Patents Assigned to Eastern Kentucky University
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Patent number: 12152089Abstract: The conjugation of luteinizing hormone-releasing hormone (LHRH) with activated cisplatin using a malonate linker gives rise to a new Platinum-LHRH conjugate that effectively targets tumor cells that express the LHRH receptor. The Pt-LHRH conjugate may be used in a method for killing or inhibiting the growth of a tumor cell, especially in late state, highly invasive and aggressive stage IV tumors and in reoccurring tumors.Type: GrantFiled: November 19, 2021Date of Patent: November 26, 2024Assignee: Eastern Kentucky UniversityInventors: Margaret Ndinguri, Lindsay Cormier
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Publication number: 20240271178Abstract: The present disclosure concerns systems and methods for detecting contaminants such as E. coli in water samples from rivers, lakes, or other sources of drinking water to expeditiously and inexpensively identify microbial contamination, wherein a water sample is mixed with a growth medium and a substrate to form a mixture, wherein the presence of a contaminant allows for metabolism of the substrate and detection thereof. In some aspects, equal amounts of the mixture are placed into individual wells, incubated and then visualized under UV light. Individual wells positive for the metabolite of the substrate can be counted and the number of glowing wells corresponds to the most probable number of contaminant in the sample volume.Type: ApplicationFiled: February 19, 2021Publication date: August 15, 2024Applicant: EASTERN KENTUCKY UNIVERSITYInventor: Jason Wayne Marion
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Patent number: 11197888Abstract: The conjugation of luteinizing hormone-releasing hormone (LHRH) with activated cisplatin using a malonate linker gives rise to a new Platinum-LHRH conjugate that effectively targets tumor cells that express the LHRH receptor. The Pt-LHRH conjugate may be used in a method for killing or inhibiting the growth of a tumor cell, especially in late state, highly invasive and aggressive stage IV tumors and in reoccurring tumors.Type: GrantFiled: October 12, 2018Date of Patent: December 14, 2021Assignee: Eastern Kentucky UniversityInventors: Margaret Ndinguri, Lindsay Calderon
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Publication number: 20190111077Abstract: The conjugation of luteinizing hormone-releasing hormone (LHRH) with activated cisplatin using a malonate linker gives rise to a new Platinum-LHRH conjugate that effectively targets tumor cells that express the LHRH receptor. The Pt-LHRH conjugate may be used in a method for killing or inhibiting the growth of a tumor cell, especially in late state, highly invasive and aggressive stage IV tumors and in reoccurring tumors.Type: ApplicationFiled: October 12, 2018Publication date: April 18, 2019Applicant: Eastern Kentucky UniversityInventors: Margaret Ndinguri, Lindsay Calderon
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Patent number: 10130717Abstract: The conjugation of luteinizing hormone-releasing hormone (LHRH) with activated cisplatin using a malonate linker gives rise to a new Platinum-LHRH conjugate that effectively targets tumor cells that express the LHRH receptor. The Pt-LHRH conjugate may be used in a method for killing or inhibiting the growth of a tumor cell, especially in late state, highly invasive and aggressive stage IV tumors and in reoccurring tumors.Type: GrantFiled: December 2, 2016Date of Patent: November 20, 2018Assignee: Eastern Kentucky UniversityInventors: Margaret Ndinguri, Lindsay Calderon
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Patent number: 9784571Abstract: To obtain a three-dimensional virtual reconstruction of a workpiece the workpiece is positioned on a display screen between the display screen and at least one imager wherein the imager acquires multiple images of the workpiece while (a) multiple light stripes are displayed and swept in a first directional orientation across the display screen, (b) multiple light stripes are displayed and swept in at least one second directional orientation across the display screen, and (c) multiple images for each position of the multiple light stripes at different exposure times are captured. From the multiple images, a difference caused by the workpiece in a width and a profile of the multiple light stripes is determined. That difference is used to calculate a depth value (z) of the workpiece at each imager pixel position (x, y). The calculated depth value is used to reconstruct a surface shape of the workpiece.Type: GrantFiled: May 15, 2014Date of Patent: October 10, 2017Assignee: Eastern Kentucky UniversityInventor: George V. Landon
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Publication number: 20170157263Abstract: The conjugation of luteinizing hormone-releasing hormone (LHRH) with activated cisplatin using a malonate linker gives rise to a new Platinum-LHRH conjugate that effectively targets tumor cells that express the LHRH receptor. The Pt-LHRH conjugate may be used in a method for killing or inhibiting the growth of a tumor cell, especially in late state, highly invasive and aggressive stage IV tumors and in reoccurring tumors.Type: ApplicationFiled: December 2, 2016Publication date: June 8, 2017Applicant: Eastern Kentucky UniversityInventors: Margaret Ndinguri, Lindsay Calderon
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Publication number: 20140340485Abstract: Methods and systems for three-dimensional virtual reconstruction of a workpiece surface are provided. A workpiece is positioned on a display screen between the display screen and at least one imager. The imager acquires multiple images of the workpiece while (a) multiple light stripes are displayed and swept in a first directional orientation across the display screen, (b) multiple light stripes are displayed and swept in at least one second directional orientation across the display screen, and (c) multiple images for each position of the multiple light stripes at different exposure times are captured. From the multiple images, a difference caused by the workpiece in a width and a profile of the multiple light stripes is determined. That difference is used to calculate a depth value (z) of the workpiece at each imager pixel position (x, y). The calculated depth value is used to reconstruct a surface shape of the workpiece.Type: ApplicationFiled: May 15, 2014Publication date: November 20, 2014Applicant: Eastern Kentucky UniversityInventor: George V. Landon