Abstract: An in-situ gel ophthalmic drug delivery system for estrogen containing an estrogen, a solubilizing and complexing agent, a humectant, a sorbic acid or sorbic acid based stabilizer, an optional chelating agent and gellan gum in the amount of about 0.1-0.5% w/v, optionally 0.1-0.3% w/v, of the composition.
Type:
Grant
Filed:
September 28, 2010
Date of Patent:
March 25, 2014
Assignee:
Duquesne University of the Holy Spririt
Inventors:
Moji Christianah Adeyeye, Vicki L. Davis, Uday K. Kotreka