Patents Assigned to Eberhard-Karls Universität Tübingen Universitätsklinikum
  • Patent number: 10571389
    Abstract: The present invention relates to a method for the visual examination of biological material ex vivo and an apparatus for the sterical orientation of biological material which can be used in said method.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: February 25, 2020
    Assignee: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventor: Matthias Moehrle
  • Patent number: 9821016
    Abstract: The present invention relates to a genetically modified Paramyxovirus, a pharmaceutical composition comprising this paramyxovirus, the use of a genetically modified Paramyxovirus for the therapeutic and/or prophylactic treatment of a tumor disease, and a method for the production of a pharmaceutical composition for the therapeutic or prophylactic treatment of a tumor disease.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: November 21, 2017
    Assignee: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventors: Ulrich Manfred Lauer, Michael Bitzer, Martina Zimmermann, Sorin Armeanu-Ebinger, Sascha Bossow, Wolfgang Neubert
  • Patent number: 9580686
    Abstract: The present invention relates to the use of at least one antibody which binds to the SUSD2 antigen, or to functional fragments of the antibody, in combination with at least one of the following: an antibody which binds to CD140b, an antibody which binds to CD56, and/or an antibody which binds to TNAP, or functional fragments thereof, for isolation of mesenchymal stem cells, especially those having particularly chondrocytic and osteogenic differentiation potential. The invention further relates to processes for isolating such stem cells using these antibodies.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: February 28, 2017
    Assignee: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventors: Hans-Jorg Buhring, Sabrina Grimm, Flavianna Cerabona
  • Patent number: 9283389
    Abstract: The present invention relates to a method of treating movement disorders of a living being, a method of treating refractory gait disturbances of a human Parkinson's disease patient being affected by gait disturbances, and an apparatus for deep brain stimulation (DBS) of a living being affected by movement disorders.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: March 15, 2016
    Assignee: Eberhard-Karls-Universität Tübingen Universitätsklinikum
    Inventors: Rejko Krueger, Daniel Weiss
  • Patent number: 9127281
    Abstract: The present invention relates to a nucleic acid molecule, a genetic construct, siRNA molecules and a composition which comprises the nucleic acid molecule and/or the genetic construct and/or the siRNA molecules and can be used for inhibition of the expression of endothelial adhesion molecules. The invention also relates to a device, which is coated with the aforementioned molecules, the composition or the construct, or contains them. The present invention further relates to a corresponding use of the nucleic acid molecule, of the genetic construct or of the siRNA molecules and a method of inhibition of the expression of adhesion molecules and a method of vessel grafting, lung transplantation, treatment of lung transplants, and a method of treatment of the open heart within the scope of cardioplegia.
    Type: Grant
    Filed: January 19, 2006
    Date of Patent: September 8, 2015
    Assignee: Eberhard-Karls-Universität Tübingen Universitätsklinikum
    Inventors: Tobias Walker, Hans-Peter Wendel
  • Patent number: 9079938
    Abstract: The present invention relates to a method for the in vitro determination of the presence of or a predisposition of a patient to the development of cancer. In the method according to the invention, the presence of a marker is determined in a biological sample of the patient, said marker being selected from a) the amino acid sequence SEQ ID No. 2 from the sequence protocol that is provided, or b) a nucleic acid that encodes the amino acid sequence with the SEQ ID No. 2. The invention further relates to the amino acid and the encoding nucleic acid and to the use thereof in diagnostics and for molecular therapeutic approaches.
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: July 14, 2015
    Assignee: Eberhard-Karls-Universität Tübingen Universitätsklinikum
    Inventors: Kerstin Kampa-Schittenhelm, Marcus Schittenhelm
  • Patent number: 9078073
    Abstract: In a hearing aid having a microphone to be arranged at a body of a user for capturing ambient sound, a loudspeaker for outputting the ambient sound after having been amplified on a frequency-dependent basis, and a signal processor, the signal processor is configured to amplify the sound such that the amplified sound is audible to the user, and to automatically re-adjust the gain by the following steps: selecting a tone having a specific frequency; outputting the tone and the amplified ambient sound via the loudspeaker as an output sound; capturing via said microphone an analysis sound composed of ambient sound and of a reflection of said output sound; extracting a reflection of the tone from the captured analysis sound; and determining a reflection component for the specific frequency of the tone; adjusting the gain in frequency-specific manner and based on the determined reflection component.
    Type: Grant
    Filed: July 4, 2012
    Date of Patent: July 7, 2015
    Assignee: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventors: Erich Goll, Ernst Dalhoff, Hans-Peter Zenner
  • Patent number: 9052316
    Abstract: The present invention relates to a method for isolating and/or identifying stem cells having adipocytic, chondrocytic and pancreatic differentiation potential, wherein an antibody is used that binds to the antigen TNAP, alone or in combination with an antibody that binds to the cell surface antigen CD56. The invention also relates to stem cells isolated by the method according to the invention for treating defects or damages or diseases in bone or cartilage of a patient in need thereof.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: June 9, 2015
    Assignee: EBERHARD-KARLS-UNIVERSITAET TUEBINGEN UNIVERSITAETSKLINIKUM
    Inventors: Hans-Joerg Buehring, Sabrina Treml, Reiner Lammers
  • Patent number: 9029119
    Abstract: The present invention relates to a composition for the cultivation of sophisticated bacteria, preferably of the genus Bartonella, and to a method for the cultivation of these bacteria.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: May 12, 2015
    Assignee: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventor: Volkhard Kempf
  • Publication number: 20140193010
    Abstract: In a hearing aid having a microphone to be arranged at a body of a user for capturing ambient sound, a loudspeaker for outputting the ambient sound after having been amplified on a frequency-dependent basis, and a signal processor, the signal processor is configured to amplify the sound such that the amplified sound is audible to the user, and to automatically re-adjust the gain by the following steps: selecting a tone having a specific frequency; outputting the tone and the amplified ambient sound via the loudspeaker as an output sound; capturing via said microphone an analysis sound composed of ambient sound and of a reflection of said output sound; extracting a reflection of the tone from the captured analysis sound; and determining a reflection component for the specific frequency of the tone; adjusting the gain in frequency-specific manner and based on the determined reflection component.
    Type: Application
    Filed: July 4, 2012
    Publication date: July 10, 2014
    Applicant: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventors: Erich Goll, Ernst Dalhoff, Hans-Peter Zenner
  • Patent number: 8691183
    Abstract: The present invention relates to a composition for the detection and the treatment of prostate cells and to methods for the diagnostic and therapeutic treatment of a human being using the composition according to the invention.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: April 8, 2014
    Assignee: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventor: Stefan Heckl
  • Patent number: 8618178
    Abstract: The invention relates to methods for treating T cell mediated autoimmune diseases, such as psoriasis and multiple sclerosis, in a human in need thereof, wherein a therapeutically effective amount of a substance which lowers the cellular glutathione content is administered to the human.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: December 31, 2013
    Assignee: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventors: Martin Roecken, Kamran Ghoreschi, Christina Mathilde Weigert
  • Publication number: 20130331906
    Abstract: The present invention relates to a method of treating movement disorders of a living being, a method of treating refractory gait disturbances of a human Parkinson's disease patient being affected by gait disturbances, and an apparatus for deep brain stimulation (DBS) of a living being affected by movement disorders.
    Type: Application
    Filed: June 11, 2012
    Publication date: December 12, 2013
    Applicant: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventors: Rejko Krueger, Daniel Weiss
  • Publication number: 20130122078
    Abstract: The present invention relates to a method for the implantation of biological material into an organism.
    Type: Application
    Filed: January 4, 2013
    Publication date: May 16, 2013
    Applicant: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventor: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
  • Publication number: 20130108580
    Abstract: The present invention relates to a fusion protein comprising a) a first polypeptide selected from among SDF-1 (stromal cell derived factor-1) or peptidase/protease-resistant variants or fragments thereof which have the CXCR4-/CXCR7- binding function of SDF-1; and b) a second polypeptide which is selected from among GPVI (glycoprotein VI), or the extracellular domain of GPVI, or fragments or variants of the extracellular domain of GPVI which contain the collagen binding function of GPVI, wherein the first polypeptide and the second peptide are linked to one another directly or via a linker molecule. The invention furthermore relates to the use of the fusion protein for treating diseases.
    Type: Application
    Filed: September 28, 2012
    Publication date: May 2, 2013
    Applicant: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventor: Eberhard-Karls-Universitaet Tuebingen Universita
  • Publication number: 20130078219
    Abstract: The present invention relates to a genetically modified Paramyxovirus, a pharmaceutical composition comprising this paramyxovirus, the use of a genetically modified Paramyxovirus for the therapeutic and/or prophylactic treatment of a tumor disease, and a method for the production of a pharmaceutical composition for the therapeutic or prophylactic treatment of a tumor disease.
    Type: Application
    Filed: October 22, 2012
    Publication date: March 28, 2013
    Applicant: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventor: Eberhard-Karls-Universitaet Tuebingen Universitaet
  • Publication number: 20130078648
    Abstract: The present invention relates to a method for the visual examination of biological material ex vivo and an apparatus for the sterical orientation of biological material which can be used in said method.
    Type: Application
    Filed: November 16, 2012
    Publication date: March 28, 2013
    Applicant: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventor: Eberhard-Karls-Universitaet Tuebingen Universita
  • Patent number: 8163495
    Abstract: The present invention concerns antibodies produced from hybridoma cell lines chosen from the group comprising W8B2, W1C3, W7C6, W5C4, 24D2, 28D4, HEK-3D6, W4A5, W3D5, W5C5, 9A3G9, 58B1, F9-3C2F1, 39D5, for isolating and/or identifying homogenous mesenchymal stem cells. Furthermore a method is presented with which mesenchymal stem cells from adult primary tissue, for example bone marrow, can be identified and isolated with a high level of purity.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: April 24, 2012
    Assignee: Eberhard-Karls-Universität Tuebingen Universitaetsklinikum
    Inventors: Hans-Jorg Buhring, Reiner Lammers, Sabrina Treml, Venkata Lokesh Battula
  • Patent number: 8143223
    Abstract: The present invention relates to a method for protecting biological material from cell damaging factors, a method for producing a pharmaceutical composition for the prophylactic and/or therapy accompanying treatment of radiation therapy patients and/or chemotherapy patients, a cosmetic composition, and a culture medium.
    Type: Grant
    Filed: October 2, 2003
    Date of Patent: March 27, 2012
    Assignee: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventors: Klaus Dittmann, Claus Mayer, Peter Rodemann
  • Publication number: 20110165065
    Abstract: The present invention relates to a composition for the detection and the treatment of prostate cells and to methods for the diagnostic and therapeutic treatment of a human being using the composition according to the invention.
    Type: Application
    Filed: February 8, 2011
    Publication date: July 7, 2011
    Applicant: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventor: Stefan Heckl