Abstract: Various aspects of an ion-gated nanochannel catalytic membrane reactor, disclosed herein. The ion-gated nanochannel catalytic membrane reactor includes a reaction unit comprising at least a plurality of reactants that react to produce one or more permeates at least due to activation by a catalyst. The membrane reactor further includes a separation unit including an ion-gated nanochannel membrane supported on a hollow fiber support. The polar permeates from the one or more permeates pass through the ion-gated nanochannel membrane and are separated in-situ. Multiple methods/processes using the ion-gated nanochannel catalytic membrane reactor for chemicals and fuels production are included.