Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. A method of using the sample plate and a kit comprising the sample plate is also disclosed.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. A method of using the sample plate and a kit comprising the sample plate is also disclosed.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. A method of using the sample plate and a kit comprising the sample plate is also disclosed.

Abstract: A system for inserting reagent or macrobeads into bores of a sample plate is disclosed comprising an insertion device arranged to retain one or more reagent or macrobeads by means of a vacuum whilst inserting the reagent or macrobeads into bores of the sample plate.

Abstract: A method of analyzing reagent beads retained in a sample well of a sample plate is disclosed comprising obtaining an image of a reagent bead, distributing intensity values of image pixels amongst a plurality of intensity bins and generating an histogram. A curve is fitted to the histogram and the curve is compared with an idealized profile of image pixels. A closeness of fit between the curve and the idealized profile is determined and then intensity values are discarded from one or more of the intensity bins. The remaining intensity values are redistributed and the process is repeated several times. A determination is then made as to which curve has the closest fit with the idealized profile.

Abstract: A system for inserting reagent or macrobeads into bores of a sample plate is disclosed comprising an insertion device arranged to retain one or more reagent or macrobeads by means of a vacuum whilst inserting the reagent or macrobeads into bores of the sample plate.

Abstract: A method of analysing reagent beads retained in a sample well of a sample plate is disclosed comprising obtaining an image of a reagent bead, distributing intensity values of image pixels amongst a plurality of intensity bins and generating an histogram. A curve is fitted to the histogram and the curve is compared with an idealised profile of image pixels. A closeness of fit between the curve and the idealised profile is determined and then intensity values are discarded from one or more of the intensity bins. The remaining intensity values are redistributed and the process is repeated several times. A determination is then made as to which curve has the closest fit with the idealised profile.

Abstract: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.

Abstract: An automated immunoassay apparatus is disclosed comprising a single optical reading device (2a, 2b) for reading two microtitre plates (9, 14). A first microtitre plate (9) is loaded into an upper plate holder (8) which is linearly translated at a fixed height. A second microtitre plate (14) is loaded into a lower plate holder (13). The lower plate holder (13) runs along a contoured track which varies the vertical height of the second microtitre plate (14).

Abstract: An automated immunoassay apparatus is disclosed comprising a single optical reading device for reading two microtitre plates. A first microtitre plate is loaded into an upper plate holder which is linearly translated at a fixed height. A second microtitre plate is loaded into a lower plate holder. The lower plate, holder runs along a contoured track which varies the vertical height of the second microtitre plate.

Abstract: A system for detecting the presence of a substantially transparent object includes a radiation source producing radiation at a predetermined bandwidth, and a radiation receiver is positioned to receive radiation from the radiation source. An opening is formed between the radiation receiver and the radiation source sized to allow a substantially transparent object such as a sample or reagent tip to slide between the radiation receiver and the radiation source. At least one polarizing filter is positioned between the radiation receiver and the opening, whereby a change in intensity of radiation received by the radiation receiver due to the presence or absence of the transparent object can be detected.

Abstract: An external calibration system for a photo multiplier tube is described. The calibration system uses a light emitting diode and a photo cell wherein the diode is domed shaped. The light sensitive face of the photo multiplier tube is contained in the plane disposed at an acute angle to the longitudinal axis of the light emitting diode, and the photo cell is mounted substantially perpendicular to the longitudinal axis. A source of electrical energy then illuminates the light emitting diode over a range from, for example, 0 to 5 volts to generate light of known intensity and the light being generated is simultaneously measured by the photo cell and the light sensitive face of the photo multiplier tube. A feedback circuit is provided and associated circuitry so that a number of readings can be taken over a wide variety of light intensities to generate a calibration for the photo multiplier tube.

Abstract: A calibration system for a measuring device utilizing a photo multiplier tube is provided. The calibration system is intended to provide a stable light source variable over a wide range of intensities which can be used to calibrate the PMT reading using a closed loop feedback circuit. The LED and a photo cell are disposed in a reference block chamber whereby the photo cell is in close proximity disposed perpendicular to the axis of the LED. The LED being dome shaped will direct light energy on to the photo cell, and also peripherally. The PMT is disposed adjacent the LED and at an angle to its longitudinal axis whereby light generated by the PMT simultaneously strikes both the photo cell and the PMT without reflection.

Abstract: A method and procedure for color coding cuvettes used in laboratory tests without contaminating the interior thereof or changing its binding properties is described. In the procedure of this invention, transparent plastic cuvettes are utilized which are flat bottomed and have a depending rim surrounding the flat bottom. The depending surface of the rim then has color applied thereto by a conventional technique either hot stamping, or by ultra-violet cured silk screen printing. In either event, a colored surface is formed on the rim. The transparent walls of the cuvette then by light pipe effect give the appearance that the color surrounds the upper opening of such cuvette when in fact the opening is of transparent plastic.