Patent number: 5179117
Abstract: The compounds of the described invention are potent ACAT inhibitors and are useful in pharmaceutical compositions for the treatment of atherosclerosis and have the formulas: ##STR1## when Q is a double bond wherein: R.sup.1 and R.sup.2 are each H, C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.10 cycloalkyl, C.sub.4 -C.sub.10 -C.sub.10 cyloalkylalkyl, C.sub.7 -C.sub.14 aralkyl, 2-,3- or 4-pyridinyl, 2-thienyl, 2-furanyl, phenyl optionally substituted by F, Cl, Br, OH, CN, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.8 alkyl, CH.sub.3 S(O).sub.r, NO.sub.2, CF.sub.3 NR.sup.7 R.sup.8 or NR.sup.7 C(O)R.sup.8 ;R.sup.3 is N.C.sub.1 -C.sub.6 alkyl, allyl or benzyl or phenyl both optionally substituted F, Cl, CH.sub.3, CH.sub.3), or CF.sub.3 ; C.sub.1 -C.sub.4 carboalkyl;R.sup.4 is H, C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.4 -C.sub.10 cycloalkylalkyl, C.sub.1 -C.sub.3 perfluoroalkyl or, benzyl or phenyl both optionally substituted by C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.4 -alkoxy, F, Br, Cl, NH.sub.
Type:
Grant
Filed:
December 20, 1991
Date of Patent:
January 12, 1993
Assignee:
Du Pont Merck Pharmaceutical Company
Inventor:
Thomas P. Maduskuie, Jr.