Abstract: A chemohyperthermia treatment system includes a reservoir for storing fluid, a heating/cooling system coupled to the reservoir so that the fluid can be transferred from the reservoir to the heating system, wherein the heating/cooling system comprises a heating/cooling exchange module having a channel within which the fluid can flow, and a plurality of peltier modules/heating strips coupled to the heating/cooling module, wherein the plurality of peltier modules/heating strips heat up the fluid flowing through the channel, and wherein in the cooling mode, the plurality of peltier modules cool the fluid flowing through the channel. A pumping means is coupled to the heating/cooling system, wherein the pumping means pump the perfusion fluid from the reservoir to the heating/cooling system, thereby allowing the heating/cooling system to change the temperature of the fluid.