Abstract: An oral gel composition suitable for the treatment of oral leukoplakia comprising a combination of diclofenac with hyaluronic acid and methods of administering the oral gel that may include a device that prolongs contact time of the oral gel with the areas of the mucosa that are affected by oral leukoplakia.
Abstract: A method of enhancing absorption of a therapeutic agent sublingually in a person configured to treat chronic graft-versus-host disease (cGVHD) or aphthous stomatitis. The method includes administering a therapeutically effective amount of the therapeutic agent sublingually in a person and then inserting for a predetermined treatment period a device in an oral cavity of the person, wherein the device comprising an oral retention portion that is configured to be retained in the oral cavity from the predetermined treatment period and further configured to enhance absorption of the therapeutic agent sublingually.
Abstract: A method of enhancing absorption of a therapeutic agent sublingually in a person. The method includes administering a therapeutically effective amount of the therapeutic agent sublingually in a person and then inserting for a predetermined treatment period a device in an oral cavity of the person, wherein the device comprising an oral retention portion that is configured to be retained in the oral cavity from the predetermined treatment period and further configured to enhance absorption of the therapeutic agent sublingually.
Abstract: A method and device for the prevention and treatment of oral mucositis using a combination of an anti-mucositis agent and the device that is held in place for prolonged periods of time within the mouth. Portions of the device overlie and are brought into direct contact with the portions of the oral mucosa that are affected by oral mucositis. The method provides prolonged contact time of the anti-mucositis agents to the areas of the mucosa that are affected by oral mucositis. The combination may be used to treat oral mucositis or, prophylactically, to prevent oral mucositis that may occur in patients that receive chemotherapy and/or radiation therapy.