Patents Assigned to Earlow Limited
  • Diagnosis and treatment of a disorder of the gastrointestinal tract
    Patent number: 5403848
    Abstract: Cyproheptadine (4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine) for the treatment of non-ulcerative dyspepsia (NUD), more particularly NUD which is characterized by dysfunction of central 5-HT 1A receptors. Dysfunction of the central 5-HT 1A receptors can be diagnosed by an azaspirodecanedione-induced prolactin response which is distinguishable from that observed in a subject with peptic ulcer disease and/or inflammatory bowel disease. A suitable azaspirodecanedione for inducing the prolactin response is buspirone.
    Type: Grant
    Filed: December 28, 1993
    Date of Patent: April 4, 1995
    Assignee: Earlow Limited
    Inventors: Timothy G. Dinan, Paul W. N. Keeling
  • Diagnosis and treatment of a disorder of the gastrointestinal tract
    Patent number: 5324738
    Abstract: Cyproheptadine (4-(5H-dibenzo[a,d] cyclohepten-5-ylidene)-1-methylpiperidine) for the treatment of non-ulcerative dyspepsia (NUD), more particularly NUD which is characterised by dysfunction of central 5-HT 1A receptors. Dysfunction of the central 5-HT 1A receptors can be diagnosed by an azaspirodecanedione-induced prolactin response which is distinguishable from that observed in a subject with peptic ulcer disease and/or inflammatory bowel disease. A suitable azaspirodecanedione for inducing the prolactin response is buspirone.
    Type: Grant
    Filed: September 18, 1990
    Date of Patent: June 28, 1994
    Assignee: Earlow Limited
    Inventors: Timothy G. Dinan, Paul W. N. Keeling