Abstract: An MRI contrast medium of improved safety and efficacy is disclosed. The composition includes a source of calcium ions and a source of manganese ions in a ratio of from 2:1 to 40:1 in a vehicle suitable for parenteral administration. A method of enhancing an MRI signal in a mammalian tissue with the foregoing composition is also provided.
Type:
Grant
Filed:
November 2, 1998
Date of Patent:
November 9, 1999
Assignee:
Eagle Vision Pharmaceutical Corporation
Inventors:
Phillip P. Harnish, Peter R. Seoane, Adele R. Vessey