Patents Assigned to Eberhard-Karls Universität Tübingen
Universitätsklinikum
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Patent number: 10571389Abstract: The present invention relates to a method for the visual examination of biological material ex vivo and an apparatus for the sterical orientation of biological material which can be used in said method.Type: GrantFiled: November 16, 2012Date of Patent: February 25, 2020Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventor: Matthias Moehrle
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Patent number: 9821016Abstract: The present invention relates to a genetically modified Paramyxovirus, a pharmaceutical composition comprising this paramyxovirus, the use of a genetically modified Paramyxovirus for the therapeutic and/or prophylactic treatment of a tumor disease, and a method for the production of a pharmaceutical composition for the therapeutic or prophylactic treatment of a tumor disease.Type: GrantFiled: October 22, 2012Date of Patent: November 21, 2017Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Ulrich Manfred Lauer, Michael Bitzer, Martina Zimmermann, Sorin Armeanu-Ebinger, Sascha Bossow, Wolfgang Neubert
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Patent number: 9580686Abstract: The present invention relates to the use of at least one antibody which binds to the SUSD2 antigen, or to functional fragments of the antibody, in combination with at least one of the following: an antibody which binds to CD140b, an antibody which binds to CD56, and/or an antibody which binds to TNAP, or functional fragments thereof, for isolation of mesenchymal stem cells, especially those having particularly chondrocytic and osteogenic differentiation potential. The invention further relates to processes for isolating such stem cells using these antibodies.Type: GrantFiled: September 22, 2014Date of Patent: February 28, 2017Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Hans-Jorg Buhring, Sabrina Grimm, Flavianna Cerabona
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Patent number: 9283389Abstract: The present invention relates to a method of treating movement disorders of a living being, a method of treating refractory gait disturbances of a human Parkinson's disease patient being affected by gait disturbances, and an apparatus for deep brain stimulation (DBS) of a living being affected by movement disorders.Type: GrantFiled: June 11, 2012Date of Patent: March 15, 2016Assignee: Eberhard-Karls-Universität Tübingen UniversitätsklinikumInventors: Rejko Krueger, Daniel Weiss
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Patent number: 9127281Abstract: The present invention relates to a nucleic acid molecule, a genetic construct, siRNA molecules and a composition which comprises the nucleic acid molecule and/or the genetic construct and/or the siRNA molecules and can be used for inhibition of the expression of endothelial adhesion molecules. The invention also relates to a device, which is coated with the aforementioned molecules, the composition or the construct, or contains them. The present invention further relates to a corresponding use of the nucleic acid molecule, of the genetic construct or of the siRNA molecules and a method of inhibition of the expression of adhesion molecules and a method of vessel grafting, lung transplantation, treatment of lung transplants, and a method of treatment of the open heart within the scope of cardioplegia.Type: GrantFiled: January 19, 2006Date of Patent: September 8, 2015Assignee: Eberhard-Karls-Universität Tübingen UniversitätsklinikumInventors: Tobias Walker, Hans-Peter Wendel
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Patent number: 9079938Abstract: The present invention relates to a method for the in vitro determination of the presence of or a predisposition of a patient to the development of cancer. In the method according to the invention, the presence of a marker is determined in a biological sample of the patient, said marker being selected from a) the amino acid sequence SEQ ID No. 2 from the sequence protocol that is provided, or b) a nucleic acid that encodes the amino acid sequence with the SEQ ID No. 2. The invention further relates to the amino acid and the encoding nucleic acid and to the use thereof in diagnostics and for molecular therapeutic approaches.Type: GrantFiled: January 29, 2013Date of Patent: July 14, 2015Assignee: Eberhard-Karls-Universität Tübingen UniversitätsklinikumInventors: Kerstin Kampa-Schittenhelm, Marcus Schittenhelm
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Patent number: 9078073Abstract: In a hearing aid having a microphone to be arranged at a body of a user for capturing ambient sound, a loudspeaker for outputting the ambient sound after having been amplified on a frequency-dependent basis, and a signal processor, the signal processor is configured to amplify the sound such that the amplified sound is audible to the user, and to automatically re-adjust the gain by the following steps: selecting a tone having a specific frequency; outputting the tone and the amplified ambient sound via the loudspeaker as an output sound; capturing via said microphone an analysis sound composed of ambient sound and of a reflection of said output sound; extracting a reflection of the tone from the captured analysis sound; and determining a reflection component for the specific frequency of the tone; adjusting the gain in frequency-specific manner and based on the determined reflection component.Type: GrantFiled: July 4, 2012Date of Patent: July 7, 2015Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Erich Goll, Ernst Dalhoff, Hans-Peter Zenner
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Patent number: 9052316Abstract: The present invention relates to a method for isolating and/or identifying stem cells having adipocytic, chondrocytic and pancreatic differentiation potential, wherein an antibody is used that binds to the antigen TNAP, alone or in combination with an antibody that binds to the cell surface antigen CD56. The invention also relates to stem cells isolated by the method according to the invention for treating defects or damages or diseases in bone or cartilage of a patient in need thereof.Type: GrantFiled: December 28, 2010Date of Patent: June 9, 2015Assignee: EBERHARD-KARLS-UNIVERSITAET TUEBINGEN UNIVERSITAETSKLINIKUMInventors: Hans-Joerg Buehring, Sabrina Treml, Reiner Lammers
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Patent number: 9029119Abstract: The present invention relates to a composition for the cultivation of sophisticated bacteria, preferably of the genus Bartonella, and to a method for the cultivation of these bacteria.Type: GrantFiled: October 25, 2010Date of Patent: May 12, 2015Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventor: Volkhard Kempf
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Publication number: 20140193010Abstract: In a hearing aid having a microphone to be arranged at a body of a user for capturing ambient sound, a loudspeaker for outputting the ambient sound after having been amplified on a frequency-dependent basis, and a signal processor, the signal processor is configured to amplify the sound such that the amplified sound is audible to the user, and to automatically re-adjust the gain by the following steps: selecting a tone having a specific frequency; outputting the tone and the amplified ambient sound via the loudspeaker as an output sound; capturing via said microphone an analysis sound composed of ambient sound and of a reflection of said output sound; extracting a reflection of the tone from the captured analysis sound; and determining a reflection component for the specific frequency of the tone; adjusting the gain in frequency-specific manner and based on the determined reflection component.Type: ApplicationFiled: July 4, 2012Publication date: July 10, 2014Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Erich Goll, Ernst Dalhoff, Hans-Peter Zenner
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Patent number: 8691183Abstract: The present invention relates to a composition for the detection and the treatment of prostate cells and to methods for the diagnostic and therapeutic treatment of a human being using the composition according to the invention.Type: GrantFiled: February 8, 2011Date of Patent: April 8, 2014Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventor: Stefan Heckl
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Patent number: 8618178Abstract: The invention relates to methods for treating T cell mediated autoimmune diseases, such as psoriasis and multiple sclerosis, in a human in need thereof, wherein a therapeutically effective amount of a substance which lowers the cellular glutathione content is administered to the human.Type: GrantFiled: May 28, 2009Date of Patent: December 31, 2013Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Martin Roecken, Kamran Ghoreschi, Christina Mathilde Weigert
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Publication number: 20130331906Abstract: The present invention relates to a method of treating movement disorders of a living being, a method of treating refractory gait disturbances of a human Parkinson's disease patient being affected by gait disturbances, and an apparatus for deep brain stimulation (DBS) of a living being affected by movement disorders.Type: ApplicationFiled: June 11, 2012Publication date: December 12, 2013Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Rejko Krueger, Daniel Weiss
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Publication number: 20130122078Abstract: The present invention relates to a method for the implantation of biological material into an organism.Type: ApplicationFiled: January 4, 2013Publication date: May 16, 2013Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventor: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
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Publication number: 20130108580Abstract: The present invention relates to a fusion protein comprising a) a first polypeptide selected from among SDF-1 (stromal cell derived factor-1) or peptidase/protease-resistant variants or fragments thereof which have the CXCR4-/CXCR7- binding function of SDF-1; and b) a second polypeptide which is selected from among GPVI (glycoprotein VI), or the extracellular domain of GPVI, or fragments or variants of the extracellular domain of GPVI which contain the collagen binding function of GPVI, wherein the first polypeptide and the second peptide are linked to one another directly or via a linker molecule. The invention furthermore relates to the use of the fusion protein for treating diseases.Type: ApplicationFiled: September 28, 2012Publication date: May 2, 2013Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventor: Eberhard-Karls-Universitaet Tuebingen Universita
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Publication number: 20130078219Abstract: The present invention relates to a genetically modified Paramyxovirus, a pharmaceutical composition comprising this paramyxovirus, the use of a genetically modified Paramyxovirus for the therapeutic and/or prophylactic treatment of a tumor disease, and a method for the production of a pharmaceutical composition for the therapeutic or prophylactic treatment of a tumor disease.Type: ApplicationFiled: October 22, 2012Publication date: March 28, 2013Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventor: Eberhard-Karls-Universitaet Tuebingen Universitaet
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Publication number: 20130078648Abstract: The present invention relates to a method for the visual examination of biological material ex vivo and an apparatus for the sterical orientation of biological material which can be used in said method.Type: ApplicationFiled: November 16, 2012Publication date: March 28, 2013Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventor: Eberhard-Karls-Universitaet Tuebingen Universita
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Patent number: 8163495Abstract: The present invention concerns antibodies produced from hybridoma cell lines chosen from the group comprising W8B2, W1C3, W7C6, W5C4, 24D2, 28D4, HEK-3D6, W4A5, W3D5, W5C5, 9A3G9, 58B1, F9-3C2F1, 39D5, for isolating and/or identifying homogenous mesenchymal stem cells. Furthermore a method is presented with which mesenchymal stem cells from adult primary tissue, for example bone marrow, can be identified and isolated with a high level of purity.Type: GrantFiled: September 11, 2007Date of Patent: April 24, 2012Assignee: Eberhard-Karls-Universität Tuebingen UniversitaetsklinikumInventors: Hans-Jorg Buhring, Reiner Lammers, Sabrina Treml, Venkata Lokesh Battula
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Patent number: 8143223Abstract: The present invention relates to a method for protecting biological material from cell damaging factors, a method for producing a pharmaceutical composition for the prophylactic and/or therapy accompanying treatment of radiation therapy patients and/or chemotherapy patients, a cosmetic composition, and a culture medium.Type: GrantFiled: October 2, 2003Date of Patent: March 27, 2012Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Klaus Dittmann, Claus Mayer, Peter Rodemann
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Publication number: 20110165065Abstract: The present invention relates to a composition for the detection and the treatment of prostate cells and to methods for the diagnostic and therapeutic treatment of a human being using the composition according to the invention.Type: ApplicationFiled: February 8, 2011Publication date: July 7, 2011Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventor: Stefan Heckl