Patents Assigned to Dyomics GmbH
  • Publication number: 20130045488
    Abstract: Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
    Type: Application
    Filed: August 10, 2012
    Publication date: February 21, 2013
    Applicants: Dyomics GmbH, Pierce Biotechnology, Inc.
    Inventors: Greg Hermanson, Peter T. Czerney, Surbhi Desai, Matthias S. Wenzel, Boguslawa Dworecki, Frank G. Lehmann, Marie Christine Nlend
  • Publication number: 20120294807
    Abstract: Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
    Type: Application
    Filed: December 20, 2011
    Publication date: November 22, 2012
    Applicants: DYOMICS GMBH, PIERCE BIOTECHNOLOGY, INC.
    Inventors: Greg Hermanson, Peter T. Czerney, Surbhi Desai, Matthias S. Wenzel, Boguslawa Dworecki, Frank G. Lehmann
  • Publication number: 20120156140
    Abstract: Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
    Type: Application
    Filed: December 20, 2011
    Publication date: June 21, 2012
    Applicants: DYOMICS GMBH, PIERCE BIOTECHNOLOGY, INC.
    Inventors: Greg Hermanson, Peter T. Czerney, Surbhi Desai, Matthias S. Wenzel, Boguslawa Dworecki, Frank G. Lehmann
  • Patent number: 7745640
    Abstract: Compounds, compositions, and methods for optical, including fluorescence optical, determinations useful in labelling biomolecules such as protein and deoxyribonucleic acid for their detection and quantitation. The compounds are diasteromeric cyanines with high hydrophilicity and other desirable properties.
    Type: Grant
    Filed: December 5, 2006
    Date of Patent: June 29, 2010
    Assignee: Dyomics GmbH
    Inventors: Peter T. Czerney, Wilhelm G. Frank, Frank G. Lehmann, Bernd G. Schweder, Matthias S. Wenzel
  • Patent number: 7563907
    Abstract: The invention relates to fluorescent dyes (fluorophores) based on polymethines for use in optical measurement and detection procedures, in particular those employing fluorescence, for example in medicine, in pharmacology and in the biological, materials and environmental sciences. The objective was to create fluorophores based on polymethines that have a large Stokes shift, high photostability, long storage life and a high fluorescent quantum yield, and that can be excited in the simplest possible manner by white-light sources or laser radiation in the UV, visible or NIR spectral region. According to the invention dyes on the basis of polymethines having the general formulas I, II or III are employed.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: July 21, 2009
    Assignee: Dyomics GmBH
    Inventors: Peter Czerney, Matthias Wenzel, Bernd Schweder, Frank Lehmann
  • Patent number: 7351829
    Abstract: The invention relates to compounds based on merocyanines with the general formulas I and/or II, where n=0 or an integer from 1 to 3, X=O or S and the residues R1 to R12 are the same or different and signify in particular hydrogen or various organic residues, without or with functional groups, and R2 incorporates an amine function. The compounds in accordance with the invention are suitable as fluorescent dyes (fluorophores) for used in optical determination and demonstration methods, in particular those employing fluorescence, for example in medicine, pharmacology and the biological, materials and environmental sciences. They are characterized by high photostability and long storage life, and exhibit a high fluorescence quantum yield. Excitation causing them to emit light can be achieved in a simple manner, by white-light sources or by laser irradiation in the UV, visible or NIR spectral region.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: April 1, 2008
    Assignee: Dyomics GmbH
    Inventors: Peter Czerney, Wilhelm Frank, Matthias Wenzel, Frank Lehmann
  • Publication number: 20070128659
    Abstract: Compounds, compositions, and methods for optical, including fluorescence optical, determinations useful in labelling biomolecules such as protein and deoxyribonucleic acid for their detection and quantitation. The compounds are diasteromeric cyanines with high hydrophilicity and other desirable properties.
    Type: Application
    Filed: December 5, 2006
    Publication date: June 7, 2007
    Applicant: DYOMICS GMBH
    Inventors: Peter Czerney, Wilhelm Frank, Frank Lehmann, Bernd Schweder, Matthias Wenzel
  • Patent number: 6924372
    Abstract: The present invention relates to the field of optical-fluorescent markers, particularly to benzopyrylo-polymethine-based optical-fluorescent markers.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: August 2, 2005
    Assignee: Dyomics GmbH
    Inventors: Peter Czerney, Matthias Wenzel, Bernd Schweder, Wilhelm Frank
  • Publication number: 20040260093
    Abstract: The invention relates to fluorescent dyes (fluorophores) based on polymethines for use in optical measurement and detection procedures, in particular those employing fluorescence, for example in medicine, in pharmacology and in the biological, materials and environmental sciences. The objective was to create fluorophores based on polymethines that have a large Stokes shift, high photostability, long storage life and a high fluorescent quantum yield, and that can be excited in the simplest possible manner by white-light sources or laser radiation in the UV, visible or NIR spectral region.
    Type: Application
    Filed: May 14, 2004
    Publication date: December 23, 2004
    Applicant: Dyomics GmbH
    Inventors: Peter Czerney, Matthias Wenzel, Bernd Schweder, Frank Lehmann
  • Publication number: 20030165942
    Abstract: The invention relates to fluorescent dyes (fluorophores) based on polymethines for use in optical measurement and detection procedures, in particular those employing fluorescence, for example in medicine, in pharmacology and in the biological, materials and environmental sciences.
    Type: Application
    Filed: December 5, 2002
    Publication date: September 4, 2003
    Applicant: Dyomics GmbH
    Inventors: Peter Czerney, Matthias Wenzel, Bernd Schweder, Frank Lehmann
  • Publication number: 20030045717
    Abstract: The invention relates to compounds based on merocyanines with the general formulas I and/or II, 1
    Type: Application
    Filed: July 3, 2002
    Publication date: March 6, 2003
    Applicant: Dyomics GmbH
    Inventors: Peter Czerney, Matthias Wenzel, Wilhelm Frank, Frank Lehmann