Patents Assigned to DTherapeutics, LLC
  • Patent number: 10314686
    Abstract: The disclosure of the present application provides devices, systems, and methods for replacing damaged or compromised blood vessels and engineering luminal grafts for various medical applications. Such devices are capable of providing viable, small-diameter grafts for use in anastomotic procedures and comprise a tubular construct consisting largely of elastin and some collagen fibers and having at least one diameter of less than or equal to about 5 mm. In one exemplary embodiment, the graft comprises at least one layer of pulmonary ligament tissue and/or pulmonary visceral pleura. Systems and methods for the manufacture of the graft are also provided, which include the use of at least one layer of tissue, a mandrel and a closure mechanism.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: June 11, 2019
    Assignee: DTherapeutics, LLC
    Inventors: Ghassan S. Kassab, Xiao Lu
  • Patent number: 10265100
    Abstract: Transradial access devices, systems, and methods. An exemplary device of the present disclosure for providing access to a vessel or other luminal organ and to prevent overperforation of the same comprises a needle having a needle tip and at least one current element positioned thereon or embedded therein at or near the needle tip, a sheath positioned around at least part of the needle, and a protractor in communication with the needle, whereby engagement of the protractor causes the needle tip to protract from the sheath through the aperture, and whereby release of the protractor causes the needle tip to retract through the aperture into the sheath. Activation of the at least one current element can facilitation vasodilation of the vessel or other luminal organ.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: April 23, 2019
    Assignee: DTherapeutics, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 10219828
    Abstract: Devices, systems, and methods for transradial access. In at least one embodiment of a device for providing access to a vessel or other luminal organ of the present disclosure, the device comprises a needle having a needle tip, a sheath positioned around at least part of the needle, the sheath defining an aperture at a distal sheath end, and a protractor in communication with the needle, whereby engagement of the protractor causes the needle tip to protract from the sheath, and whereby release of the protractor causes the needle tip to retract into the sheath.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: March 5, 2019
    Assignee: DTherapeutics, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 10217220
    Abstract: Methods for the determination of transit time in circulatory systems and applications of the same. In at least one embodiment, the method includes the steps of obtaining a biological tree image showing a vasculature of at least part of a mammalian biological tree including at least a vessel segment, determining a transit time in the vessel segment, determining a blood volume in the vessel segment, determining a blood volume in a first vascular tree comprising the vessel segment, and calculating a transit time in the first vascular tree based upon the transit time through the vessel segment, the blood volume in the vessel segment, and the blood volume in the first vascular tree.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: February 26, 2019
    Assignee: DTherapeutics, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 9775576
    Abstract: Methods are provided for determining flow resistance within at least a portion of a vessel, whereby at least a partial biological tree image is obtained and resistance is calculated therefrom based upon at least the length of a defined vessel portion and a diameter of a stem vessel at a location proximal to a vessel crown. Methods are also provided for determining vessel volume, whereby at least a partial biological tree image is obtained and cumulative crown volume is calculated based on at least the diameter and length of the stem segment.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: October 3, 2017
    Assignee: DTherapeutics, LLC
    Inventors: Ghassan S. Kassab, Yunlong Huo
  • Patent number: 9591994
    Abstract: Systems and methods to obtain a myocardial mass index indicative of an at-risk myocardial region. In at least one embodiment, a method for diagnosing a risk of cardiac disease is provided, the method comprising the steps of identifying a luminal cross-sectional area of a side branch vessel, identifying a luminal cross-sectional area of a main artery most proximal to the side branch vessel, determining a myocardial region at risk for infarct from side branch occlusion relative to a mass perfused by the most proximal artery, wherein such region is based on a relationship between the cross-sectional areas of the side branch and the most proximal main artery, and diagnosing a risk of cardiac disease based on a diameter of the side branch and the size of the myocardial region at risk for infarct perfused by the side branch.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: March 14, 2017
    Assignee: DTherapeutics, LLC
    Inventor: Ghassan S. Kassab
  • Publication number: 20170043145
    Abstract: Devices, systems, and methods for localized drug delivery. In at least one embodiment of a method of localized drug delivery, the method comprises the steps of placing a resorbable device within a tube, introducing the tube within a mammalian body at or near a tissue and/or organ within the mammalian body, and anchoring the resorbable device to the tissue and/or organ. Devices and systems useful for performing such a method are also disclosed herein, wherein an exemplary device comprises at least one drug release portion having at least one drug to be released over time and a binder intermixed with the at least one drug, and at least one resorbable anchor portion coupled to the at least one drug release portion.
    Type: Application
    Filed: September 17, 2013
    Publication date: February 16, 2017
    Applicant: DTherapeutics, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, SR.
  • Publication number: 20160184567
    Abstract: Devices, systems, and methods for localized drug delivery. In at least one embodiment of a method of localized drug delivery, the method comprises the steps of placing a resorbable device within a tube, introducing the tube within a mammalian body at or near a tissue and/or organ within the mammalian body, and anchoring the resorbable device to the tissue and/or organ. Devices and systems useful for performing such a method are also disclosed herein, wherein an exemplary device comprises at least one drug release portion having at least one drug to be released over time and a binder intermixed with the at least one drug, and at least one resorbable anchor portion coupled to the at least one drug release portion.
    Type: Application
    Filed: September 17, 2013
    Publication date: June 30, 2016
    Applicant: DTherapeutics, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, SR.
  • Patent number: 9179996
    Abstract: Method and apparatus for mapping the shape and dimensions of a 3-dimensional body, by applying to the 3-dimensional body a stretchable covering configured and dimensioned such that in its stretched condition it tightly engages and conforms to the shape and dimensions of the 3-dimensional body to be mapped. The stretchable covering carries a plurality of reference devices, such as bands and/or markers which are at known or determinable reference locations in an initial condition of the covering, and which change their locations in the stretched condition of the stretchable covering according to the shape and dimensions of the 3-dimensional body covered thereby. The locations of the markers on the stretchable covering are determined after the stretchable covering has been applied to the 3-dimensional body, and are utilized to produce a map of the shape and dimensions of the 3-dimensional body.
    Type: Grant
    Filed: May 1, 2006
    Date of Patent: November 10, 2015
    Assignee: DTherapeutics, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 9089282
    Abstract: Devices and systems to size a luminal organ. At least some embodiments include a catheter comprising an outer elongate tube, an inner elongate tube disposed within the outer elongate tube, a proximal balloon attached to the outer elongate tube, a distal balloon having a first end attached to the outer elongate tube and a second end attached to the inner elongate tube, electrodes positioned on the outer elongate tube, and a pressure transducer positioned on the outer elongate tube.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: July 28, 2015
    Assignee: DTherapeutics, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 8998816
    Abstract: The present invention discloses devices, systems and methods for the isovolumic measurement of vasoactivity in a blood vessel (3). The length and volume of the blood vessel (3) are maintained constant while a chemical or pressure is exposed to the blood vessel (3). The reaction of the blood vessel (3) to the chemical or physical stimuli is measured by internal lumen pressure changes.
    Type: Grant
    Filed: May 1, 2006
    Date of Patent: April 7, 2015
    Assignee: DTherapeutics, LLC
    Inventors: Ghassan S. Kassab, Xiao Lu
  • Patent number: 8992444
    Abstract: Devices, systems, and methods for determining isometric and isotonic activity of luminal organs. In an exemplary method for detecting a luminal organ response to mechanical stimulation of the present disclosure, the method comprises the steps of maintaining a luminal organ at a first internal pressure, increasing the first internal pressure of the luminal organ, and measuring a first organ parameter change in response to the increase in internal pressure.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: March 31, 2015
    Assignee: DTherapeutics, LLC
    Inventors: Ghassan S. Kassab, Xiao Lu
  • Publication number: 20150080855
    Abstract: Devices, systems, and methods for localized drug delivery. In at least one embodiment of a method of localized drug delivery, the method comprises the steps of placing a resorbable device within a tube, introducing the tube within a mammalian body at or near a tissue and/or organ within the mammalian body, and anchoring the resorbable device to the tissue and/or organ. Devices and systems useful for performing such a method are also disclosed herein, wherein an exemplary device comprises at least one drug release portion having at least one drug to be released over time and a binder intermixed with the at least one drug, and at least one resorbable anchor portion coupled to the at least one drug release portion.
    Type: Application
    Filed: September 17, 2013
    Publication date: March 19, 2015
    Applicant: DTherapeutics, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, SR.
  • Patent number: 8913060
    Abstract: An accurate analysis of the spatial distribution and intravascular pattern of blood flow in any organ must be based on detailed morphometry (diameters, lengths, vessel numbers, branching pattern, branching angles, etc.) of the organ vasculature. Despite the significance of detailed morphometric data, there is relative scarcity of database on vascular anatomy, mainly because the process is extremely labor intensive. Novel methods in the form of a segmentation algorithm for semi-automation of morphometric data extraction are provided. The extraction algorithm is based on a topological analysis of a vector field generated by the normal vectors of the extracted vessel wall. With this approach, special focus is made on achieving the highest accuracy of the measured values, with excellent results when compared to manual measurements of the main trunk of the coronary arteries with microscopy.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: December 16, 2014
    Assignee: DTherapeutics, LLC
    Inventors: Ghassan S. Kassab, Thomas Wischgoll
  • Patent number: 8903472
    Abstract: In at least one embodiment, a method for diagnosing vascular disease is provided, the method comprising the steps of obtaining a vessel image showing a vasculature of a vessel, identifying at least two measurements from the vasculature of the vessel, the measurements relating to at least two parameters, calculating a relationship between the at least two parameters from the at least two measurements to generate one or more vasculature data points, and comparing the one or more vasculature data points to data relative to a model vasculature to determine the extent of vascular disease. In an another embodiment, a method for diagnosing vascular disease in a patient's vascular tree is provided, the method comprising the steps of generating a model vascular tree from a minimum energy hypothesis calculation, and comparing the patient's vascular tree with the model vascular tree to determine the extent of vascular disease.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: December 2, 2014
    Assignee: DTherapeutics, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 8894681
    Abstract: Devices, systems, and methods for controlling local blood pressure. In an exemplary embodiment of a device for exposing a blood vessel to increased pressure of the present disclosure, the device comprises an anchor configured for placement into a blood vessel and to expand independently from a particle held from flowing away by the anchor, the particle configured to gradually expand due to exposure to blood flow.
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: November 25, 2014
    Assignee: DTherapeutics, LLC
    Inventor: Ghassan S. Kassab
  • Publication number: 20140257078
    Abstract: Methods are provided for determining flow resistance within at least a portion of a vessel, whereby at least a partial biological tree image is obtained and resistance is calculated therefrom based upon at least the length of a defined vessel portion and a diameter of a stem vessel at a location proximal to a vessel crown. Methods are also provided for determining vessel volume, whereby at least a partial biological tree image is obtained and cumulative crown volume is calculated based on at least the diameter and length of the stem segment.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 11, 2014
    Applicant: DTherapeutics, LLC
    Inventors: Ghassan S. Kassab, Yunlong Huo
  • Patent number: 8670943
    Abstract: Methods are provided for determining flow resistance within at least a portion of a vessel, whereby at least a partial biological tree image is obtained and resistance is calculated therefrom based upon at least the length of a defined vessel portion and a diameter of a stem vessel at a location proximal to a vessel crown. Methods are also provided for determining vessel volume, whereby at least a partial biological tree image is obtained and cumulative crown volume is calculated based on at least the diameter and length of the stem segment.
    Type: Grant
    Filed: August 12, 2008
    Date of Patent: March 11, 2014
    Assignee: DTherapeutics, LLC
    Inventors: Ghassan S. Kassab, Yunlong Huo
  • Publication number: 20130317392
    Abstract: Valve aperture sizing devices and methods. In an exemplary method to size a valve aperture, the method comprises introducing at least part of a first device into a luminal organ at a valve aperture, the first device having a balloon positioned thereon, inflating the balloon within the valve aperture until a point of apposition is achieved, and obtaining a first valve aperture measurement based upon the point of apposition.
    Type: Application
    Filed: March 26, 2013
    Publication date: November 28, 2013
    Applicant: DTherapeutics, LLC
    Inventor: DTherapeutics, LLC
  • Patent number: 8535260
    Abstract: Devices, systems, and methods for localized drug delivery. In at least one embodiment of a method of localized drug delivery, the method comprises the steps of placing a resorbable device within a tube, introducing the tube within a mammalian body at or near a tissue and/or organ within the mammalian body, and anchoring the resorbable device to the tissue and/or organ. Devices and systems useful for performing such a method are also disclosed herein, wherein an exemplary device comprises at least one drug release portion having at least one drug to be released over time and a binder intermixed with the at least one drug, and at least one resorbable anchor portion coupled to the at least one drug release portion.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: September 17, 2013
    Assignee: DTherapeutics, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, Sr.