Patents Assigned to Eastern Virginia Medical School of the Medical College fo Hampton Roads
  • High level of expression of ingap in bacterial and euraryotic cells
    Patent number: 5804421
    Abstract: Removal of the nucleotide sequence encoding the signal peptide from the INGAP coding sequence allows cultured cells to express substantial amounts of INGAP activity. Previous attempts have provided only low yields of INGAP, possibly because the signal sequence of INGAP is toxic to the cells.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: September 8, 1998
    Assignee: Eastern Virginia Medical School of the Medical College fo Hampton Roads
    Inventors: Aaron I. Vinik, Gary L. Pittenger, Ronit Rafaeloff-Phail, Scott W. Barlow