Abstract: Methods of administering an active agent such as an active pharmaceutical ingredient by spraying a composition comprising the active agent at a luminal wall of the gastrointestinal tract are disclosed. Also disclosed are devices for administering a composition suitable for implementing the disclosed method. Also disclosed is the use of a peptide as an active agent for the manufacture of a sprayable composition for use in the treatment of a subject by gastrointestinal administration.

Abstract: A device useful for treatment of conditions relating to an eating disorder comprises: a) a duodenum obstructing component configured to partially obstruct the lumen of a duodenum in which deployed, preferably so as to reduce the rate of passage of materials through the duodenum; and b) an anchoring component configured to substantially maintain a position of the obstructing component inside a duodenum wherein deployed. The obstructing component does not block entry of food into the duodenum but rather causes a given volume of food that enters the duodenum to induce a greater degree of satiety and/or to induce a perception of satiety for a longer period of time and/or to induce a perception of satiety faster than otherwise.

Abstract: An apparatus and a method for treating a weight disorder in a subject are provided. The apparatus comprising an implantable device such as an inflatable balloon and electrodes capable of sensing a physiological change associated with food ingestion or hunger and a mechanism adapted for directly stimulating a region such as the duodenum which is responsive to a gastrointestinal satiety agent, such a mechanism can be a drug reservoir containing a drug such as CCK or analogs thereof which is contained within an inflatable balloon being implantable in a stomach of the subject. The apparatus and method provided here combine synergistic approaches to limiting meal size, i.e., chemo and mechano receptor activation of vagal satiety stimuli, electric stimulation of specific vagal pathways and limitations of gastric space.