Patents Assigned to DVS Sciences Inc.
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Publication number: 20140120550Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.Type: ApplicationFiled: October 22, 2013Publication date: May 1, 2014Applicant: DVS SCIENCES INC.Inventor: VLADIMIR BARANOV
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Publication number: 20140121117Abstract: In a mass cytometer system, a tissue sample labeled with multiple metal tags is supported on an encoded substrate for distribution profile mapping by laser ablation. Groups of elemental ions from each plume generated by each laser pulse are detected by the mass cytometer and the data is mapped according to the encoded substrate. This configuration allows for the production of a 3-dimentional distribution profile of the multiple metal tags in the tissue sample.Type: ApplicationFiled: October 22, 2013Publication date: May 1, 2014Applicant: DVS SCIENCES INC.Inventor: SCOTT TANNER
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Publication number: 20130268211Abstract: An apparatus for elemental analysis of particles such as single cells or single beads by mass spectrometry is described. The apparatus includes means for particle introduction; means to vaporize, atomize and ionize elements associated with a particle; means to separate the ions according to their mass-to-charge ratio; means to detect the separated ions, means to digitize the output of the means to detect the ions; means to transfer and/or to process and/or record the data output of the means to digitize, having means to detect the presence of a particle in a mass spectrometer; and means to synchronize one of the means for ion detection, data digitization, transfer, processing and recording with the means to detect the presence of a particle. Methods and computer readable code implementing aspects of the apparatus, and for reducing the rates of data generation, digitization, transfer, processing and recording are also described.Type: ApplicationFiled: May 22, 2013Publication date: October 10, 2013Applicant: DVS Sciences, Inc.Inventors: Alexei Antonov, Dmitry Roman Bandura
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Publication number: 20130181126Abstract: In a mass cytometer or mass spectrometer, a sample of elemental tagged particles is transferred from a dispersion to a gas flow through a carrier aerosol spray for atomization and ionization by inductively coupled plasma (ICP) source. The configuration of the sample transfer apparatus allow for total consumption of the sample by passing the sample spray through a deceleration stage to decelerate the spray of particles from its high velocity expansion. Following the deceleration stage, the decelerated sample of particles can be accelerated and focused through an acceleration stage for transferring into the ICP. This effectively improves the particle transfer between the sample spray and the ICP.Type: ApplicationFiled: October 26, 2012Publication date: July 18, 2013Applicant: DVS SCIENCES INC.Inventor: DVS Sciences Inc.
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Patent number: 8481925Abstract: An apparatus for elemental analysis of particles such as single cells or single beads by mass spectrometry is described. The apparatus includes means for particle introduction; means to vaporize, atomize and ionize elements associated with a particle; means to separate the ions according to their mass-to-charge ratio; means to detect the separated ions, means to digitize the output of the means to detect the ions; means to transfer and/or to process and/or record the data output of the means to digitize, having means to detect the presence of a particle in a mass spectrometer; and means to synchronize one of the means for ion detection, data digitization, transfer, processing and recording with the means to detect the presence of a particle. Methods and computer readable code implementing aspects of the apparatus, and for reducing the rates of data generation, digitization, transfer, processing and recording are also described.Type: GrantFiled: June 24, 2011Date of Patent: July 9, 2013Assignee: DVS Sciences Inc.Inventors: Alexei Antonov, Dmitry Roman Bandura
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Publication number: 20130078644Abstract: Methods and kits for enzymes involved in post-translational modifications are provided. The methods employ elemental analysis, including ICP-MS.Type: ApplicationFiled: November 21, 2012Publication date: March 28, 2013Applicant: DVS SCIENCES, INC.Inventor: DVS SCIENCES, INC.
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Publication number: 20120264118Abstract: Methods and kits for the quantitation of cellular DNA and cell numbers are provided. Passive element uptake, element-labeled DNA intercalators, and element labeled affinity reagents are used to quantify DNA and cells. The DNA and the cells are analyzed by elemental analysis, including ICP-MS. The methods and kits provide a fast and accurate analysis of cellular DNA and cell numbers.Type: ApplicationFiled: June 29, 2012Publication date: October 18, 2012Applicant: DVS SCIENCES, INC.Inventors: Olga Ornatsky, Vladimir Baranov
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Patent number: 8283624Abstract: An apparatus for elemental analysis of particles such as single cells or single beads by mass spectrometry is described. The apparatus includes means for particle introduction; means to vaporize, atomize and ionize elements associated with a particle; means to separate the ions according to their mass-to-charge ratio; means to detect the separated ions, means to digitize the output of the means to detect the ions; means to transfer and/or to process and/or record the data output of the means to digitize, having means to detect the presence of a particle in a mass spectrometer; and means to synchronize one of the means for ion detection, data digitization, transfer, processing and recording with the means to detect the presence of a particle. Methods and computer readable code implementing aspects of the apparatus, and for reducing the rates of data generation, digitization, transfer, processing and recording are also described.Type: GrantFiled: August 14, 2007Date of Patent: October 9, 2012Assignee: DVS Sciences Inc.Inventors: Alexei Antonov, Dmitry Roman Bandura
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Publication number: 20120208210Abstract: Methods and kits for enzymes involved in post-translational modifications are provided. The methods employ elemental analysis, including ICP-MS.Type: ApplicationFiled: December 7, 2011Publication date: August 16, 2012Applicant: DVS SCIENCES INC.Inventor: Olga Ornatsky
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Patent number: 8236511Abstract: Methods and kits for the quantitation of cellular DNA and cell numbers are provided. Passive element uptake, element-labeled DNA intercalators, and element labeled affinity reagents are used to quantify DNA and cells. The DNA and the cells are analyzed by elemental analysis, including ICP-MS. The methods and kits provide a fast and accurate analysis of cellular DNA and cell numbers.Type: GrantFiled: December 21, 2011Date of Patent: August 7, 2012Assignee: DVS Sciences, Inc.Inventors: Olga Ornatsky, Vladimir Baranov
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Publication number: 20120164632Abstract: Methods and kits for the quantitation of cellular DNA and cell numbers are provided. Passive element uptake, element-labeled DNA intercalators, and element labeled affinity reagents are used to quantify DNA and cells. The DNA and the cells are analyzed by elemental analysis, including ICP-MS. The methods and kits provide a fast and accurate analysis of cellular DNA and cell numbers.Type: ApplicationFiled: December 21, 2011Publication date: June 28, 2012Applicant: DVS SCIENCES, INC.Inventors: Olga Ornatsky, Vladimir Baranov
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Publication number: 20120061561Abstract: An apparatus for elemental analysis of particles such as single cells or single beads by mass spectrometry is described. The apparatus includes means for particle introduction; means to vaporize, atomize and ionize elements associated with a particle; means to separate the ions according to their mass-to-charge ratio; means to detect the separated ions, means to digitize the output of the means to detect the ions; means to transfer and/or to process and/or record the data output of the means to digitize, having means to detect the presence of a particle in a mass spectrometer; and means to synchronize one of the means for ion detection, data digitization, transfer, processing and recording with the means to detect the presence of a particle. Methods and computer readable code implementing aspects of the apparatus, and for reducing the rates of data generation, digitization, transfer, processing and recording are also described.Type: ApplicationFiled: June 24, 2011Publication date: March 15, 2012Applicant: DVS SCIENCES INC.Inventors: Alexei Antonov, Dmitry Roman Bandura
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Patent number: 8101368Abstract: Methods and kits for the quantitation of cellular DNA and cell numbers are provided. Passive element uptake, element-labeled DNA intercalators, and element labeled affinity reagents are used to quantify DNA and cells. The DNA and the cells are analyzed by elemental analysis, including ICP-MS. The methods and kits provide a fast and accurate analysis of cellular DNA and cell numbers.Type: GrantFiled: February 13, 2007Date of Patent: January 24, 2012Assignee: DVS Sciences Inc.Inventors: Olga Ornatsky, Vladimir Baranov
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Patent number: 8093014Abstract: Kits for the assay of enzymes involved in post-translational modifications are provided. The kits facilitate the execution of methods of assay that allow for convenient and accurate analysis using atomic mass spectrometry of post-translation modifications of substrates by enzymes involved in post-translational modifications, including kinase and phosphatase enzymes.Type: GrantFiled: February 13, 2007Date of Patent: January 10, 2012Assignee: DVS Sciences Inc.Inventor: Olga Ornatsky