Patents Assigned to Duke Unversity
  • Boronated compounds
    Patent number: 5362732
    Abstract: A novel class of pharmaceutically active boronated compounds are provided. The boronated compounds include boronated purine and pyrimidine bases and boronated nucleosides, as well as phosphate esters and oligomers thereof. The compounds are boronated at the ring nitrogen of the purine or pyrimidine base, or at a 2', 3' or 5' amino substituent of the nucleoside sugar.
    Type: Grant
    Filed: July 7, 1992
    Date of Patent: November 8, 1994
    Assignees: University of North Carolina at Chapel Hill, Boron Biologicals, Duke Unversity
    Inventors: Bernard F. Spielvogel, Anup Sood, Iris H. Hall, Barbara R. Shaw, Jeno Tomasz