Abstract: A set for conveying blood between a patient and blood treatment apparatus such as a dialyzer. The set comprises a blood flow conduit, a connector for a patient's vascular system, and a connector for the dialyzer. A portion of the conduit comprises an enlarged-diameter, tubular pump segment connected at each pump segment end with a connector. The connectors also are each connected in substantially straight-line relation to other portions of the blood flow conduit. Typically, both connectors also each connect to a branch line in a relation substantially parallel to the connection of the other blood flow conduit portion and the connected tubular pump segment. Thus, the set is more capable of being rolled up and packaged in an automated manner, since it can be free of branching connections which connect at a substantial angle to the overall axis of the set.

Abstract: An extracorporeal blood set may be primed with physiological solution for use in a blood transporting process such as hemodialysis. The set comprises tubing having a patient connector on an end thereof, and a first branch tube in connection with a source of the solution. The branch tube connects with the set between the ends of the set. The branch tube also connects with further branch tubing, having a second connector which is capable of sealing connection with the patient connector. The method comprises the steps of connecting the patient connector and the second connector to form a closed loop of tubing. One then passes the solution from the source in flow through the first branch tube and further branch tubing to fill them and the set tubing with the solution. One then disconnects the patient connector for subsequent connection with the vascular system of a patient.

Abstract: Pressure is sensed in blood flow tubing by placing an aqueous, preferably isotonic, substantially cell-free solution into branch connection tubing that connects in branching relation with the blood flow tubing at one end. The branch connection tubing also connects in use with a pressure transducer unit at its other end. An air volume is maintained, occupying a portion of the branch connection tubing which is adjacent to the other end. One flows positively or negatively pressurized blood through the blood flow tubing, with the result that the pressure of the blood is communicated through the aqueous solution and the air volume in the branch connection tubing to the pressure transducer unit, with the blood being spaced from the air volume. Preferably, substantially all of the branch connection tubing containing the aqueous solution and air volume has an inner diameter of substantially no more than 5 mm.

Abstract: Access pressure for the vascular system is measured through a first tube, which is connected to the vascular system of a patient. The method comprises the following steps: connecting one end of pressure tubing to an outer end of the first tube with a member blocking the flow of blood through at least part of the pressure tubing, while permitting the passage of air therethrough, to attenuate pressure pulses through the tubing. One connects the other end of the tubing to a pressure gauge. Thus, pressure sensed from the vascular system is read by the gauge. Preferably, the internal volume of the pressure tubing is less than the internal volume of the first tube. Thus, pressurized blood entering the first tube as the pressure is read does not advance completely through the first tube.

Abstract: A blood processing system for transport of blood between a patient and a blood processing unit includes (i) an arterial set 10 having a patient connector 15 at one end and a dialyzer connector 32 at the other end, and (ii) a venous set 14 having a patient connector 17 at one end and a dialyzer connector 33 at the other end. The dialyzer connectors and the patient connectors are adapted to be connected via interconnectors 19, 19d to form a loop so that the blood processing system can be primed without the dialyzer therein.

Abstract: A tubular set is provided for use with extracorporeal treatment of blood. The set comprises: a flow reversing valve having a patient arterial line and a patient venous line each separately connected to one side of the valve. A unit arterial line and a unit venous line are each separately connected to the other side of the valve. The patient arterial line connects with the unit arterial line in a first position of a valve, and the patient venous line connects with the unit venous line in the same first valve position. The patient arterial line connects with the patient venous line in a second position of a valve, while the patient venous line connects with the unit arterial line in the same second valve position. The flow reversing valve is movable between the first and second positions by relative rotation of part of the valve and adjacent portions of the respective lines.

Abstract: A flow-through blood treatment device such as a hemodialyzer comprises a housing, a blood inlet, a blood outlet, and at least one membrane in the housing defining a blood flow path between the blood inlet and outlet on one side of the membrane, plus a second flow path defined on the other side of the membrane. At least one of the blood inlet and outlet is connected to blood flow tubing, which blood flow tubing carries a connector spaced from the housing for access to the vascular system of a patient. The blood flow tubing also defines at least one connection site along its length permitting repeated, temporary connection and subsequent disconnection with branch conduits, for connection with sources of additive solutions or measuring devices. Typically, the blood flow tubing is free of permanently attached, flexible branch tubings a method of use in disclose.

Abstract: An extracorporeal blood set may be primed with physiological solution for use in a blood transporting process such as hemodialysis. The set comprises tubing having a patient connector on an end thereof, and a first branch tube in connection with a source of the solution. The branch tube connects with the set between the ends of the set. The branch tube also connects with further branch tubing, having a second connector which is capable of sealing connection with the patient connector. The method comprises the steps of connecting the patient connector and the second connector to form a closed loop of tubing. One then passes the solution from the source in flow through the first branch tube and further branch tubing to fill them and the set tubing with the solution. One then disconnects the patient connector for subsequent connection with the vascular system of a patient.

Abstract: A cannula or needle set for fluid flow connection with the vascular system of a patient. In one embodiment, the set comprises a hollow, hypodermic needle having a longitudinal axis and a sharp end for skin penetration and connection with the vascular system. A hollow hub carries the needle at a needle opposite to the sharp end. A fluid flow port is defined in the hub at a position laterally spaced from the axis of the needle. An injection site aperture is defined in the hub at a position centrally intersected by the needle axis, the injection site aperture being closed by a recloseable, needle-penetrable wall.

Abstract: A tissue penetrating cannula comprises a tube having a sharp end formed by a first cut surface defining an acute angle to the longitudinal axis of the tube and forming a generally oval tube edge defining a similar acute angle to the longitudinal axis. A second cut surface is defined along a right hand forward portion of the oval tube edge, and a third cut surface is defined along a left hand forward portion of the oval tube edge. A second and third cut surfaces define between them a forward cutting surface in the tube edge. A fourth cut surface at the point intersects the second and third cut surfaces to cause the cutting surface to be spaced inwardly of the tube outer wall. Fifth and sixth cut surfaces are provided to respectively flatten the tube edge between the first and second surfaces and the first and third surfaces.

Abstract: A combined arterial-venous blood flow set comprises connected lengths of flexible tubing for receiving blood from a patient, for conveying the blood to a blood processing device such as a dialyzer or an LDL filter, and for returning the blood to the patient. An optional first bubble trap chamber is connected in series flow between two of the lengths of tubing at a flow position downstream from the patient and upstream from the blood processing device. A second bubble trap chamber is connected in series flow between two of the lengths of tubing at a flow position downstream from the blood processing device and upstream from the patient. A first portion of the tubing which is in a flow position upstream from the blood processing device extends by the second bubble trap chamber, and is physically, laterally connected to it without direct flow connection. This helps to stabilize the positioning of components of the flow set and to reduce confusion in set-up and priming.

Abstract: A molded squeeze clamp for tubing which comprises a strip of plastic having first and second ends, the strip being bent back on itself so that the ends are adjacent to each other in the manner of a Halkey-Roberts clamp. The first strip end defines a first latch, for engagement and releasable locking with the second end, and the second end defines a second latch for locking with the first latch. The first end also defines a first projection extending towards the second end to reduce or eliminate a gap between the first and second ends when the clamp is in its unstressed, as-molded, open configuration. The second end defines a second projection to facilitate manual opening of the clamp, the second projection extending in substantially longitudinal relation to the axis of tubing carried in the squeeze clamp.

Abstract: A needle point protection sheath comprises a protector tube having a bore for receiving a hollow needle plus a needle hub within the bore. The protector tube has closure cap at one end thereof and has a retention member at the other end to engage an end of the hub, to prevent the hub from passing out of the other tube end. The cap may carry a sleeve having a needle-pierceable wall at its inner end, or a mass of resilient material which is capable of being penetrated by the needle as the cap is closed, to seal the needle tip and thus prevent the spilling of blood residue when a blood collection needle is being enclosed for protection.

Abstract: A blood processing system (e.g. a dialysis system) having a blood processing unit (e.g. a hemodialyzer) and tubular arterial and venous blood flow sets (10, 14) may be primed by temporarily connecting together the ends of the sets and then passing priming solution in a first flow direction (44) that is retrograde to the normal flow of blood. This causes the priming solution to enter an in-line chamber (64) carried by one of the sets. At the same time, air is removed through a port (62). Preferably, the chamber includes a filter (65). In another step, priming solution is passed through the sets in a second flow direction (42), opposite the first flow direction, while continuing to remove air through the port. Preferably, the solution is passed in the first flow direction by gravity and in the second flow direction with a pump (26a). The solution can also be passed in both directions simultaneously.

Abstract: A tubular set is provided for the extracorporeal treatment of blood, for example hemodialysis. The set comprises a patient arterial line and a patient venous line, each line having a patient connector at one end thereof. Each patient line connects at its other end to a reversing flow valve. The valve also connects to respective first ends of a blood processing unit arterial line and a blood processing unit venous line. Each of the unit lines carry a connector at ends opposed to the first ends for connection respectively to arterial and venous ports of a blood processing device, typically a dialyzer. The reversing flow valve has a first position that respectively connects the patient and unit arterial lines with the patient and unit venous lines. The reversing flow valve has a second position that connects the patient arterial line with the unit venous line, and the unit arterial line with the patient venous line.

Abstract: A flow through bubble trap for fluid flow lines comprises a chamber-defining wall and a flow inlet/outlet tube at least substantially extending through the chamber and open at opposed tube ends to respectively define an inlet and an outlet of the bubble trap. The tube defines a flow inlet port and a flow outlet port within the chamber interior. A flow blocking partition closes the bore of the tube between the flow inlet and outlet ports. Additionally, the chamber defining wall carries a retaining-sealing member for removable, sealing connection with a tube connector of a fluid flow line. The retaining-sealing member is free of fluid flow connection with the interior of the chamber defined by the wall, and thus serves as a seal for connectors on tube ends of a set carrying the bubble trap. Also, the chamber defining wall has a bottom wall that defines a third port.

Abstract: Blood lines for hemodialysis and other blood handling procedures may be reused by placing connectors intermediately along the length of the blood lines so that the lines can be disconnected to separate out reusable portions thereof. Specifically, the bulk of the blood lines used may comprise branchless lengths of tubing which are easily reusable, and may be cleaned and stored along with a dialyzer or similar device by connection to a conventional reuse machine. Also, the connectors on the blood lines which are reused may have first and second sealing surfaces. The first sealing surfaces are used in the connections made to form the blood line in its normal form for use. Then, during cleaning and sterilization for reuse, the reusable connectors can connect first and second lengths of blood lines together making use of a second sealing surface, in which the first sealing surfaces are exposed to cleaning/storing solution to cause cleaning and antibacterial action on the first sealing surfaces.

Abstract: A squeeze clamp for flexible tubing comprises a strip of plastic which is bent back on itself so that the ends are adjacent to each other. The strip defines a pair of spaced apertures to permit a flexible tube to extend through and be carried by the clamp. First and second latches at the respective ends can hold the clamp in a closed position, or it can spring outwardly into an open position. The apertures extend laterally through a first side edge of the strip, with the apertures thus being each located next to a narrow strip portion connected to wider strip portions on either side of the narrow strip portion. At least one of the narrow strip portions extends laterally outwardly beyond the side edge of the rest of the plastic strip for strengthening of the narrow strip portion, to reduce problems of involuntary twisting or torsion as the clamp is closed.

Abstract: An injection site for passing a needle into an enclosed space surrounded by a wall, typically defined by a tubular section incorporated in a tubular set. An aperture in the wall communicates between the enclosed space and the exterior, having an elastic, needle-pierceable member such as a plug occluding the aperture. The plug is exposed to the exterior on one side and defines a route of needle access through the plug and aperture to the enclosed space. A first flange is positioned adjacent to the plug and extends transversely outwardly from the plug. The first flange carries a second flange, which extends longitudinally relative to the plug, and is spaced transversely outwardly from the plug to define a catch area for needles, which catch area surrounds the plug.

Abstract: A needle point protection sheath comprises a protector tube having a bore for receiving a hollow needle plus a needle hub within the bore. The protector tube has a closure cap at one end thereof and has a retention member at the other end to engage an end of the hub, to prevent the hub from passing out of the other tube end. The cap may carry a sleeve having a needle-pierceable wall at its inner end, or a mass of resilient material which is capable of being penetrated by the needle as the cap is closed, to seal the needle tip and thus prevent the spilling of blood residue when a blood collection needle is being enclosed for protection.