Patents Assigned to Dyax Corp.
  • Publication number: 20150023978
    Abstract: The present invention relates to monoclonal antibodies and antigen-binding portions thereof that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The invention also relates to isolated heavy and light chain immunoglobulins derived from anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.
    Type: Application
    Filed: January 17, 2014
    Publication date: January 22, 2015
    Applicants: Baxter International Inc., Dyax Corp., Baxter Healthcare SA
    Inventors: Randolf Kerschbaumer, Friedrich Scheiflinger, Manfred Rieger, Michael Thiele, Geert C. Mudde, Juergen Muellberg, Rene Hoet
  • Patent number: 8901045
    Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods are disclose. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens are also disclosed.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: December 2, 2014
    Assignee: Dyax Corp.
    Inventors: Robert C. Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet, Hendricus Renerus Jacobus Mattheus Hoogenboom
  • Publication number: 20140335023
    Abstract: Plasma kallikrein binding proteins and methods of using such proteins are described.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 13, 2014
    Applicant: Dyax Corp.
    Inventors: Daniel J. Sexton, Malini Viswanathan
  • Publication number: 20140335082
    Abstract: Proteins that bind to matrix metalloproteinase 14, combination therapies with such proteins and methods of using such proteins are described.
    Type: Application
    Filed: October 18, 2012
    Publication date: November 13, 2014
    Applicant: DYAX CORP.
    Inventor: Daniel T. Dransfield
  • Publication number: 20140308206
    Abstract: The disclosure relates to antibodies that bind FcRn and methods of using these antibodies.
    Type: Application
    Filed: June 1, 2012
    Publication date: October 16, 2014
    Applicant: DYAX CORP.
    Inventors: Daniel J. Sexton, Christopher Tenhoor, Malini Viswanathan
  • Publication number: 20140302048
    Abstract: Plasma kallikrein binding proteins and methods of using such proteins are described.
    Type: Application
    Filed: June 20, 2014
    Publication date: October 9, 2014
    Applicant: Dyax Corp.
    Inventors: Daniel J. Sexton, Malini Viswanathan
  • Publication number: 20140286864
    Abstract: The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD<1 ?M), and dimer and multimeric constructs comprising these polypeptides.
    Type: Application
    Filed: December 17, 2013
    Publication date: September 25, 2014
    Applicants: Bracco Suisse SA, Dyax Corp.
    Inventors: AARON K. SATO, DANIEL J. SEXTON, DANIEL T. DRANSFIELD, ROBERT CHARLES LADNER, CHRISTOPHE ARBOGAST, PHILIPPE BUSSAT, HONG FAN, SUDHA KHURANA, KAREN E. LINDER, EDMUND R. MARINELLI, PALANIAPPA NANJAPPAN, ADRIAN D. NUNN, RADHAKRISHNA K. PILLAI, SIBYLLE POCHON, KONDAREDDIAR RAMALINGAM, AJAY SHRIVASTAVA, BO SONG, ROLF E. SWENSON, MATHEW A. VON WRONSKI, FENG YAN
  • Publication number: 20140288001
    Abstract: Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.
    Type: Application
    Filed: May 6, 2014
    Publication date: September 25, 2014
    Applicant: DYAX CORP.
    Inventors: Henry Blair, Thomas Beck, Robert Charles Ladner
  • Patent number: 8828703
    Abstract: Proteins including engineered sequences which inhibit proteases are disclosed, including proteins having two or more engineered Kunitz domains, and uses of such proteins.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: September 9, 2014
    Assignee: Dyax Corp.
    Inventor: Robert C. Ladner
  • Publication number: 20140248287
    Abstract: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
    Type: Application
    Filed: January 30, 2014
    Publication date: September 4, 2014
    Applicants: SYNTONIX PHARMACEUTICALS, INC., DYAX CORP.
    Inventors: Christopher TenHoor, Arumugam Muruganandam, Robert Charles Ladner, Clive Wood, Alan J. Bitonti, James Stattel, Kevin McDonnell, Liming Liu, Jennifer Dumont, Aaron K. Sato, Malini Viswanathan
  • Patent number: 8822653
    Abstract: Plasma kallikrein binding proteins and methods of using such proteins are described.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: September 2, 2014
    Assignee: Dyax Corp.
    Inventors: Daniel J. Sexton, Malini Viswanathan
  • Patent number: 8816055
    Abstract: Plasma kallikrein binding proteins and methods of using such proteins are described.
    Type: Grant
    Filed: January 6, 2012
    Date of Patent: August 26, 2014
    Assignee: Dyax Corp.
    Inventors: Daniel J. Sexton, Malini Viswanathan
  • Patent number: 8815246
    Abstract: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: August 26, 2014
    Assignees: Dyax Corp., Syntonix Pharmaceuticals, Inc.
    Inventors: Christopher TenHoor, Arumugam Muruganandam, Robert Charles Ladner, Clive Wood, Alan J. Bitonti, James Stattel, Kevin McDonnell, Liming Liu, Jennifer Dumont, Aaron K. Sato, Malini Viswanathan
  • Publication number: 20140221611
    Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.
    Type: Application
    Filed: August 14, 2013
    Publication date: August 7, 2014
    Applicant: DYAX CORP.
    Inventors: Jinan Yu, M. Daniel Potter, Brian D. Kelley, Jeffrey S. Deetz, James E. Booth
  • Publication number: 20140205545
    Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.
    Type: Application
    Filed: September 19, 2013
    Publication date: July 24, 2014
    Applicants: Dyax Corp., Bracco Suisse S.A.
    Inventors: Hong FAN, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Radhakrishna K. Pillai, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski, Aaron K. Sato, Sharon Michele Walker, Daniel T. Dransfield
  • Publication number: 20140200165
    Abstract: The present invention provides Fab libraries and methods for using the Fab libraries to obtain antibodies against a target. The Fab library of the invention contains at least 109 different Fabs, and in some embodiments, at least 1010 different Fabs. The Fab libraries of the invention are used to isolate polyclonal or monoclonal Fabs that bind with high specificity to targets.
    Type: Application
    Filed: November 26, 2013
    Publication date: July 17, 2014
    Applicant: Dyax Corp.
    Inventor: Hendricus Renerus Jacobus Mattheus Hoogenboom
  • Publication number: 20140193413
    Abstract: The present disclosure relates to an antibody or antibody fragment capable of binding to phosphorylcholine and/or a phosphorylcholine conjugate, wherein the antibody or antibody fragment comprises a variable heavy chain (VH) domain and/or a variable light chain (VL) domain, and wherein (a) the VH domain comprises complementarity determining regions (CDRs) selected from the group consisting of: a CDR1 sequence having identity to the sequence of SEQ ID NO: 7; a CDR2 sequence having identity to the sequence of SEQ ID NO: 8; and a CDR3 sequence having identity to the sequence of SEQ ID NO: 9 or 10; and/or (b) the VL domain comprises CDRs selected from the group consisting of: a CDR4 sequence having identity to the sequence of SEQ ID NO: 11; a CDR5 sequence having identity to the sequence of SEQ ID NO: 12; a CDR6 sequence having identity to the sequence of SEQ ID NO: 13.
    Type: Application
    Filed: August 8, 2012
    Publication date: July 10, 2014
    Applicants: DYAX CORP., ATHERA BIOTECHNOLOGIES AB
    Inventors: Knut Pettersson, Ola Camber, Dan Sexton, Andrew E. Nixon
  • Publication number: 20140178410
    Abstract: The present invention relates to an antibody or antibody fragment capable of binding to phosphorylcholine and/or a phosphorylcholine conjugate, wherein the antibody or antibody fragment comprises a variable heavy chain (VH) domain and/or a variable light chain (VL) domain, and wherein—(a) the VH domain comprises an amino acid sequence that includes one, two or three complementarity determining regions (CDRs) selected from the group consisting of: a CDR1 sequence comprising an amino acid sequence having at least 25%, 50%, 75% or 100% sequence identity to the sequence of SEQ ID NO: 17; a CDR2 sequence comprising an amino acid sequence having at least 5%, 11%, 17%, 23%, 29%, 35%, 47%, 52%, 58%, 64%, 70%, 76%, 82%, 94% or 100% sequence identity to the sequence of SEQ ID NO: 18; and a CDR3 sequence comprising an amino acid sequence having at least 4%, 9%, 13%, 18%, 22%, 27%, 31%, 36%, 40%, 45%, 50%, 54%, 59%, 63%, 68%, 72%, 77%, 81%, 86%, 90%, 95% or 100% sequence identity to the sequence of SEQ ID NO: 19, 20, 21
    Type: Application
    Filed: August 8, 2012
    Publication date: June 26, 2014
    Applicants: DYAX CORP., ATHERA BIOTECHNOLOGIES AB
    Inventors: Knut Pettersson, Ola Camber, Dan Sexton, Andrew E. Nixon
  • Patent number: 8748368
    Abstract: The invention relates to a method for preserving an organ or tissue comprising contacting the organ or tissue with an effective amount of a kallikrein inhibitor and solutions useful for such a method. Also provided is a method for reducing reperfusion injury of an organ during surgery and/or following removal of the organ from a subject comprising placing the organ in an organ storage and preservative solution, wherein the solution comprises a kallikrein inhibitor.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: June 10, 2014
    Assignee: DYAX Corp.
    Inventors: Marco Cicardi, Luigi Bergamaschini
  • Publication number: 20140135226
    Abstract: Disclosed are methods for identifying desired members from a display libraries, including bacteriophage display libraries. Display library members can be amplified in the presence of a target compound so that cycles of selection can be rapidly completed.
    Type: Application
    Filed: October 8, 2013
    Publication date: May 15, 2014
    Applicant: Dyax Corp.
    Inventors: Robert Charles Ladner, Shannon Hogan, Kristin L. Rookey