Abstract: A method of treating a subject suffering from an ischemic disease associated with Ca2+ overload is provided, the method including administering to the subject an effective amount of an inhibitor of Ataxia telangiectasia and Rad3-related (ATR) kinase. Also provided is a method of treating a subject suffering from acute ischemic stroke, the method including administering to the subject an effective amount of the ATR kinase inhibitor berzosertib.
Type:
Grant
Filed:
November 8, 2019
Date of Patent:
October 31, 2023
Assignee:
EAST TENNESSEE STATE UNIVERSITY RESEARCH FOUNDATIO