Patents Assigned to Drug Science Foundation
  • Aminoalkoxy or carboxyalkoxy derivatives of propranolol for immunoassay applications
    Patent number: 4795715
    Abstract: Derivatives of propranolol which have the following structure: ##STR1## where R is X--(CH.sub.2).sub.n --O, X is NH.sub.2 or COOH, n is 1,2,3,4, or 5, provided that when n is 1, X must be COOH, and R is attached in the 4',5',6',7' or 8' position. The compounds are useful in immunoassay applications to (1) conjugate to a protein carrier in order to prepare antibodies to propranolol and (2) to conjugate to a tracer moiety such as a radiolabeled ligand, an enzyme, an enzyme substrate or a fluorescent dye.
    Type: Grant
    Filed: October 3, 1986
    Date of Patent: January 3, 1989
    Assignee: Drug Science Foundation
    Inventors: Thomas D. Eller, Daniel R. Knapp
  • Aromatic derivatives of 13-azaprostanoic acid
    Patent number: 4695647
    Abstract: Novel substituted phenyl eicosanoid analogs having the formula: ##STR1## and their pharmaceutically acceptable esters and salts, wherein: R is H or OH;R.sub.1 is H or lower alkyl;X is --CH.sub.2 --CH.sub.2 -- or cis --CH.dbd.CH--;Y is --CH.sub.2 --, ##STR2## --O-- or --S--; n is 0 or 1; and.circle.A is (1) an eicosanoid nucleus (ring system), (2) a carbocyclic analog of an eicosanoid nucleus or (3) a heterocyclic analog of an eicosanoid nucleus wherein one of the carbons in a carbocyclic analog is replaced by O, S or N.
    Type: Grant
    Filed: March 22, 1984
    Date of Patent: September 22, 1987
    Assignee: Drug Science Foundation
    Inventors: Thomas D. Eller, Perry V. Halushka, Daniel R. Knapp, Dale Mais
  • Aminoalkoxy derivatives of propranolol for immunoassay applications
    Patent number: 4652681
    Abstract: Derivatives of propranolol which have the following structure: ##STR1## where R is X--(CH.sub.2).sub.n --O, X is NH.sub.2 or COOH, n is 1,2,3,4, or 5, provided that when n is 1, X must be COOH, and R is attached in the 4', 5', 6', 7' or 8' position. The compounds are useful in immunoassay applications to (1) conjugate to a protein carrier in order to prepare antibodies to propranolol and (2) to conjugate to a tracer moiety such as a radiolabeled ligand, an enzyme, an enzyme substrate or a fluorescent dye.
    Type: Grant
    Filed: April 15, 1982
    Date of Patent: March 24, 1987
    Assignee: Drug Science Foundation
    Inventors: Thomas D. Eller, Daniel R. Knapp
  • 1-((1-Methylethyl)amino)-3-(((4-alkylthio)1-naphthalenyl)oxy)-2-propanol
    Patent number: 4351848
    Abstract: Alkylthiopropranolol, compositions, and methods of use in the treatment of cardio-vascular disorders in mammals.
    Type: Grant
    Filed: March 16, 1978
    Date of Patent: September 28, 1982
    Assignee: Drug Science Foundation
    Inventor: Thomas Walle