Patents Assigned to Drug Process Licensing Assoc., LLC
  • Manufacturing process for tiotropium bromide
    Patent number: 8680297
    Abstract: The present invention relates to a novel manufacturing process of pharmaceutically active compound of formula I used as a long-acting anticholinergic bronchodilator. Starting from oxalic acid derivative of formula III the invention describes preparation of a novel cyclic anhydride of formula II which is very efficient precursor in the synthesis of Tiotropium bromide (compound of formula I).
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: March 25, 2014
    Assignee: Drug Process Licensing Assoc., LLC
    Inventor: Milan Soukup