Patents Assigned to DSM IP ASSETS
  • Patent number: 12290083
    Abstract: The present invention is directed to a composition comprising rapeseed protein, a hydrocolloid, and a vegetable oil, and to the use of such composition in food products such as a beverage.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: May 6, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Ya-Hui Chien, Arjen Sein, Johanna Corline Margriet Vink
  • Patent number: 12285033
    Abstract: A recombinant host capable of producing a steviol glycoside which overexpresses a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto. A recombinant host capable of producing a steviol glycoside which has been modified, preferably in its genome, to result in a deficiency in the production of a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto.
    Type: Grant
    Filed: January 31, 2024
    Date of Patent: April 29, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Viktor Marius Boer, Priscilla Zwartjens, Eric Van Den Berg
  • Patent number: 12275755
    Abstract: The present invention is directed to a process for purifying natamycin, to an all-trans polyene amphoteric macrolide, to a composition comprising said polyene amphoteric macrolide and to a process for preparing said polyene amphoteric macrolide.
    Type: Grant
    Filed: February 6, 2023
    Date of Patent: April 15, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Alexander Lucia Leonardus Duchateau, Peter Philip Lankhorst, Willebrordus Bernardus Van Scheppingen
  • Patent number: 12270006
    Abstract: The disclosure relates to a coating composition comprising a polymerizable compound of formula [1], wherein G is a residue of a hydrophobic hydroxy-functional oligomer, n is 1-10, each R1 independently is a residue of a C6-C20 aliphatic, cycloaliphatic, or aromatic hydrocarbon compound, and Z is a moiety having a polymerizable group; Formula [1] a hydrophilic polymer; a photo-initiator; optionally one or more further components, and a solvent. The polymerizable compound of formula [1] is typically present in an amount of 2.0-30 mass % based on total dry mass of the composition. Such coating composition can be made into a well-adhering single-layer hydrophilic coating on a surface of polymer substrates without providing a primer layer or chemically modifying the surface of the substrate. Upon wetting, the coating shows excellent lubricity and durability.
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: April 8, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventor: Johannes Wilhelmus Belt
  • Patent number: 12270065
    Abstract: The present invention is related to the production of bio-based carotenoids, particularly to methods for enhancing the titer and purity of beta-carotene fermentation in a suitable host cell.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: April 8, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: John Royer, Emily Davis Streaker, Warren Nelson Itterly
  • Patent number: 12258311
    Abstract: The present invention relates to a new compound and the dehydrogenation of that compound to produce retinal.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: March 25, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Marc-André Mueller, Bettina Wuestenberg, Viktor Zimmermann
  • Patent number: 12252724
    Abstract: The present invention is related to a novel enzymatic process for production of retinoids via a multi-step process, which process includes the use of heterologous enzymes having activity in a carotene-producing host cell, particularly wherein such process results in high percentage of retinoids, in trans-isoform.
    Type: Grant
    Filed: January 30, 2023
    Date of Patent: March 18, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Nathalie Balch, Paul Blomquist, Reed Doten, Peter Houston, Ethan Lam, Jenna McMahon, Joshua Trueheart, Celine Viarouge
  • Patent number: 12252614
    Abstract: Disclosed are compositions that may be useful for forming synthetic membranes, methods of forming membranes therefrom, and membranes. In an embodiment, a membrane comprises a free hydrophilic polymer comprising a polyoxazoline, and a polyurethane, the polyurethane comprising a backbone comprising the reaction product of a diisocyanate, a polymeric aliphatic 5 diol, and optionally a chain extender.
    Type: Grant
    Filed: March 29, 2023
    Date of Patent: March 18, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Jennifer Al-Rashid, Jacob Riffey, Chad Sugiyama, John Zupancich
  • Patent number: 12251391
    Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to prevent or treat dysfunctions in a gastrointestinal barrier. The present disclosure further relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to prevent or treat infections.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: March 18, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Britta Blokker, Stephane Duval, John Michael Geremia, Estefania Perez Calvo, Nathalie Richard, Jerome Schmeisser, Nicole Seifert, Viviane Verlhac
  • Patent number: 12252685
    Abstract: A feed control system and related methods for a heterologous product, such as a human milk oligosaccharide, fermentation system are disclosed. The feed control system comprises a feed controller. The feed controller comprises a processor and an interface. The processor is configured to obtain a biomass content in a fermentation broth. The processor is configured to determine a carbon input parameter based on the biomass content. The processor is configured to control a carbon input to the fermentation broth according to the carbon input parameter.
    Type: Grant
    Filed: November 10, 2022
    Date of Patent: March 18, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Natalia Chrapkova, Peter Becker, Ted Johanson, Mikael Jansen
  • Patent number: 12239762
    Abstract: The invention provides composite materials that form a biocompatible and bioresorbable settable ceramic-forming composition, and that possesses high strength when set and other desirable mechanical properties. The composite materials may include additive materials that provide beneficial advantages in the handling and physical properties of the material. When a hydrated precursor, the composite material is capable of being injected through cannulas for placement in treatment sites. The composite material provided desirable handling properties and sets in a clinically relevant time period.
    Type: Grant
    Filed: June 21, 2022
    Date of Patent: March 4, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Andrew Fallis, Steven Leonhardt, Justin Kontra, Rakesh Batish, Timothy Ringeisen
  • Patent number: 12227772
    Abstract: The present invention is related to modified sterol acyltransferase enzymes with improved activity and/or specificity towards acylation of the vitamin D3 precursor 7-dehydrocholesterol (7-DHC) to be used in biotechnological production of vitamin D3. The invention further relates to a yeast strain expressing said modified enzymes and their use in a process for production of vitamin D3 or derivatives and/or metabolites thereof.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: February 18, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Christopher Mark Farrell, Lisa Ann Laprade, Otto Martin Lehmann, Joshua Trueheart
  • Patent number: 12220477
    Abstract: The present invention relates to cosmetic compositions which comprise a hyperbranched copolymer of the monomers dodecenyl succinic acid anhydride, diisopropanol amine and bis-dimethylaminopropyl amine having quaternary terminal groups and a liquid and/or solid organic UV-filter. The copolymer is used in a cosmetic composition comprising the UV-filter for reducing the material transfer to a contacted surface. Preferably the copolymer is polyquatemium-110.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: February 11, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventor: Christine Mendrok-Edinger
  • Patent number: 12214041
    Abstract: In an embodiment, a polyurethane comprises the residues of i. an aliphatic diisocyanate, ii. an aliphatic diol comprising a poly(ethylene oxide) moiety, iii. an aliphatic diol comprising a polycarbonate moiety, and iv. a chain extender, wherein the polyurethane has a melting temperature of 140° C. or less and has a weight average molecular weight of from 100,000 to 500,000 g/mol. In an embodiment, the polyurethane is substantially devoid of catalyst. In an embodiment, the polyurethane is formed by reactive extrusion. In an embodiment, a medical device comprises the polyurethane and a bioactive agent. The medical devices, methods, and polyurethanes may exhibit benefits in end-product biostability, drug release profile, health and safety, and processing speed or reproducibility.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: February 4, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Jennifer Al-Rashid, Jacob Riffey, John Andrew Zupancich
  • Patent number: 12213498
    Abstract: The present invention relates to improved formulations of propandiol mononitrate and derivatives thereof as well as to the production of such formulations.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: February 4, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Dominik Josef Brunner, Laure Clasadonte, Martin Reto Gadient, Roland Schuepfer
  • Patent number: 12202853
    Abstract: The present invention is directed to a process for purifying natamycin, to an epoxide polyene amphoteric macrolide, to a composition comprising said polyene amphoteric macrolide and to a process for preparing said polyene amphoteric macrolide.
    Type: Grant
    Filed: January 19, 2023
    Date of Patent: January 21, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Alexander Lucia Leonardus Duchateau, Peter Philip Lankhorst, Willebrordus Bernardus Van Scheppingen
  • Patent number: 12203048
    Abstract: The present invention describes a vegetable oil comprising a polyunsatured fatty acid having at least 20 carbon atoms (LC-PUFA), which oil has (a) an anisidine value (AnV) of less than 25; (b) a peroxide value (POV) of less than 10; (c) a triglyceride content of greater than 90%; and/or (d) an Oil Stability Index (OSI) of greater than 5 hours at 80° C.
    Type: Grant
    Filed: February 9, 2021
    Date of Patent: January 21, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Daniel Verkoeijen, Kristian Zuur, Hendrik Louis Bijl
  • Patent number: 12193456
    Abstract: The present invention relates to a method of reducing methane emissions in ruminants, said method encompassing treating pre-/young ruminants with 3-nitrooxypropanol.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: January 14, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Stephane Duval, Maik Kindermann, Sarah Jade Meale, Diego Pablo Morgavi
  • Patent number: 12195769
    Abstract: The present invention relates to a variant polypeptide having a lipase activity, wherein the polypeptide may be a polypeptide that has an amino acid sequence which has at least 70% identity to a mature amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 6, wherein the polypeptide comprises an amino acid substitution at position 295 and at least one further amino acid substitution at position 113, 121, 179 and/or 284, wherein the positions are defined with reference to SEQ ID NO: 1 or SEQ ID NO: 6. The invention further relates to a process for preparing a dough wherein a polypeptide as disclosed herein is used and baked product prepared from the dough.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: January 14, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Joke Anneleen Putseys, Neil Carr, René Marcel De Jong, Aloysius Wilhelmus Rudolphus Hubertus Teunissen
  • Patent number: 12171905
    Abstract: Disclosed herein is a medical implant component comprising a composite biotextile, which biotextile comprises i) a polyolefin fibrous construct comprising at least one strand with titer of 2-250 dtex, tensile strength of at least 10 cN/dtex and comprising high molar mass polyolefin fibers and ii) a coating comprising a biocompatible and biostable polyurethane elastomer comprising a polysiloxane segment and/or having one or more hydrophobic endgroups, wherein the polyurethane coating is present on at least part of the surface of the biotextile and in an amount of 2.5-90 mass % based on composite biotextile. Such composite biotextile, like a partly coated woven fabric, shows an advantageous combination of good biocompatibility, especially hemocompatibility, high strength and pliability, and laser cuttability; allowing to make pieces of fabric having well-defined regular edges that have high suture retention strength. The invention also provides a method of making said composite biotextile.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: December 24, 2024
    Assignee: DSM IP ASSETS B.V.
    Inventors: Nicolaes Hubertus Maria De Bont, Noel L. Davison, Mandy Maria Jozefina Wiermans