Patents Assigned to DSM N.V.
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Publication number: 20120121772Abstract: A process for preparing an oil mixture of an T6 PUFA (such as ARA) with T3 PUFA (such as DHA and/or EPA) is described which can he included into edible formulations such as foodstuffs, and in particular infant formulas. A crude T6 PUFA (e.g. ARA)-containing oil is admixed with a crude T3 PUFA (e.g. DHA or EPA)-containing oil to produce a crude oil mixture (or blend). This mixture is then purified before addition to a foodstuff Alternatively, a crude T6 PUFA-containing oil is treated, and a crude T3 PUFA-containing oil is also treated, and the two purified oils are then blended prior to deodorising and then added to a foodstuff. The purifying includes acid and/or alkali treatment, bleaching, deodorization, filtering, polishing or cooling. The purifying removes trace metals, pigments, carbohydrates, proteins, sulphur, sterols, mono- or di-glycerides from the oils which renders them suitable for human consumption.Type: ApplicationFiled: November 14, 2011Publication date: May 17, 2012Applicant: DSM N.V.Inventors: Hendrik Louis BIJL, Johannes Hendrik WOLF
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Publication number: 20090105342Abstract: Edible formulations, such as polyunsaturated fatty acids (PUFAs) such as pharmaceutical compositions or nutritional supplements, are disclosed comprising arachidonic acid (ARA). They are adapted to deliver from 150 mg to 1 g per day of ARA and may contain other PUFAs, for example docosahexaenoic acid (DHA). The DHA dosage is from 400 to 600 mg per day, and the ratio of ARA:DHA may be from 1:5 to 5:1. Pharmaceutical compositions comprising ARA and DHA at a ratio of ARA:DHA of 1:1 to 1:2 are also disclosed, as are foodstuffs comprising 0.1 to 5% ARA. Such formulations can be used to increase ARA levels in vivo, for example in pregnant women or for people who have diseases or conditions associated with low ARA levels.Type: ApplicationFiled: December 18, 2008Publication date: April 23, 2009Applicant: DSM N.V.Inventors: Isabel Antonia Maria VAN WATERSCHOOT, Hugo Streekstra
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Publication number: 20080009006Abstract: Methods are provided for isolation of DNA sequences encoding proteins with properties of interest by means of expression cloning in filamentous fungal host cells. The isolated DNA sequences are useful in processes for producing the proteins of interest.Type: ApplicationFiled: February 20, 2007Publication date: January 10, 2008Applicant: DSM N.V.Inventors: Johannes Maarten Van Den Brink, Gerardus Cornelis Maria Selten, Johannes Petrus Theodorus Wilhelmus Van Den Hombergh
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Publication number: 20070203321Abstract: The present invention relates to a method of improving the tensile, elongation, and/or modulus (overall toughness) of a radiation curable composition by reacting in a free multi-functional isocyanate prior to curing.Type: ApplicationFiled: April 23, 2007Publication date: August 30, 2007Applicant: DSM N.V.Inventors: Wendell Cattron, Xiaosong Wu
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Patent number: 7122253Abstract: A curable resin composition comprising (A) reactive particles prepared by bonding (A1) at least one of oxide particles of an element selected from the group consisting of silicon, aluminum, zirconium, titanium, zinc, germanium, indium, tin, antimony, ruthenium, rhenium, silver, nickel, cupper and cerium, and (A2) an organic compound which comprises a polymerizable unsaturated group, (B) a compound having two or more polymerizable unsaturated groups in the molecule, and optionally (C) a terminal reactive polysiloxane compound having at least one polymerizable group, other than organic compound (A2).Type: GrantFiled: April 17, 2001Date of Patent: October 17, 2006Assignee: DSM N.V.Inventors: Yoshikazu Yamaguchi, Isao Nishiwaki, Yuichi Eriyama, Takashi Ukachi, Takao Yashiro, Michiko Takahashi
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Patent number: 7109253Abstract: A metal conductor is provided with a cured coating of about 2.5 ?m to about 500 ?m thickness, which cured coating has a dielectric dissipation factor (60 Hz, 24° C.) of lower than about 0.05 and is a radiation-cured coating formulated from components comprising: a) an acrylate functional urethane oligomer having a hydrocarbon backbone; b) one or more mono- or polyfunctional diluents; and optionally, c) one or more light sensitive radical generating compounds. The invention further provides a radiation-curable coating composition for coating a metal conductor. Also disclosed is a method of making a metal conductor provided with a cured coating of about 2.5 ?m to about 500 ?m thickness, which cured coating has a dielectric dissipation factor (60 Hz, 24° C.) of lower than about 0.05.Type: GrantFiled: October 30, 1997Date of Patent: September 19, 2006Assignee: DSM N.V.Inventors: Vadim V. Krongauz, Stephen C. Lapin, Anthony J. Tortorello
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Patent number: 7045160Abstract: The preparation of a proteinaceous substance suitable for use in a foodstuff is described which comprises fungal fells of the order Mucorales. The cells are grown in a fermentor vessel in a liquid which is mixed during fermentation, after which the RNA content of the fungal cells is reduced to below 4% the fungal cells processed into an edible substance. This substance is then mechanically texturized into edible textured product for inclusion into foodstuffs, for example in the form of chunks as a meat substitute.Type: GrantFiled: September 15, 1999Date of Patent: May 16, 2006Assignee: DSM N.V.Inventors: André de Haan, Sigbertus Godefridus Maria Geraats, Fredericus Johannes Kruyssen, Hendrik Louis Bijl
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Publication number: 20060093779Abstract: Optical disc adhesives and lacquers comprising components that undergo free-radical polymerization when exposed to radiation and a cure-enhancing amount of R—SH, wherein R is a heterocycle; cationic, free-radical, and hybrid adhesives for digital versatile discs (DVD) comprising components that undergo cationic and/or free-radical polymerization when exposed to radiation and a corrosion-inhibiting amount of R—SH, R1-R2 and/or an acyclic thiol, wherein R is a heterocycle, R1 is a substituted or unsubstituted phenyl as a substituent of R2 or forming with R2 a bicyclic structure, and R2 is a heterocycle comprising at least one double bond and at least two N atoms; and optical media, e.g., CD-DA, CD-ROM, CD-R, DVD, and the like, that include one, or a combination, of the foregoing inventive adhesive or lacquer compositions.Type: ApplicationFiled: December 14, 2005Publication date: May 4, 2006Applicant: DSM N.V.Inventors: Chander Chawla, Michael Sullivan, Vadim Krongauz, Christopher Tronche
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Publication number: 20060076534Abstract: Inner and outer primary and matrix material compositions which, after curing, exhibit a high degree of uniformity after curing even when the coating is applied onto optical fibers at relatively high shear rates, e.g., such as those experienced at high optical fiber coating line speeds. These compositions are provided in significant part by the selective incorporation of at least one radiation-curable oligomer into the compositions. In particular, and with respect to inner primary coatings, the oligomer should be selected so that the value m of an uncured radiation-curable inner primary coating composition in the equation ? = K ? ? ? ? ? ? ? ? 1 + ( ? ? ? ? ? ) m ( I ) is advantageously equal to or greater than about 0.90.Type: ApplicationFiled: November 21, 2005Publication date: April 13, 2006Applicant: DSM N.V.Inventors: David Szum, Robert Johnson
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Patent number: 6979735Abstract: The present invention describes novel agglomerates in crystalline form of ?-lactam compounds. Furthermore, a process for the preparation of said agglomerates, wherein a solution or suspension of at least one ?-lactam compound in a solvent is mixed with one or more anti-solvents has been described.Type: GrantFiled: April 3, 2000Date of Patent: December 27, 2005Assignee: DSM N.V.Inventors: Johannes Booij, Ageeth Geertruida Lefferts
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Patent number: 6955909Abstract: The present invention discloses a selection marker free system which can be used to introduce genetic modifications to in bacteria, yeasts and fungi. The system can be employed to introduce or delete desired genes or DNA fragments in the genome of the indicated host species without leaving any undesired DNA i.e. the selection marker used for selection of transformants or other DNA used for cloning. In this way strains have been developed containing only desired genes introduced at desired chromosomal sites. Similarly, desired DNA fragments have been deleted or replaced at desired sites.Type: GrantFiled: February 26, 1999Date of Patent: October 18, 2005Assignee: DSM N.V.Inventors: Gerardus Cornelis Maria Selten, Bart Willem Swinkels, Robertus Franciscus Maria Van Gorcom
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Publication number: 20050161634Abstract: Inner and outer primary and matrix material compositions which, after curing, exhibit a high degree of uniformity after curing even when the coating is applied onto optical fibers at relatively high shear rates, e.g., such as those experienced at high optical fiber coating line speeds. These compositions are provided in significant part by the selective incorporation of at least one radiation-curable oligomer into the compositions. In particular, and with respect to inner primary coatings, the oligomer should be selected so that the value m of an uncured radiation-curable inner primary coating composition in the equation ? = K ? ? ? ?? 1 + ( ? ? ?? ) m ( I ) is advantageously equal to or greater than about 0.90.Type: ApplicationFiled: March 21, 2005Publication date: July 28, 2005Applicant: DSM N.V.Inventors: David Szum, Robert Johnson
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Publication number: 20050137402Abstract: Mono- and disubstituted aryl or heterocyclic acetylenes are produced by a process comprising reacting an aryl nitrile with an alkynylzinc compound, a bis-alkynylzinc compound, or an alkynylmagnesium compound, in the presence of a nickel/phosphine catalyst.Type: ApplicationFiled: December 17, 2003Publication date: June 23, 2005Applicant: DSM N.V.Inventors: Joseph Miller, Jonathan Penney
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Patent number: 6893679Abstract: The invention relates to a composite material and a process for manufacturing the composite material by applying at least a single organic barrier layer to a substrate to reduce the oxygen permeability of the substrate. Depending on the intended application, the composite material may also include an outer cover layer over the barrier layer to improve moisture resistance. The preferred materials are triazines, particularly melamine, that are vapor-deposited onto the substrate to form a thin, durable transparent barrier layer.Type: GrantFiled: January 14, 2003Date of Patent: May 17, 2005Assignee: DSM N.V.Inventors: Shahab Jahromi, Olav M Aagaard, Jan M Houben, Karel G. H. Raemaekers
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Patent number: 6858755Abstract: Process for the preparation of urea from ammonia and carbon dioxide, wherein the waste gases released at virtually atmospheric pressure in a urea plant are compressed by an ejector driven by the waste gas from the high-pressure synthesis and are supplied to a medium-pressure absorber. The pressure of the waste gases is increased by 0.15-1 MPa.Type: GrantFiled: November 23, 2001Date of Patent: February 22, 2005Assignee: DSM N.V.Inventors: Jozef Hubert Meessen, Kees Jonckers
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Patent number: 6852829Abstract: A process for the simultaneous preparation of polyamide-6 with at least two different viscosities comprising prepolymerisation of ?-caprolactam and/or other polyamide-6 precursors in the presence of water, wherein at least part of the necessary water is supplied to the prepolymerisation via the gas phase and the obtained prepolymer is progressively moved and treated with an inert gas in at least two condensation reaction zones or reactors, placed in series, and the prepolymerisation and condensation are carried out in reactor(s) or reaction zones having a self-renewing interface between molten phase and gas phase with a large surface/volume ratio of the molten phase and the molten phase is relatively strong mixed.Type: GrantFiled: April 17, 2001Date of Patent: February 8, 2005Assignee: DSM N.V.Inventor: Wim Buijs
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Patent number: 6846955Abstract: The invention relates to a process for racemising an enantiomer-enriched Schiff base of a primary amino acid amide with a strong base that is chemically reactive towards water. The reaction is conducted in an organic solvent. Preferably a metal alkoxide, a metal alkyl, a metal amide, or a metal hydride, in particular a metal alkoxide is applied as the strong base. As the Schiff base preferably N-benzylidene primary amino acid amide is used, with the primary amino acid amide preferably being derived from an aliphatic primary amino acid amide, for example tertiary-leucine amide. As organic solvent use is preferably made of an aromatic hydrocarbon, a cyclic, aliphatic hydrocarbon or a ether, in particular an aromatic hydrocarbon is applied. The invention may also be applied for the racemisation of an enantiomer-enriched primary amino acid amide.Type: GrantFiled: June 22, 2001Date of Patent: January 25, 2005Assignee: DSM N.V.Inventors: Robert Patrick Hof, Petrus Johannes Hermsen, Ronus de Bode
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Patent number: 6841691Abstract: Method for the preparation of an enantiomerically enriched ester, in which a mixture of the enantiomers of the corresponding secondary alcohol is subjected, in the presence of an acyl donor, to an enantioselective conversion in the presence of a racemisation catalyst upon which the ester is formed and an acyl donor residue is obtained, and in which the acyl donor residue is irreversibly removed from the phase in which the enantioselective conversion takes place. Preferably the enantioselective conversion is carried out enzymatically and a transfer hydrogenation catalyst is used as racemisation catalyst. The secondary alcohol can be formed in situ from the corresponding ketone, in the presence of a hydrogen donor. It is also possible to use a mixture of the secondary alcohol and the corresponding ketone as substrate. Preferably the acyl donor is chosen so that the acyl donor residue is converted in situ into another compound and/or the acyl donor residue is removed via distillation under reduced pressure.Type: GrantFiled: May 21, 2001Date of Patent: January 11, 2005Assignee: DSM N.V.Inventors: Gerardus Karel Maria Verzijl, Johannes Gerardus Vries De, Quirinus Bernardus Broxterman
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Publication number: 20040241647Abstract: Methods are provided for isolation of DNA sequences encoding proteins with properties of interest by means of expression cloning in filamentous fungal host cells. The isolated DNA sequences are useful in processes for producing the proteins of interest.Type: ApplicationFiled: April 4, 2002Publication date: December 2, 2004Applicant: DSM N.V.Inventors: Johannes Maarten Van Den Brink, Gerardus Cornelis Maria Selten, Johannes Petrus Theodorus Wilhelmus Van Den Hombergh
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Patent number: 6812001Abstract: A process for the isolation of crystalline carotenoid compound from microbial biomass comprising disrupting the microbial cell walls, separating cellular debris from the carotenoid-containing residue, washing one member of the group consisting of the microbial biomass, the disrupted cell mass and the carotenoid-containing reside with a solvent to remove lipid, suspending the obtained carotenoid crystals in water to float the crystals, recovering the crystals and, optionally, further purifying the crystals which avoids the use of large amounts of solvent of carotenoid extraction process.Type: GrantFiled: December 20, 2001Date of Patent: November 2, 2004Assignee: DSM N.V.Inventors: Mieke Sibeijn, Robertus Mattheus De Pater