Patents Assigned to DSM IP Assets B.V.
  • Patent number: 12286658
    Abstract: This invention relates to a method of producing one or more human milk oligosaccharides (HMOs), in particular LNT and/or LNnT, in a genetically engineered cell comprising an enhanced oligosaccharide transport capability. The genetically modified cell comprises a series of genetic modification which enable the production of one or more HMO(s), and a series of genetic modification that enhances the transport of lactose and produced HMO(s).
    Type: Grant
    Filed: May 17, 2022
    Date of Patent: April 29, 2025
    Assignee: DSM IP Assets B.V.
    Inventor: Manos Papadakis
  • Publication number: 20250129395
    Abstract: The present disclosure provides a method for increasing production of a polyunsaturated fatty acid, especially eicosapentaenoic acid (EPA), in a microorganism, comprising adjusting the macro-and/or micronutrients during fermentation. The invention includes any culture, biomass, and oil produced by the method.
    Type: Application
    Filed: January 24, 2023
    Publication date: April 24, 2025
    Applicant: DSM IP Assets B.V.
    Inventors: Jose R. GARCIA, Adam BURJA, Xiao Daniel DONG
  • Publication number: 20250069708
    Abstract: A computer-based method for determining a sunscreen composition comprising a plurality of UV filter substances, comprises the steps of selecting at least one constraint for at least one characteristic of the composition to be determined (step 30), the at least one constraint comprising a sunscreen performance target; selecting an optimization objective from a plurality of optimization objectives (step 50); and automatically determining the sunscreen composition as a composition of filter substances from a set of filter substances (step 100), the composition meeting the at least one constraint and being optimized with respect to the selected optimization objective. The automatic determination comprises the steps of generating a plurality of candidate compositions, determining a sunscreen performance of the candidate compositions using a performance simulation tool and comparing the determined sunscreen performance of the candidate compositions with the sunscreen performance target.
    Type: Application
    Filed: November 7, 2024
    Publication date: February 27, 2025
    Applicant: DSM IP Assets B.V.
    Inventor: Alexander SCHLIFKE
  • Patent number: 12203075
    Abstract: The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in the production of PUFAs, including PUFAs enriched in docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), or a combination thereof. The present invention is directed to vectors and host cells comprising the nucleic acid molecules, polypeptides encoded by the nucleic acid molecules, compositions comprising the nucleic acid molecules or polypeptides, and methods of making and uses thereof.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: January 21, 2025
    Assignee: DSM IP Assets B.V.
    Inventors: Kirk E. Apt, Leslie Richter, David Simpson, Ross Zirkle
  • Patent number: 12188056
    Abstract: The present disclosure relates to the production of sialylated Human Milk Oligosaccharides (HMOs), in particular to the biosynthetic production of 3?-sialyllactose (3?SL), and to genetically engineered cells and methods suitable for said production.
    Type: Grant
    Filed: March 1, 2023
    Date of Patent: January 7, 2025
    Assignee: DSM IP Assets B.V.
    Inventor: Manos Papadakis
  • Publication number: 20240409841
    Abstract: Disclosed herein are processes for obtaining a microbial oil comprising one or more polyunsaturated fatty acids (PUFAs) from one or more microbial cells by lysing the cells to form a lysed cell composition, treating the lysed cell composition to form an oil-containing emulsion and then recovering the oil from the oil-containing emulsion. Further disclosed herein is microbial oil comprising one or more PUFAs that is recovered from microbial cells by at least one process described herein.
    Type: Application
    Filed: August 20, 2024
    Publication date: December 12, 2024
    Applicant: DSM IP Assets B.V.
    Inventors: Neil Francis LEININGER, Ginger Marie SHANK, Xiao Daniel DONG, Joseph William PFEIFER, III, Vidya PAI
  • Patent number: 12152261
    Abstract: The present invention relates to a method for reducing fructan in a fructan-containing food product, including adding an invertase belonging to enzyme classification EC 3.2.1.26 to the food product, and incubating the food product with the invertase, wherein fructan in the fructan-containing food product is hydrolysed. The invention further relates to the use of an invertase belonging to enzyme classification EC. 3.2.1.26 for the preparation of a medicament or a dietary supplement for the treatment of a person suffering from irritable bowel syndrome. Invertase (EC 3.2.1.26) may optionally by further combined with inulinase (EC3.2.1.7) and/or beta-fructosidase (EC 3.2.1.80).
    Type: Grant
    Filed: February 18, 2020
    Date of Patent: November 26, 2024
    Assignee: DSM IP Assets B.V.
    Inventor: Petrus Jacobus Theodorus Dekker
  • Patent number: 12133542
    Abstract: The present invention relates to animal feed compositions comprising at least one probiotic and polypeptides having muramidase activity.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: November 5, 2024
    Assignees: Novozymes A/S, DSM IP Assets B.V.
    Inventors: Rual Lopez-Ulibarri, Estefania Perez Calvo, Wolfgang Schliffka
  • Patent number: 12104139
    Abstract: Disclosed herein are processes for obtaining a microbial oil comprising one or more polyunsaturated fatty acids (PUFAs) from one or more microbial cells by lysing the cells to form a lysed cell composition, treating the lysed cell composition to form an oil-containing emulsion and then recovering the oil from the oil-containing emulsion. Further disclosed herein is microbial oil comprising one or more PUFAs that is recovered from microbial cells by at least one process described herein.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: October 1, 2024
    Assignee: DSM IP Assets B.V.
    Inventors: Neil Francis Leininger, Ginger Shank, Xiao Dong, Joseph William Pfeifer, III, Vidya Pai
  • Patent number: 12102103
    Abstract: The presence of either a calcium source or a carbonate source with GH30 xylanses significantly improves the release of xylan oligomers from maize and other feeds compared to the same xylanases without the calcium or carbonate source. Animal feed and animal feed additives comprising a combination of one or more polypeptides having xylanase activity; and one or more sources of calcium; and/or one or more sources of carbonate, wherein the polypeptide is a GH30 xylanase provide for improved xylan release from feedstuff.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: October 1, 2024
    Assignees: Novozymes A/S, DSM IP Assets B.V.
    Inventor: Eduardo Antonio Della Pia
  • Patent number: 12076463
    Abstract: The disclosure relates to methods of making an osteoconductive polymer article for use as an orthopedic implant comprises steps of forming an article from a biocompatible, non-biodegradable polymer, the article comprising a non-flat surface with roughness Ra of at least 5 ?m; providing a dispersion of bioactive ceramic particles of particle size at most 10 ?m in a first solvent comprising a solvent for the polymer; coating at least the non-flat surface with the dispersion in at least one step; and rinsing the coated article with a second solvent being a non-solvent for the polymer to substantially remove the first solvent.
    Type: Grant
    Filed: June 27, 2022
    Date of Patent: September 3, 2024
    Assignee: DSM IP Assets B.V.
    Inventors: Jens Christoph Thies, Ruud Jozef Regina Wilhelmus Peters, Pieter J. Emans, Jacob Koenen
  • Patent number: 12049658
    Abstract: The present invention is related to production of retinyl esters, such as in particular retinyl acetate, an important building block for production of vitamin A. The retinyl esters might be generated via enzymatic conversion of retinol which process includes the use of enzymes with acetyl-transferase (ATF) activity, thus acetylating retinol into retinol/retinyl acetate. Said process is particularly useful for biotechnological production of vitamin A.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: July 30, 2024
    Assignee: DSM IP Assets B.V.
    Inventors: Nathalie Balch, Paul Blomquist, Reed Doten, Peter Houston, Ethan Lam, Jenna Mcmahon, Joshua Trueheart, Celine Viarouge, René Marcel De Jong
  • Patent number: 12049617
    Abstract: The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified yeast strains expressing enzymes having improved C-8 sterol isomerase activity leading to increased ratios of 7-DHC in the sterol mix.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: July 30, 2024
    Assignee: DSM IP Assets B.V.
    Inventors: Christopher Mark Farrell, Lisa Ann Laprade, Otto Martin Lehmann, Joshua Trueheart, Bastien Jean Wolfgang Chevreux
  • Patent number: 12018309
    Abstract: The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified host strains expressing enzymes having improved C-5 sterol 5 desaturase activity and their use in a process for production of vitamin D3 or derivatives and/or metabolites thereof.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: June 25, 2024
    Assignee: DSM IP Assets B.V.
    Inventors: Christopher Mark Farrell, Lisa Ann Laprade, Otto Martin Lehmann, Joshua Trueheart, Bastien Jean Wolfgang Chevreux
  • Publication number: 20240188590
    Abstract: An animal feed comprising an animal feed additive, said additive comprising co-granules, each co-granule comprising at least two classes of enzymes, said co-granules comprising a core unit and a protective coating such that the dose of each of the enzymes in the feed is set in each granule rather than by the level of homogeneity of single-enzyme granules or by the efficiency of the mixing.
    Type: Application
    Filed: December 8, 2022
    Publication date: June 13, 2024
    Applicants: Novozymes A/S, DSM IP Assets B.V.
    Inventors: Flemming Borup, Ivan De Jesus Gaytan Perez
  • Patent number: 12006504
    Abstract: The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: June 11, 2024
    Assignees: DSM IP Assets B.V., DOW AgroSciences LLC
    Inventors: Terence A. Walsh, Daniel Gachotte, Ann Owens Merlo, Paul G. Roessler, James George Metz, Scott Bevan, Jerry M. Kuner
  • Patent number: 11987819
    Abstract: The subject disclosure features, in one aspect, a method for producing lipids enriched for EPA, comprising modifying a microalga to increase expression of PFA1, and/or PFA3, and culturing the modified microalga under conditions which allow the expression of PFA1, and/or PFA3, wherein lipids enriched for EPA are produced. Also featured is a recombinant microalga in which PFA1, and/or PFA3, is overexpressed. Such recombinant microalgae have been demonstrated herein to produce very favorable fatty acid lipid profiles (e.g., increased levels of EPA, increased ratio of EPA:DHA, decreased levels of DPA n-6, etc.).
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: May 21, 2024
    Assignee: DSM IP Assets B.V.
    Inventors: Anne-Cecile V. Bayne, Ross E. Zirkle
  • Patent number: 11976253
    Abstract: The current invention relates to a method of separating lipids from a lipids containing biomass by demulsification under mild conditions, to an oil and to a delipidated biomass as obtained by such a method.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: May 7, 2024
    Assignees: Evonik Operations GmbH, DSM IP Assets B.V.
    Inventors: Annika Heining, Martin Heining
  • Patent number: 11946017
    Abstract: The current invention relates to a method of separating polyunsaturated fatty acids containing lipids from a lipids containing biomass.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: April 2, 2024
    Assignees: Evonik Operations GmbH, DSM IP Assets B.V.
    Inventors: Manfred Bärz, Marc Beiser, Georg Borchers, Stephen Robert Cherinko, Mathias Dernedde, Michael Diehl, Xiao Daniel Dong, Jürgen Haberland, Michael Benjamin Johnson, Robert Cody Kertis, Jochen Lebert, Neil Francis Leininger, Kirt Lyvell Matthews, Sr., Holger Pfeifer, Christian Rabe, Shannon Elizabeth Ethier Resop, Ginger Marie Shank, Vinod Tarwade, David Allen Tinsley, Daniel Verkoeijen
  • Patent number: 11925193
    Abstract: A recombinant host capable of producing a steviol glycoside which overexpresses a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto. A recombinant host capable of producing a steviol glycoside which has been modified, preferably in its genome, to result in a deficiency in the production of a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: March 12, 2024
    Assignee: DSM IP Assets B.V.
    Inventors: Viktor Marius Boer, Priscilla Zwartjens, Eric Van Den Berg