Patents Assigned to Dynal AS
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Patent number: 9199247Abstract: The disclosure relates to a magnetic separation rack for isolating magnetically labeled particles from a non-magnetic medium comprising a body portion (1) and a foot portion (8). The body portion comprises an array of sample vessel retaining portions (2) and plurality of magnetizing portions (3). Each sample vessel retaining portion comprises at least one visible portion such that when a sample vessel is mounted in a sample vessel retaining portion at least one portion of the sample vessel is visible to a user. The magnetizing portions are arranged within the body portion (1) such that at least two magnetizing portions (3) are circumferentially spaced about each sample vessel retaining portion (2). The foot portion is pivotally coupled to the body portion such that the body portion is operatively tiltable with respect to the foot portion such that each sample vessel retaining portion may retain a sample vessel mounted therein in a tilted position with respect to the vertical.Type: GrantFiled: May 29, 2008Date of Patent: December 1, 2015Assignee: Invitrogen Dynal ASInventors: Darren Ellis, Tine Borgen Hildisch, Jeremy Mundy, Erlend Ragnhildstveit, Richard Johan Toften, Kornelija Zgonc
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Publication number: 20150329617Abstract: Novel compounds carrying ligands capable of ligating to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as in various methods. In particular, novel MHC molecule constructs comprising one or more MHC molecules are disclosed. The affinity and avidity of the MHC molecules of the constructs are surprisingly high. The possibility of presenting to the target cells a plurality of MHC molecules makes the MHC molecule constructs an extremely powerful tool e.g. in the field of diagnosis. The invention relates in general to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC molecules, MHC molecule multimers, and MHC molecule constructs.Type: ApplicationFiled: March 13, 2002Publication date: November 19, 2015Applicants: DYNAL BIOTECH ASA, DAKO A/SInventors: Lars Winther, Lars Oestergaard Petersen, Soeren Buus, Joergen Schoeller, Erik Ruud, Oeystein Aamellem
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Patent number: 8263324Abstract: The present invention relates to a method of isolating nucleic acid from a blood sample, said method comprising: (a) selectively isolating leucocytes from said sample by binding said leucocytes to a solid support by means of a binding partner specific for leucocytes; (b) lysing said isolated leucocytes; and (c) binding nucleic acid released from said lysed cells to said solid support. Kits for isolating nucleic acid from samples form further embodiments of the invention.Type: GrantFiled: April 4, 2008Date of Patent: September 11, 2012Assignee: Invitrogen Dynal ASInventors: Jack Andreassen, Lars Korsnes, Stine Bergholtz
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Patent number: 8227262Abstract: A process for the preparation of coated polymer particles containing superparamagnetic crystals, said process comprising reacting surface-functionalized, superparamagnetic crystal-containing polymer particles of diameter less than 0.5 ?m with at least one polyisocyanate and at least one diol.Type: GrantFiled: April 16, 2009Date of Patent: July 24, 2012Assignee: Invitrogen Dynal ASInventors: Geir Fonnum, Lars Kilaas, Arvid Trygve Berge, Tom-Nils Nilsen, Ruth Schmid, Grete Irene Modahl
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Publication number: 20120178090Abstract: The present invention comprises a method of isolating nucleic acid and protein from the same sample with solid supports, wherein nucleic acid and protein components contained in the sample become bound to distinct solid supports. The invention also allows for kits for isolating nucleic acid and protein from the same sample and for use of the method of isolating nucleic acid and protein for the analysis and/or comparison of mRNA and/or protein expression and/or their correlation to genomic information.Type: ApplicationFiled: January 4, 2012Publication date: July 12, 2012Applicant: INVITROGEN DYNAL ASInventor: Marie BOSNES
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Publication number: 20120141798Abstract: This invention relates to monodisperse cross-linked polymer particles, comprising particles with a substantially smooth outer surface and an average diameter of less than 1 ?m, wherein the particles are solid or porous, and wherein the coefficient of variation (CV) % of the particles, when measured by CPS disk centrifugation analysis, is less than 15%. These monodisperse cross-linked polymer particles may comprise magnetic material and are useful in various application. This invention also relates to monodisperse polymer particles for use as seed particles in the Ugelstad process.Type: ApplicationFiled: April 29, 2010Publication date: June 7, 2012Applicant: INVITROGEN DYNAL ASInventors: Grete Irene Modahl, Geir Fonnum, Astrid Molteberg, Silje Lien, Nini Kjus
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Patent number: 8110351Abstract: The present invention comprises a method of isolating nucleic acid and protein from the same sample with solid supports, wherein nucleic acid and protein components contained in the sample become bound to distinct solid supports. The invention also allows for kits for isolating nucleic acid and protein from the same sample and for use of the method of isolating nucleic acid and protein for the analysis and/or comparison of mRNA and/or protein expression and/or their correlation to genomic information.Type: GrantFiled: January 16, 2003Date of Patent: February 7, 2012Assignee: Invitrogen Dynal ASInventor: Marie Bosnes
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Patent number: 8038987Abstract: A process for the preparation of coated polymer particles containing superparamagnetic crystals, said process comprising reacting porous, surface-functionalized, superparamagnetic crystal-containing polymer particles of diameter 0.5 to 1.8 ?m with at least one polyisocyanate and at least one diol or at least one epoxide.Type: GrantFiled: November 27, 2006Date of Patent: October 18, 2011Assignee: Invitrogen Dynal ASInventors: Geir Fonnum, Nini Kjus Hofsløkken, Elin Marie Aksnes, Lars Kilaas, Arvid Trygve Berge, Per Stenstad, Ruth Schmid, Jon Olav Bjorgum, Tom-Nils Nilsen
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Publication number: 20110198293Abstract: The disclosure relates to a magnetic separating device for isolating magnetically labelled particles from a non-magnetic medium comprising a body portion (1) having a magnetising portion (3) for providing a magnetic field and a surface by means of which the body portion may stand on a supporting surface; and a sample vessel retaining portion (4) for retaining at least one sample vessel (5), wherein, the magnetising portion (3) is configured to conform at least approximately to at least a substantial portion of the longitudinal profile of at least one sample vessel (5); the sample vessel retaining portion (4) is configured to retain at least one sample vessel (5) such that at least a portion of the contents of the sample vessel (5) is visible to a user; and the sample vessel retaining portion (4) is configured to be mountable on the magnetising portion so that in use, the at least one sample vessel is subject to the magnetic field of the magnetising portion (3).Type: ApplicationFiled: May 29, 2008Publication date: August 18, 2011Applicant: INVITROGEN DYNAL ASInventors: Darren Ellis, Tine Borgen Hildisch, Jeremy Mundy, Erlend Ragnhildstveit, Richard Johan Toften, Kornelija Zgonc, Gaute Brede, Lars Nokleby
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Patent number: 7989614Abstract: The present invention provides a method of isolating nucleic acid from a sample, said method comprising contacting said sample with a detergent and a solid support, whereby soluble nucleic acid in said sample is bound to the support, and separating said support with bound nucleic acid from the sample. Where the method of the invention is used to isolate DNA, it may conveniently be couple with a further step to isolate RNA from the same sample.Type: GrantFiled: March 24, 2008Date of Patent: August 2, 2011Assignee: Invitrogen Dynal ASInventors: Arne Deggerdal, Frank Larsen
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Patent number: 7985340Abstract: A magnetic separator unit for the selective separation of at least one component from a fluid mixture is described. The unit can include at least one mandrel-shaped magnet unit and tubing wrapped around it. Fluid containing magnetisable particles can be passed through the tubing to allow attraction of the particles to the magnet unit.Type: GrantFiled: December 1, 2006Date of Patent: July 26, 2011Assignee: Invitrogen Dynal ASInventors: Hilde Kjersti Almaasbak, Christer Johansson
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Publication number: 20100301257Abstract: This invention relates to monodisperse cross-linked polymer particles, comprising particles with a substantially smooth outer surface and an average diameter of less than 1 ?m, wherein the particles are solid or porous, and wherein the coefficient of variation (CV) % of the particles, when measured by CPS disk centrifugation analysis, is less than 15%. These monodisperse cross-linked polymer particles may comprise magnetic material and are useful in various application. This invention also relates to monodisperse polymer particles for use as seed particles in the Ugelstad process.Type: ApplicationFiled: April 29, 2010Publication date: December 2, 2010Applicant: Invitrogen Dynal ASInventors: Grete Irene Modahl, Geir Fonnum, Astrid Molteberg, Silje Lien, Nini Hofslokken Kjus
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Publication number: 20100207051Abstract: Monodisperse polymer microparticles comprising polystyrene or polyacrylate, wherein said particles have a coating formed of at least one transition metal oxide or porous polymer microparticles comprising polystyrene or polyacrylate, wherein said particles have a coating formed of at least one transition metal oxide.Type: ApplicationFiled: December 19, 2007Publication date: August 19, 2010Applicants: INVITROGEN DYNAL AS, University of Southern DenmarkInventors: Geir Fonnum, Torkel Stene, Nini Hofsloekken Kjus, Stine Louise Bergholtz, Kasper Engholm-Keller, Finn Kirpekar, Martin Larsen, Robert Marshall Pope, Olen N. Jensen, Liang Xiquan
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Patent number: 7763689Abstract: A process for the preparation of amine-functionalized vinyl polymer particles which process comprises suspension polymerizing minostyrene together with at least one other vinylic monomer and optionally a crosslinking agent.Type: GrantFiled: August 21, 2007Date of Patent: July 27, 2010Assignee: Dynal Biotech ASAInventors: Geir Fonnum, Ellen Weng, Elin Marie Aksnes, Rolf Nordal, Preben Cato Mørk, Svein Tøgersen, Julian Cockbain
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Publication number: 20100068193Abstract: Methods are disclosed for the generation of immunosuppressive regulatory T cells. The methods can include contacting a population of CD4+CD25? T cells with a T cell receptor (TCR)/CD3 activator, a TCR co-stimulator activator, and rapamycin. Kits for the generation of immunosuppressive regulatory T cells, methods of use, and cell populations are also disclosed.Type: ApplicationFiled: February 15, 2007Publication date: March 18, 2010Applicant: INVITROGEN DYNAL ASInventors: Anne Brunsvig, Anne-Marie Rasmussen, Borelli Piedras, Gunnar Kvalheim, Tanja Aarvak
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Publication number: 20100006509Abstract: A magnetic separation device (1) is provided for separating magnetic particles (15) from a liquid (14) in which they are suspended. The magnetic particles will generally have a target substance bonded thereto. The magnetic separation device comprises a chamber (4) having an opening therein. A nozzle (6) may be formed on the chamber with the opening being disposed in the end of the nozzle. The device is arranged to draw liquid into the chamber and expel liquid from the chamber through the opening, by means of, for example, a piston (2) or a vacuum line. The chamber contains a means (8) for separating magnetic particles suspended in the liquid from the liquid, said means comprising a magnetisable element. The magnetisable element may be, for example, a matrix of magnetic spheres. A magnetic separation apparatus (18) comprises a plurality of such magnetic separation devices, and may be automatically operated by an electronic means.Type: ApplicationFiled: April 25, 2006Publication date: January 14, 2010Applicant: Invitrogen Dynal ASInventor: Erik Hornes
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Publication number: 20090069554Abstract: The present invention provides a method of isolating nucleic acid from a sample, said method comprising contacting said sample with a solid support, preferably magnetic beads, in the presence of an ethylene glycol multimer consisting of from 2 to 70 ethylene oxide monomers, preferably tetraethylene glycol, whereby soluble nucleic acid in said sample is bound to the surface of the support, and separating said support with bound nucleic acid from the sample. Kits for performance of the invention are also provided.Type: ApplicationFiled: February 13, 2006Publication date: March 12, 2009Applicant: Dynal Invitrogen ASInventor: Erling Finne
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Patent number: D637709Type: GrantFiled: March 12, 2008Date of Patent: May 10, 2011Assignee: Invitrogen Dynal ASInventors: Gaute Brede, Darren Ellis, Tine Borgen Hildisch, Jez Mundy, Lars Nokleby, Erlend Ragnhildstveit, Richard Johan Toften, Kornelija Zgonc
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Patent number: D638953Type: GrantFiled: November 12, 2009Date of Patent: May 31, 2011Assignee: Invitrogen Dynal ASInventors: Gil Cavada, Morten Egeberg, Jamie Hogan, Espir Kahatt, Lars Nøkleby, Lars Norderhaug, Tommy Rivrud, Kornelija Zgonc
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Patent number: D743533Type: GrantFiled: March 25, 2011Date of Patent: November 17, 2015Assignee: Invitrogen Dynal ASInventors: Gaute Brede, Darren Ellis, Tine Hildisch, Jez Mundy, Lars Nokleby, Erlend Ragnhildstveit, Richard Toften, Kornelija Zgonc