Abstract: Systems and methods for screening a subject for a therapy are described. A mechanical stimulation device positioned near at target location of a blood vessel to provide a mechanical stimulus to the blood vessel. The mechanical stimulus increases strain in one or more regions of the blood vessel, such as by modifying the cross-sectional geometry and/or area of the blood vessel to have different regions of different curvature A baroreflex or related physiological response in response to the mechanical stimulation is detected. In response to the detected response, it is determined whether the subject is appropriate for the therapy and/or which of a plurality of implants with different geometries and/or cross-sectional areas is most optimally suited for deployment in the subject.

Abstract: A particle growth apparatus includes a temperature-controlled humidifier coupled to a water-based condensation growth system. The humidifier may include a tube of sulfonated tetrafluoroethylene-based fluoropolymer-copolymer and surrounded by a region containing water or water vapor. The apparatus includes a wetted wick and wick sensor in the condensation growth system, configured such that the gas sample flows through the sulfonated tetrafluoroethylene-based fluoropolymer-copolymer tube into the condensation growth system.

Abstract: This specification discloses an article of manufacture. The article of manufacture has at least one structural blank and at least one guide. The structural blank has a plurality of oriented fiber plies in a thermoplastic matrix. The guide has a plurality of random dispersed fibers in a thermoplastic matrix. The guide is affixed to the structural blank by injection molding and over molding the guide onto the structural blank. The article of manufacture can take a number of forms for use in industries such as aircraft, automobiles, motorcycles, bicycles, trains or watercraft.

Abstract: Provided herein are methods for the production of antigen-specific effector T cells and NK cells from pluripotent stem cells which express a chimeric antigen receptor (CAR). Further provided herein are methods for the adoptive cell therapy by administering the effector T cells and/or NK cells provided herein.

Abstract: A lift-driven wind turbine has a turbine rotor with blades mounted to the turbine shaft by two struts hinged to the shaft and each blade to form a four-bar linkage. The blades' airfoil cross section generates lift that rotates the blades around the axis in the presence of a prevailing wind. The airfoil chord forms a geometric angle of attack ?G relative to the tangent of the blade path and the struts orient the blades with an outward tilt angle ?. The turbine is designed with values of ?G and ? that cause the lift generated by each blade to have an upward component that supports the blade against the force of gravity and a mean radially inward component that substantially balances centrifugal forces on the blade. Wind turbines designed according to the principles disclosed herein facilitate the construction of free-floating utility scale wind turbines for deep water installations.

Abstract: A method for terrain and constraint planning a step plan includes receiving, at data processing hardware of a robot, image data of an environment about the robot from at least one image sensor. The robot includes a body and legs. The method also includes generating, by the data processing hardware, a body-obstacle map, a ground height map, and a step-obstacle map based on the image data and generating, by the data processing hardware, a body path for movement of the body of the robot while maneuvering in the environment based on the body-obstacle map. The method also includes generating, by the data processing hardware, a step path for the legs of the robot while maneuvering in the environment based on the body path, the body-obstacle map, the ground height map, and the step-obstacle map.

Abstract: A robot includes a drive system configured to maneuver the robot about an environment and data processing hardware in communication with memory hardware and the drive system. The memory hardware stores instructions that when executed on the data processing hardware cause the data processing hardware to perform operations. The operations include receiving image data of the robot maneuvering in the environment and executing at least one waypoint heuristic. The at least one waypoint heuristic is configured to trigger a waypoint placement on a waypoint map. In response to the at least one waypoint heuristic triggering the waypoint placement, the operations include recording a waypoint on the waypoint map where the waypoint is associated with at least one waypoint edge and includes sensor data obtained by the robot. The at least one waypoint edge includes a pose transform expressing how to move between two waypoints.

Abstract: A wick liquid sensor suitable for use in a particle condensation device is provided. The sensor includes a light source configured to illuminate a surface of the wick. A detector is configured to detect wick reflected light from the light source and determine the intensity of reflected light. The wick is formed from a porous media that is wettable by the liquid, and becomes translucent when filled with the liquid. The amount of reflectivity decreases as the saturation content of the liquid in the wick increases.

Abstract: Disclosed is a fracture fixation plate assembly comprised of a body, a hinge, a pin, and one or more heads, in which the head or heads can pivot and displace laterally/medially and can tilt vertically with respect to the body of the plate, more efficiently and flexibly enabling the fastening of the body of the plate to a stable part of the bone prior to reduction of the fractured portion or portions of the bone.

Abstract: A system for inspection of electrical circuits, which electrical circuits include a multiplicity of conductors which are mutually spaced from each other, the system including a voltage driver operative to apply different electrical voltages to a plurality of conductors from among the multiplicity of conductors, which plurality of conductors are in spatial propinquity to each other, a sensor operative to sense at least one characteristic of a test region defined thereby with respect to the electrical circuits, the sensor lacking sufficient spatial resolution to distinguish between the locations of individual ones of the plurality of conductors and a defect indicator responsive to at least one output of the sensor for ascertaining whether a defect exists in the plurality of conductors.

Abstract: Embodiments of the present invention may provide a limb motion sensor system (100) used to objectively assist detection of equine lameness and even monitor change in gait quality over time. Biosensors (102) may be attached to the pair of front and/or hind limbs. Each conformally shaped biosensor device may be placed lateral to the metacarpal/metatarsal bone (e.g., attached to the lower limb). Inertial data may be collected by the set of sensor devices and may be wirelessly transferred to a portable, perhaps wearable, mobile controller and analytics unit (104) (e.g., smart phone, tablet, or the like). A signal processor application (108) may automatically segment each stride into phases and perform analyses to quantify limb motion metrics and uniformity over time for a single limb (unilateral consistency) or between the contralateral limbs (bilateral symmetry). Three-dimensional motion metrics may be processed, displayed, stored on, and even transmitted from the mobile information system.

Abstract: An example method includes identifying an operating state at which a velocity of a hydraulic actuator configured to operate a movable member of a robot is less than a threshold velocity and an actuator force is less than a threshold force, determining a valve command that corresponds to the operating state, such that the valve command is provided to a valve configured to control flow to and from the hydraulic actuator, and the valve includes a spool movable within a body of the valve, and the valve command causes the spool to move within the body of the valve to a position that induces the operating state, and determining a null bias signal based on the valve command.

Abstract: A plate for fracture fixation, a system and methods are provided including a plurality of individually adjustable heads and various features and accessories to achieve: a.) superior fixation of the plate to osteoporotic diaphyseal bone; b.) improved visualization of the fracture line; c.) intraoperative adjustability to achieve better contact of the plate and the bone; d.) reduced risk of post-surgery tendon rupture; d.) improved fixation of small volar marginal fragments; e.) improved targeting and fixing of particular fractured bone fragments and, f.) reduced surgical operation time.

Abstract: Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided.

Abstract: A wind-driven power generating system with a hybrid wind turbine mounted on a floating platform that heels relative to horizontal in the presence of a prevailing wind. The hybrid turbine has a turbine rotor with at least two rotor blades, each mounted to a turbine shaft by at least one strut, and the system is configured so that the shaft forms a predetermined non-zero operating heel angle relative to vertical in the presence of a prevailing wind at a predetermined velocity. The blades and struts are airfoils with predetermined aerodynamic characteristics that generate lift forces with components in the direction of rotation around the shaft of the blades and struts at the operating heel angle to drive an electrical generator carried by the platform. The system can be designed to generate maximum power at the predetermined heel angle or essentially constant power over a range of heel angles.

Abstract: Methods are provided, in some aspects, for differentiating pluripotent cells into midbrain dopaminergic (DA) neurons using a mono-SMAD inhibition or inhibition of SMAD signaling with only one SMAD inhibitor. In some embodiments, mono-SMAD inhibition utilizes a single inhibitor of bone morphogenic protein (BMP) for differentiating pluripotent cells into midbrain DA neurons.

Abstract: An example implementation involves receiving measurements from an inertial sensor coupled to the robot and detecting an occurrence of a foot of the legged robot making contact with a surface. The implementation also involves reducing a gain value of an amplifier from a nominal value to a reduced value upon detecting the occurrence. The amplifier receives the measurements from the inertial sensor and provides a modulated output based on the gain value. The implementation further involves increasing the gain value from the reduced value to the nominal value over a predetermined duration of time after detecting the occurrence. The gain value is increased according to a profile indicative of a manner in which to increase the gain value of the predetermined duration of time. The implementation also involves controlling at least one actuator of the legged robot based on the modulated output during the predetermined duration of time.

Abstract: An apparatus, system, and method for a magnetically and releaseably attachable trigger for an instrument is provided. Additionally, the trigger provides for an increased sensitivity of sound by being in direct physical contact with the surface on which it is attached.

Abstract: A payment card (e.g., credit and/or debit card) or other device (e.g., mobile telephone) is provided with a magnetic emulator operable to communicate data to a magnetic stripe read-head. Data may include the type of reward that a user would like to earn as a result of making a purchase or the type of reward that a user would like to utilize to at least partially pay for a purchase.