Abstract: The invention relates to a method for carrying out recombination at a target locus in a Rasamsonia cell. The invention also relates to Rasamsonia cells, for example Rasamsonia cells produced by such a process. The invention further relates to processes in which such Rasamsonia cells are used and to the resulting enzyme compositions. The invention further relates to nucleic acid and amino acid sequences.

Abstract: The present invention relates to a composition comprising a tryptophan-containing peptide and having a Trp/LNAA ratio of more than 0.1 for decreasing eating or appetite during or after stress.

Abstract: A radiation curable aqueous coating composition having a 85° gloss of ?60 upon drying comprising (A) 10 to 99 wt % of a polyurethane, (B) 1 to 90 wt % of a radiation curable component; (C) 0.1 to 10 wt % of an associative thickener; wherein at least 80 wt % of (A)+(B)+(C) has a particle size greater than 500 nm and wherein the C?C bond concentration of the composition is 0.2 to 5.0 mmol per g of (A)+(B)+(C).

Abstract: The invention relates to a multilayered material sheet comprising a consolidated stack of unidirection monolayers of drawn ultra high molecular weight polyolefine. The draw direction of two subsequent monolayers in the stack differs. Moreover the thickness of at least one monolayer does not exceed 50 ?m, and the strength of at least one monolayer is comprised between 1.2 GPa and 3 GPa. The invention also relates to a ballistic resistant article comprising the multilayered material sheet and to a process for the preparation of the ballistic resistant article.

Abstract: The present invention relates to a process for producing a dicarboxylic acid comprising fermenting a fungal cell in a vessel comprising a suitable fermentation medium, comprising adding a gas flow which comprises 20 to 35 v/v % of oxygen and less than 0.1 v/v % of carbon dioxide to the fermentation medium, and maintaining an average partial carbon dioxide pressure of at least about 0.35 bar in the fermentation medium, and producing the dicarboxylic acid.

Abstract: This invention relates to the production of 7-dehydrocholesterol, 25-hydroxy-7-dehydrocholesterol, and 25-hydroxy ergosterol in yeast such as Saccharomyces cerevisiae. It also relates to various enzymes catalyzing the reduction of the double bond at position 24 of lanosterol, dimethyl zymosterol, methyl zymosterol, zymosterol, cholesta-7, 24-dienol, or cholesta-5,7,24-trienol; or the hydroxylation at position 25 of ergosterol, 7-dehydrocholesterol, cholesta-8-enol, and cholesta-7-enol. It also relates to various nucleic acids encoding cholesterol C25-hydroxylases and sterol ?24-reductases and their use to produce and hydroxylate 7-dehydrocholesterol or ergosterol. It also relates to the yeast strains so produced, and methods of making these sterols that include the steps of cultivaton a transformed yeast cell, and harvesting the resulting sterol(s).

Abstract: The invention relates to a flexible composite material. This material comprises at least 2 layers comprising high strength fibers, said at least 2 layers comprise consolidated elements and unconsolidated elements, the unconsolidated elements being in contact with the consolidated elements. The flexible composite material shows a better anti-ballistic performance compared to materials known so far.

Abstract: The present invention relates to new (foodgrade) solid lipid nanoparticles, as well as the production of such solid lipid nanoparticles and the use of them.

Abstract: The invention relates to an implantable valve prosthesis, optionally comprising a support structure and at least one valve leaflet. The valve prosthesis comprises a material structure of unidirectional reinforcing elements of drawn ultra high molecular weight polyolefin, extending in at least two directions, wherein the modulus of elasticity of the polyolefin reinforcing elements is at least 60 GPa. The invention furthermore relates to a method for manufacturing such an implantable valve. The valve is easily manufactured and has an improved durability.

Abstract: The invention relates to a novel use of a phospholipase A in the production of cake to improve at least one of the properties selected from the group consisting of: (i) batter viscosity, (ii) specific density, (iii) initial crumb softness, (iv) crumb pore homogeneity, (v) crumb pore diameter, (vi) crumb softness upon storage, (vii) shelf life and/or (viii) cake volume. The invention also relates to a novel use of phospholipase A in the production of cake to enable reduction of the amount of eggs and/or fat used in the recipe.

Abstract: The present invention describes natamycin comprising needle shaped crystals.

Abstract: The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimethylpentadecan-2-one in a multistep synthesis from a mixture of (5E,9E)-, (5E,9Z)-, (5Z,9E)- and (5Z.9Z)-isomers of 6,10,14-trimethylpentadeca-5,9,13-trien-2-one or 6,10,14-trimethylpentadeca-5,9-dien-2-one. The process is very advantageous in that it forms in an efficient way the desired chiral product from a mixture of stereoisomers of the starting product.

Abstract: A waterproof seal for electrical assemblies having conductive wires attached to a metal contact and inserted into a connector body. The conductive wires and metal contact are coated with solder to fill the gaps. The space between the soldered wires and the connector body are filled with an epoxy. The wire insulation and connector body are continuously sealed with a bonding agent. A section of wire insulation and the connector body are encased within an outer plastic jacket overmold.

Abstract: The present invention relates to new antimicrobial compositions and their use in the treatment of products such as food products.

Abstract: The invention is directed to microbial oils containing omega-3 polyunsaturated fatty acids comprising docosahexaenoic acid, eicosapentaenoic acid, and optionally docosapentaenoic acid and dosage forms containing such oils.

Abstract: A method of reducing the deterioration of a wetted hydrophilic coating caused by sterilization by radiation is provided. The method comprises the step of incorporating a thiosulfate anion and a buffer into the wetting hydrophilic coating comprising water. Some embodiments of the invention relate to a wetted hydrophilic coating, a wetting agent, a package comprising a wetted hydrophilic coating, and a method of sterilizing a wetted hydrophilic coating.

Abstract: The present patent application relates to a novel coating system, coated compositions with such a coating system, as well as to the use of such compositions in the production food, feed, dietary supplements and/or pharmaceutical products, as well as to food, feed, dietary supplements and/or pharmaceutical products comprising such compositions.

Abstract: Silicone containing reactive monomers with hydrophilic end-groups of formula I useful in the manufacture of biocompatible medical devices are disclosed, wherein R1 is H or CH3, a is 0 or 1, p is an integer from 1 to 6, q is an integer from 1 to 3 and for each q, the end groups R51, R52, R53 are independently an alkyl, alkyl ether, urethane, trimethylsiloxy group, or a substituted or non-substituted aromatic group and at least one of them has a hydrophilic group Z attached wherein said hydrophilic group Z is selected from the group of poly(ethylene glycol), poly(propylene glycol), poly(ethyl oxazoline), poly(methyl oxazoline), hyaluronic acid, or combinations thereof, preferably to the terminal end of R51, R52, R53, X is O or NR54, where R54 is H or a monovalent alkyl group with 1 to 4 carbons, n is an integer from 1 to 100, R2 and R3 is independently an alkyl, alkyl ether, trimethylsiloxy group, or a substituted or non-substituted aromatic group, preferred R2 and R3 include methyl, ethyl, trimethylsiloxy

Abstract: Intravaginal drug delivery device comprising at least one pharmaceutically active substance, and a polyurethane copolymer, wherein the copolymer has the structure according to formula (I): Also, method comprising administering one or more pharmaceutically active substances to a patient in need thereof.

Abstract: The invention relates to a coating composition comprising an inorganic oxide precursor AMOx based on at least one inorganic element A selected from the group consisting of aluminum, silicium, titanium, zirconium, niobium, indium, tin, antimony, tantalum, and bismuth; and an inorganic oxide precursor BMOx based on at least one inorganic element B selected from the group consisting of scandium, yttrium, lanthanum, and the lanthanoids; wherein AMOx and BMOx are capable of forming a mixed inorganic oxide. A coating made from this composition shows enhanced resistance to hydrolysis. The invention also relates to a process for applying a coating on a substrate using such composition, more specifically to a liquid coating composition for use in a process of applying an anti-reflective coating on transparent substrate; to a coated substrate obtained with such process, and to an article, like a solar panel, comprising such coated substrate.