Abstract: A microfluidic array supporting a lipid bilayer assembly on which membrane proteins can be assembled is described. The array is formed from a hydrophilic polymeric substrate or metal substrate comprising a planar surface with a plurality of individual spherical depressions formed therein. Each of the depressions are configured to have a diameter greater than 1 ?m and containing an aqueous solution. Across each of the depressions is provided a lipid layer. Each of the plurality of individual depressions comprise arcuate side walls extending downwardly into the substrate from the planar surface.

Abstract: A particle capture system that can be used in the context of a lab-on-a-chip platform for particle- and cell-based assays is described. The system comprises a capture chamber comprising a plurality of capture sites, the capture sites defining a capture area configured to receive individual particles travelling within the capture chamber. By rotating the chamber, the individual particles are biased towards the capture sites where they may be captured.

Abstract: A gallium silica glass composition is described. The glass can be used in variety of biomedical applications.

Abstract: An inspection device is provided which comprises a receiving member defining an open cell for receiving a target therein. An optical excitation input is in optical communication with the cell for exciting the target. At least one acoustic pickup is in acoustic communication with the cell for picking up acoustic energy resultant from excitation of the target. A recorder is provided for recording the acoustic energy picked up from the at least one acoustic pickup for facilitating structural analysis of the target.

Abstract: The present invention relates to a method, including a diagnostic method, for characterising platelets. More particularly, the invention relates to methods for characterising platelets by immobilising platelets on a substrate for detection and subsequent characterisation, and to devices on which such a method may be practiced. The method comprises the steps of:—a. contacting a substrate that includes a plurality of discrete platelet-binding zones having a surface area of 7850 ?m2 orless with a fluid composition comprising platelets; and b. detecting platelets bound to the platelet-binding zones and thereby characterising platelets.

Abstract: A system and method for detecting the location of a mobile device within an area, uses a plurality of wireless signals sent to or received by the device to derive a first estimate of the position of the device. This position estimate is then adjusted using a probabilistic model of the area, where the area is divided into zones or regions, and where each region is assigned a weighting according to the probability of the device being located in that region taking account of the prior position of the device. By using the weightings to adjust the position estimate, false or ambiguous position estimates are discounted and the true position of the device is more reliably detected. The method also includes techniques to take account of different wireless characteristics of different devices when each is supplied with the same model.

Abstract: An analysis technique for determining complex qualitative and quantitative contributions to the viscoelastic properties of a film in contact with or in close proximity to a surface. Based on an assumption that the viscosity of the surface of a fluid film that is opposite to a surface at which the film interacts with the surface changes negligibly, the invention derives representative parameters for the mass and elasticity of the film as a whole as well as a qualitative parameter that is representative of a typical single particle within the film. These representative parameters can be used to classify the film, and in the case of blood or other bodily fluids, can be used to identify pathological conditions. The invention is applicable to all types of liquids that physically interact with a surface, e.g. by exhibiting a coupling effect, adhesion or the like.

Abstract: The present application relates generally to electrochemical devices, for example proton exchange membrane fuel cells or electrolysers. The present application employs a metal foam as a common fluid flow manifold between adjacent fuel cells and avoids the use of expensive metal end plates. The common fluid flow manifold is provided by the metal foam with no separator/gas barrier provided.

Abstract: A system for sensing and measuring ammonia in a breath sample is described. The system includes a sampling means for capturing and directing a breath sample from a subject to an ammonia sensor, the ammonia sensor including a conducting polymer polyaniline sensor. The sampling means includes a breath sample capture chamber, the chamber having an inlet and outlet, the inlet having a first valve through which a breath is exhaled into the sample capture chamber, the outlet having a second valve through which breath surplus to the volume of the chamber is expelled, to provide capture of a breath sample of predefined volume.

Abstract: A system and method for detecting the location of a mobile device within an area, uses a plurality of wireless signals sent to or received by the device to derive a first estimate of the position of the device. This position estimate is then adjusted using a probabilistic model of the area, where the area is divided into zones or regions, and where each region is assigned a weighting according to the probability of the device being located in that region taking account of the prior position of the device. By using the weightings to adjust the position estimate, false or ambiguous position estimates are discounted and the true position of the device is more reliably detected. The method also includes techniques to take account of different wireless characteristics of different devices when each is supplied with the same model.

Abstract: The present application provides an optical comb source in which the comb is produced by seeding a gain switched Fabry-Pérot laser with light from a single mode laser, while at the same time driving the Fabry-Pérot laser with a DC bias and RF signal.

Abstract: An object/test material interaction microti iridic device comprising a sample inlet adapted to receive a fluid sample comprising a plurality of objects, an outlet adapted to output the fluid sample from the device, at least one internal surface defining a flow cavity within the device, wherein the flow cavity extends between and is connected to the sample inlet and the outlet for flow of the fluid sample through the flow cavity, the flow cavity comprises a test area to which at least one test material is attached and which is situated in the flow cavity for flow of the fluid sample over the test area, and the flow cavity has an aspect ratio which, when the flow cavity is substantially filled by the fluid sample, provides a substantially constant shear force between the test area and the fluid sample flowing over the test area. The invention further comprises a system incorporating the device, methods of use of the device and system, and methods of analyzing interactions.

Abstract: The present invention is directed to a lateral flow assay device for the monitoring and measuring of coagulation and method thereof. Ideally, the invention is directed to a lateral capillary flow device for the monitoring and/or measurement of coagulation in a liquid sample wherein the device comprises a non-porous substrate with a zone for receiving a sample and a defined flow path zone wherein a clotting agent is deposited on at least part of the defined flow path zone to accelerate the coagulation of the liquid sample, enable the formation of an evenly distributed clot along the defined flow path zone and to result in the change in flow rate or cessation of flow of the liquid sample along the defined flow path zone.

Abstract: Microfluidic devices and in particular microfluidic devices incorporating a valve for selectively controlling the flow of a fluid within the microfluidic device are described. Specific examples of a microfluidic device are described, comprising a sacrificial valve, desirably one that is dissolvable on contact with a fluid or that is configured to disintegrate or dissolve on experiencing a predetermined pressure.

Abstract: The present invention describes a spatial addressing technique that uses a very high-density micro-pore array for high-throughput screening of biological interactions. The therapeutic, diagnostic and drug-discovery implications of being able to identify, select and characterize specific protein-protein, protein-DNA and/or protein-carbohydrate interactions from heterogeneous populations of millions (to billions) of cells is discussed. Importantly, this technique possesses the screening and selection capacity of current display-based screening systems (i.e., millions-billions) but with greater efficiency and shorter time.

Abstract: A sensor comprising a substrate (100) having a first surface (105) and a second surface (110) is described. The first surface has at least one sensor site (115) provided thereon. The substrate is configured such that on excitation of a sample provided at the sensor site, luminescence originating from the sensor site propagates into the substrate, the second surface of the substrate being configured to selectively transmit the luminescence propagating within the substrates at angles greater than the critical angle out of the substrate where it may be detected by a detector (160) provided below the substrate.

Abstract: The present application provides a system (1) that comprises a mobile phone (25) to allow testing of samples from a patient at the point of care or environmental/industrial process monitoring tests to be performed in the field. The system (1) may be easily adapted for use with a variety of different mobile phones (25). The mobile phone (25) comprises an integrated camera (15). The system (1) further comprises an optical module (20) for receiving a sample for testing. The mobile phone (25) is configured to extract the intensity and/or color information from the camera (15).

Abstract: The invention includes Clostridial neurotoxin derivatives containing at least two light chain endopeptidase domains, and nucleic acids encoding such Clostridial neurotoxin derivatives. In preferred embodiments, the invention includes methods and compositions for the treatment of inflammatory disorders (such as arthritis); chronic pain, such as neuropathic pain and inflammatory pain through the use of such Clostridial neurotoxin derivatives, including those derived from an intact BoNT/A having an LC/E-derived endopeptidase joined to the LC/A endopeptidase.

Abstract: The present application relates to comb frequency generator devices generally and more particularly to the use of comb generators for use in fibre optic communications. More particularly, the application provides a frequency comb generator device. The device comprises a laser (30), a biasing circuit for providing a DC bias current (26), an RF circuit (22) providing a RF signal and a drive circuit (28) for combining the RF signal with the DC bias current to provide a drive current to the laser (30). With the DC bias current below threshold of the laser diode and RF bias with a frequence close to the relaxation ascillation frequency of the laser diode, a periodic pulse train is emitted with constant phase.

Abstract: A system for sensing and measuring ammonia in a breath sample is described. The system comprises a sampling means for capturing and directing a breath sample from a subject to an ammonia sensor, the ammonia sensor comprising a conducting polymer polyaniline sensor. The sampling means comprises a breath sample capture chamber, the chamber having an inlet and outlet, the inlet having a first valve through which a breath is exhaled into the sample capture chamber, the outlet having a second valve through which breath surplus to the volume of the chamber is expelled, to provide capture of a breath sample of predefined volume.