Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. A method of using the sample plate and a kit comprising the sample plate is also disclosed.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. A method of using the sample plate and a kit comprising the sample plate is also disclosed.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.

Abstract: A system for inserting reagent or macrobeads into bores of a sample plate is disclosed comprising an insertion device arranged to retain one or more reagent or macrobeads by means of a vacuum whilst inserting the reagent or macrobeads into bores of the sample plate.

Abstract: A method of analyzing reagent beads retained in a sample well of a sample plate is disclosed comprising obtaining an image of a reagent bead, distributing intensity values of image pixels amongst a plurality of intensity bins and generating an histogram. A curve is fitted to the histogram and the curve is compared with an idealized profile of image pixels. A closeness of fit between the curve and the idealized profile is determined and then intensity values are discarded from one or more of the intensity bins. The remaining intensity values are redistributed and the process is repeated several times. A determination is then made as to which curve has the closest fit with the idealized profile.

Abstract: A system for inserting reagent or macrobeads into bores of a sample plate is disclosed comprising an insertion device arranged to retain one or more reagent or macrobeads by means of a vacuum whilst inserting the reagent or macrobeads into bores of the sample plate.

Abstract: A method of analysing reagent beads retained in a sample well of a sample plate is disclosed comprising obtaining an image of a reagent bead, distributing intensity values of image pixels amongst a plurality of intensity bins and generating an histogram. A curve is fitted to the histogram and the curve is compared with an idealised profile of image pixels. A closeness of fit between the curve and the idealised profile is determined and then intensity values are discarded from one or more of the intensity bins. The remaining intensity values are redistributed and the process is repeated several times. A determination is then made as to which curve has the closest fit with the idealised profile.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.

Abstract: An automated immunoassay apparatus is disclosed comprising a single optical reading device (2a, 2b) for reading two microtitre plates (9, 14). A first microtitre plate (9) is loaded into an upper plate holder (8) which is linearly translated at a fixed height. A second microtitre plate (14) is loaded into a lower plate holder (13). The lower plate holder (13) runs along a contoured track which varies the vertical height of the second microtitre plate (14).

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. A method of using the sample plate and a kit comprising the sample plate is also disclosed.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.

Abstract: A system for detecting the presence of a substantially transparent object includes a radiation source producing radiation at a predetermined bandwidth, and a radiation receiver is positioned to receive radiation from the radiation source. An opening is formed between the radiation receiver and the radiation source sized to allow a substantially transparent object such as a sample or reagent tip to slide between the radiation receiver and the radiation source. At least one polarizing filter is positioned between the radiation receiver and the opening, whereby a change in intensity of radiation received by the radiation receiver due to the presence or absence of the transparent object can be detected.

Abstract: A fluid level sensor and a washer unit are provided for an automated immonoassay processing system. A washer head (13) is vertically movable by a drive (2) above a reaction tray (8) having fluid (15) in separate cells. The level sensor comprises two electrodes arranged along a fluid path within aspirator tips (6). The electrodes are held at different electrical potentials and are effectively insulated from each other. If fluid is aspirated along the fluid path then the electrodes are bridged. Control means (1) is arranged to detect any change in conductance between the electrodes thereby indicating the presence of fluid (15). The vertical height of the washer head is determined relative to the sample thereby enabling the device to determine the level of the fluid (15).

Abstract: An external calibration system for a photo multiplier tube is described. The calibration system uses a light emitting diode and a photo cell wherein the diode is domed shaped. The light sensitive face of the photo multiplier tube is contained in the plane disposed at an acute angle to the longitudinal axis of the light emitting diode, and the photo cell is mounted substantially perpendicular to the longitudinal axis. A source of electrical energy then illuminates the light emitting diode over a range from, for example, 0 to 5 volts to generate light of known intensity and the light being generated is simultaneously measured by the photo cell and the light sensitive face of the photo multiplier tube. A feedback circuit is provided and associated circuitry so that a number of readings can be taken over a wide variety of light intensities to generate a calibration for the photo multiplier tube.