Patents Assigned to Duke University, Inc.
  • Patent number: 4510938
    Abstract: Means are provided for securing to the human body a light source housing and a light detector housing used for monitoring metabolism, said means comprising sockets adapted to fit over the housings and having tab members adapted to be adhesively secured to the body to maintain the respective light source and light detector housings in spaced relation on the body and further comprising a light-shielded pad fitted over said sockets and adhered to the body to provide light shielding for the light source and light detector confined in said housings.
    Type: Grant
    Filed: January 24, 1983
    Date of Patent: April 16, 1985
    Assignee: Duke University, Inc.
    Inventors: Frans F. Jobsis, Hans H. Keizer, Ronald F. Overaker
  • Patent number: 4380240
    Abstract: A mounting structure secures to a selected portion of the human body, e.g., the head, a limb, or the torso, and incorporates light source and light detecting means adapted for association with spectrophotometric circuitry for in situ, in vivo monitoring of local metabolism in the area of the body where the structure is secured.
    Type: Grant
    Filed: August 3, 1981
    Date of Patent: April 19, 1983
    Assignee: Duke University, Inc.
    Inventors: Frans F. Jobsis, Johannes H. Keizer, Ronald F. Overaker
  • Patent number: 4321930
    Abstract: A mounting structure secures to a selected portion of the human body, e.g., the head, a limb, or the torso, and incorporates light source and light detecting means adapted for association with spectrophotometric circuitry for in situ, in vivo monitoring of local metabolism in the area of the body where the structure is secured.
    Type: Grant
    Filed: September 18, 1980
    Date of Patent: March 30, 1982
    Assignee: Duke University, Inc.
    Inventors: Frans F. Jobsis, Johannes H. Keizer, Ronald F. Overaker
  • Patent number: 4281645
    Abstract: A spectrophotometric transillumination method and apparatus are directed to non-invasive, continuous, atraumatic, in vivo, in situ monitoring of metabolism in a body organ. In the described applications, measuring and reference wavelengths within the near infrared region, i.e., 700-1300 nm, are utilized for non-invasive, continuous, atraumatic, in situ, in vivo monitoring of oxidative metabolism by monitoring oxygen sufficiency in an internal organ, e.g., the brain or heart, of a human or animal body. Advantage is taken of the critical characteristic of cellular enzyme cytochrome a, a.sub.3 within the optical path and within the radiated portion of the selected organ for absorbing the selected measuring wavelength and for light of this measuring wavelength, as well as at least one reference wavelength within the same defined infrared region and at a low, non-hazardous level of intensity to travel through and be detectable at the end of a relatively long path, e.g.
    Type: Grant
    Filed: June 28, 1977
    Date of Patent: August 4, 1981
    Assignee: Duke University, Inc.
    Inventor: Frans F. Jobsis
  • Patent number: 4229426
    Abstract: This disclosure relates to assay of a glycoprotein component of human breast gross cystic disease fluid which has been designated GCDFP-15. This material is a useful marker in monitoring the efficacy of therapy in women with metastatic breast carcinoma and also in determining the maturity of the fetus in pregnant women. The assay for GCDFP-15 can also be used in conjunction with other assays for breast carcinoma such as an assay for carcinoembryonic antigen (CEA) whereby the utilization of both tests is more effective in monitoring for recurrence of disease than using either assay alone.
    Type: Grant
    Filed: February 22, 1978
    Date of Patent: October 21, 1980
    Assignee: Duke University, Inc.
    Inventor: Darrow E. Haagensen, Jr.
  • Patent number: 4223680
    Abstract: A spectrophotometric method, apparatus and reflectance technique is directed to non-invasive, harmless, continuous, atraumatic, in vivo, in situ monitoring of metabolism in a body organ utilizing measuring and reference wavelengths within the near infrared region, i.e., 700-1300 nm. Monitoring of oxidative metabolism is accomplished by monitoring oxygen sufficiency in an organ, normally an internal vital organ, e.g., the brain or heart, of a living human or animal body. Advantage is taken of the critical characteristic of cellular enzyme cytochrome a, a.sub.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: September 23, 1980
    Assignee: Duke University, Inc.
    Inventor: Frans F. Jobsis