Patents Assigned to Du Pont Merck Pharmaceutical
  • Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
    Patent number: 5036092
    Abstract: Aminomethyl oxooxazolidinyl aza cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-3-aza-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetam ide, possess useful antibacterial activity.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: July 30, 1991
    Assignee: Du Pont Merck Pharmaceutical
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
    Patent number: 5036093
    Abstract: Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-3-aza-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetam ide, possess useful antibacterial activity.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: July 30, 1991
    Assignee: Du Pont Merck Pharmaceutical
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Method of using phenylquinolinecarboxylic acids and derivatives for lymthoid leukemia treatment in a mammal
    Patent number: 5032597
    Abstract: Phenylquinolinecarboxylic acids and derivatives thereof, such as 2-(2'-fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid, or a sodium or potassium salt thereof, are useful as tumor inhibiting agents.
    Type: Grant
    Filed: March 26, 1987
    Date of Patent: July 16, 1991
    Assignee: Du Pont Merck Pharmaceutical
    Inventor: David P. Hesson
  • Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
    Patent number: 5032605
    Abstract: Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-oxa or thia-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetamide, possess useful antibacterial activity.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: July 16, 1991
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Stable human cell lines expressing an indicator gene product under virus-specific genetic controls
    Patent number: 5026635
    Abstract: The invention relates to stable mammalian cells lines having integrated in their genome two heterologous DNA sequences, a first DNA sequence which expresses a trans-acting regulatory protein, and a second DNA sequence which expresses a desired protein, said second DNA sequence being linked to a target DNA regulatory control sequence which is responsive to the expressed trans-acting regulatory protein.
    Type: Grant
    Filed: April 26, 1990
    Date of Patent: June 25, 1991
    Assignee: Du Pont Merck Pharmaceutical
    Inventors: Blair Q. Ferguson, Lee T. Bacheler, Stephen R. Petteway, Russell H. Neubauer
  • 2-substituted-1-naphthols as 5-lipoxygenase inhibitors
    Patent number: 5026759
    Abstract: 2-Substituted-1-naphthols are 5-lipoxygenase inhibitors which make them useful in the treatment of inflammation, obstructive lung diseases and/or psoriasis. Useful 2-substituent groups are alkyls, alkenyls, alkynyls, cycloalkyls, cycloalkenyls, the groups CH.sub.2 --C.tbd.C--(CH.sub.2).sub.m R.sup.5 and CH.dbd.CH--(CH.sub.2).sub.n R.sup.5 (where m is 1-4, n is 0-3 and R.sup.5 includes phenyl, COOR.sup.9, where R.sup.9 is H or alkyl of 1-4 carbons, AR.sup.6 (where A is a methylene chain and R.sup.6 is a variety of groups including Cl, Br, I, CHO, CN, COOR.sup.9, NH.sub.2, SC(NH)NH.sub.2, phenyl, P(O)(OR.sup.9).sub.2, etc.), and CHR.sup.7 R.sup.21 (where R.sup.7 is a variety of aromatic and heterocyclic groups and R.sup.21 is H, optionally substituted phenyl and a variety of heterocyclic groups).
    Type: Grant
    Filed: December 4, 1989
    Date of Patent: June 25, 1991
    Assignee: Du Pont Merck Pharmaceutical
    Inventor: Douglas G. Batt