Abstract: A system for detecting symptoms of hypoglycemia in a diabetic individual. The system comprises a temperature sensing system, a conductance sensing system, a trending system, a threshold system, and an alarm system. The temperature sensing system produces a temperature signal representative of a skin temperature of the diabetic individual. The conductance sensing system produces a conductance signal representative of a level of perspiration of the diabetic individual. The trending system produces a slope estimate representative of a rate of change of the skin temperature over a predetermined interval in response to the temperature signal. The threshold system produces a slope threshold representative of a hypoglycemic decline in skin temperature observed over the predetermined interval in response to the conductance signal and to the temperature signal. The alarm system produces an indication of the presence of hypoglycemic symptoms in response to the slope estimate and the slope threshold.