Abstract: A mini-distillation and reflux system, kit and method in which a heating and glassware arrangement includes a heat source in contact with a heater block having apertures in its top surface for housing boiling tubes upright during a distillation or reflux operation. The boiling tubes contain sample and are for attachment of various configurations of glassware assemblies made up of individual, interchangeably connectable glassware pieces so assembled to perform different types of distillations and refluxes. The glassware pieces are of a scaled down size so that numerous distillations and refluxes can be performed simultaneously at a single heat source within a compact space to consume less laboratory space.