Abstract: There is provided a topical formulation comprising a nucleophile, such as amino acids and most polypetides and/or a derivative thereof, for use in the treatment or prevention of itchy dry skin caused by urea, such as in uremic pruritus, of a subject. The amino acid may be histidine and the derivative may be a histidine degradation product, a peptide of histidine, a peptide of histidine and one or more additional amino acids, and a pharmaceutically-acceptable salt of histidine.
Type:
Application
Filed:
September 18, 2020
Publication date:
January 7, 2021
Applicant:
DRUG DELIVERY SOLUTIONS APS
Inventors:
Torkil MENNE, Johan SELMER, Jesper LANGE, Michelle GEORGIOU, Derek WHEELER, David EVANS
Abstract: There is provided a topical formulation comprising a nucleophile, such as amino acids and most polypeptides and/or a derivative thereof, for use in the treatment or prevention of itchy dry skin caused by urea, such as in uremic pruritus, of a subject. The amino acid may be histidine and the derivative may be a histidine degradation product, a peptide of histidine, a peptide of histidine and one or more additional amino acids, and a pharmaceutically-acceptable salt of histidine.
Type:
Grant
Filed:
June 16, 2017
Date of Patent:
October 20, 2020
Assignee:
DRUG DELIVERY SOLUTIONS APS
Inventors:
Torkil Menne, Johan Selmer, Jesper Lange, Michelle Georgiou, Derek Wheeler, David Evans