Abstract: A patient pain management system and method that includes assessing patient history; determining a drug treatment in response to assessing patient history; and repeatedly reassessing the pain and assessing side-effects and adjusting the drug treatment to minimize patient pain. The system includes pain assessment tools for assessing patient pain and treatment history; treatment choice tools for determining a pain treatment protocol; pain reassessment tools for reassessing patient pain in response to the pain treatment protocol; and side-effect assessment tools for assessing side-effects experienced by the patient to enable a caregiver to continuously reassess patient pain and comfort and adjust treatment to minimize patient pain and discomfort.