Wesche, Juergen Bux, Angelika Reil
Abstract: The invention relates to the discovery that HNA-3a and HNA-3b are antigens within a polypeptide sequence that is highly similar to the CTL2 amino acid sequence. This invention provides methods and kits for screening for HNA-3a and HNA-3b specific antibodies, HNA-3a and HNA-3b polypeptides and HNA-3a and HNA-3b nucleic acids in a sample of a biological tissue intended for transplantation.
Type:
Grant
Filed:
November 29, 2011
Date of Patent:
May 7, 2013
Assignees:
Ernst-Moritz-Arndt-Universität Greifswald, DRK Blutspendedienst West GmbH
Inventors:
Andreas Greinacher, Jan Wesche, Juergen Bux, Angelika Reil
Abstract: The invention relates to the discovery that HNA-3a and HNA-3b are antigens within a polypeptide sequence that is highly similar to the CTL2 amino acid sequence. This invention provides methods and kits for screening for HNA-3a and HNA-3b specific antibodies, HNA-3a and HNA-3b polypeptides and HNA-3a and HNA-3b nucleic acids in a sample of a biological tissue intended for transplantation.
Type:
Grant
Filed:
September 3, 2009
Date of Patent:
December 27, 2011
Assignees:
Ernst-Moritz-Arndt-Universität Greifswald, DRK Blutspendedienst West GmbH
Inventors:
Andreas Greinacher, Jan Wesche, Juergen Bux, Angelika Reil
Abstract: The invention relates to the discovery that HNA-3a and HNA-3b are antigens within a polypeptide sequence that is highly similar to the CTL2 amino acid sequence.
Type:
Application
Filed:
September 3, 2009
Publication date:
March 4, 2010
Applicants:
ERNST-MORITZ-ARNDT-UNIVERSITAT GREIFSWALD, DRK BLUTSPENDEDIENST WEST GMBH
Inventors:
Andreas Greinacher, Jan Wesche, Juergen Bux, Angelika Reil