Patents Assigned to East Tennessee State University
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Publication number: 20180361158Abstract: Multi-modal stimulation therapy may be utilized in which two or more stimulation therapies having different stimulation parameters may be delivered to a single patient. This can preferentially stimulate different nerve fiber types and drive different functional responses in the target organs. The stimulation parameters that may vary between the different stimulation therapies include, for example, pulse frequency, pulse width, pulse amplitude, and duty cycle.Type: ApplicationFiled: June 14, 2018Publication date: December 20, 2018Applicants: Cyberonics, Inc., East Tennessee State UniversityInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell, Gregory A. Ordway
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Publication number: 20180243566Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A computer-implemented control system is operated to automatically identify a neural fulcrum zone based on a monitored patient physiological response. Ongoing neurostimulation therapy is delivered within the neural fulcrum zone.Type: ApplicationFiled: April 20, 2018Publication date: August 30, 2018Applicants: Cyberonics, Inc., East Tennessee State UniversityInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
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Patent number: 9999773Abstract: Multi-modal stimulation therapy may be utilized in which two or more stimulation therapies having different stimulation parameters may be delivered to a single patient. This can preferentially stimulate different nerve fiber types and drive different functional responses in the target organs. The stimulation parameters that may vary between the different stimulation therapies include, for example, pulse frequency, pulse width, pulse amplitude, and duty cycle.Type: GrantFiled: October 22, 2014Date of Patent: June 19, 2018Assignees: Cyberonics, Inc., East Tennessee State UniversityInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell, Gregory A. Ordway
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Publication number: 20180126170Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.Type: ApplicationFiled: October 13, 2017Publication date: May 10, 2018Applicants: CYBERONICS, INC., EAST TENNESSEE STATE UNIVERSITYInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
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Publication number: 20180117333Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.Type: ApplicationFiled: November 6, 2017Publication date: May 3, 2018Applicants: CYBERONICS, INC., East Tennessee State UniversityInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
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Patent number: 9950169Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A computer-implemented control system is operated to automatically identify a neural fulcrum zone based on a monitored patient physiological response. Ongoing neurostimulation therapy is delivered within the neural fulcrum zone.Type: GrantFiled: April 25, 2014Date of Patent: April 24, 2018Assignees: Cyberonics, Inc., East Tennessee State UniversityInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
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Publication number: 20170319854Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.Type: ApplicationFiled: May 19, 2017Publication date: November 9, 2017Applicants: CYBERONICS, INC., EAST TENNESSEE STATE UNIVERSITYInventors: Bruce H. KenKnight, Jeffrey L. Ardell, Imad Libbus, Badri Amurthur
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Patent number: 9808626Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.Type: GrantFiled: September 16, 2016Date of Patent: November 7, 2017Assignees: Cyberonics, Inc., East Tennessee State UniversityInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
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Publication number: 20170296824Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone may be identified by monitoring a patient's response to incrementally increased intensity settings at a first frequency. If the incremental intensity increases do not result in the identification of the neural fulcrum zone, the frequency may be changed to provide finer resolution identification of the neural fulcrum zone.Type: ApplicationFiled: May 3, 2017Publication date: October 19, 2017Applicants: CYBERONICS, INC., EAST TENNESSEE STATE UNIVERSITYInventors: Bruce H. KenKnight, Imad Libbus, Badri Amurthur, Jeffrey L. Ardell
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Patent number: 9789316Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.Type: GrantFiled: August 12, 2016Date of Patent: October 17, 2017Assignees: CYBERONICS, INC., EAST TENNESSEE STATE UNIVERSITYInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
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Patent number: 9713719Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone may be identified by monitoring a patient's response to incrementally increased intensity settings at a first frequency. If the incremental intensity increases do not result in the identification of the neural fulcrum zone, the frequency may be changed to provide finer resolution identification of the neural fulcrum zone.Type: GrantFiled: April 17, 2014Date of Patent: July 25, 2017Assignees: CYBERONICS, INC., EAST TENNESSEE STATE UNIVERSITYInventors: Bruce H. KenKnight, Imad Libbus, Badri Amurthur, Jeffrey L. Ardell
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Patent number: 9669220Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.Type: GrantFiled: August 5, 2016Date of Patent: June 6, 2017Assignees: CYBERONICS, INC., EAST TENNESSEE STATE UNIVERSITYInventors: Bruce H. KenKnight, Jeffrey L. Ardell, Imad Libbus, Badri Amurthur
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Publication number: 20170001012Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.Type: ApplicationFiled: September 16, 2016Publication date: January 5, 2017Applicants: CYBERONICS, INC., East Tennessee State UniversityInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
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Publication number: 20160346549Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.Type: ApplicationFiled: August 12, 2016Publication date: December 1, 2016Applicants: CYBERONICS, INC., EAST TENNESSEE STATE UNIVERSITYInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
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Publication number: 20160339252Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.Type: ApplicationFiled: August 5, 2016Publication date: November 24, 2016Applicants: CYBERONICS, INC., EAST TENNESSEE STATE UNIVERSITYInventors: Bruce H. KenKnight, Jeffrey L. Ardell, Imad Libbus, Badri Amurthur
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Patent number: 9446237Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.Type: GrantFiled: September 22, 2015Date of Patent: September 20, 2016Assignees: CYBERONICS, INC., EAST TENNESSEE STATE UNIVERSITYInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
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Patent number: 9415224Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.Type: GrantFiled: April 25, 2014Date of Patent: August 16, 2016Assignees: CYBERONICS, INC., EAST TENNESSEE STATE UNIVERSITYInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
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Patent number: 9272143Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time, and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.Type: GrantFiled: May 7, 2014Date of Patent: March 1, 2016Assignees: CYBERONICS, INC., East Tennessee State UniversityInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
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Patent number: 8227210Abstract: Positive controls for experimentation related to membrane-bound glucose transporter proteins and methods for preparing such positive controls, such proteins including GLUT1, GLUT4, GLUT5, and GLUT12.Type: GrantFiled: December 11, 2009Date of Patent: July 24, 2012Assignee: East Tennessee State University Research FoundationInventor: Charles A. Stuart
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Patent number: 7866983Abstract: Disclosed is a surgical simulator for teaching, practicing, and evaluating surgical techniques. Such a simulator may comprise a cassette of organs, blood vessels, and tissues that may be disposable. The simulator also comprises a hemodynamic simulator and a frame assembly, the frame assembly providing support for the cassette of organs as well as a fluid conduit through which simulated blood flow from the hemodynamic simulator may be connected to the blood vessels of the organs and related tissues. The hemodynamic simulator provides adjustable and variable pressures to the arteries and veins, as well as variable pulse rates, which can be programmed at settings chosen by an instructor or user.Type: GrantFiled: January 16, 2007Date of Patent: January 11, 2011Assignee: East Tennessee State University Research FoundationInventors: William K. Hemphill, J. Paul Sims, Martin E. Olsen, Martin P. Eason, Sheldon R. Davis