Patents Assigned to Eberhard-Karls-Universität Tübingen
-
Publication number: 20130108580Abstract: The present invention relates to a fusion protein comprising a) a first polypeptide selected from among SDF-1 (stromal cell derived factor-1) or peptidase/protease-resistant variants or fragments thereof which have the CXCR4-/CXCR7- binding function of SDF-1; and b) a second polypeptide which is selected from among GPVI (glycoprotein VI), or the extracellular domain of GPVI, or fragments or variants of the extracellular domain of GPVI which contain the collagen binding function of GPVI, wherein the first polypeptide and the second peptide are linked to one another directly or via a linker molecule. The invention furthermore relates to the use of the fusion protein for treating diseases.Type: ApplicationFiled: September 28, 2012Publication date: May 2, 2013Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventor: Eberhard-Karls-Universitaet Tuebingen Universita
-
Patent number: 8409809Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.Type: GrantFiled: August 26, 2011Date of Patent: April 2, 2013Assignees: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Eberhard-Karls-Universitaet Tuebingen, Mayo Foundation For Medical Education and ResearchInventors: Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Johannes Gloeckner, Thomas Gasser, Petra Herzig, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
-
Publication number: 20130078219Abstract: The present invention relates to a genetically modified Paramyxovirus, a pharmaceutical composition comprising this paramyxovirus, the use of a genetically modified Paramyxovirus for the therapeutic and/or prophylactic treatment of a tumor disease, and a method for the production of a pharmaceutical composition for the therapeutic or prophylactic treatment of a tumor disease.Type: ApplicationFiled: October 22, 2012Publication date: March 28, 2013Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventor: Eberhard-Karls-Universitaet Tuebingen Universitaet
-
Publication number: 20130078648Abstract: The present invention relates to a method for the visual examination of biological material ex vivo and an apparatus for the sterical orientation of biological material which can be used in said method.Type: ApplicationFiled: November 16, 2012Publication date: March 28, 2013Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventor: Eberhard-Karls-Universitaet Tuebingen Universita
-
Patent number: 8168160Abstract: The present invention relates to a fusion protein comprising therapeutic and diagnostic potential against chronic vascular diseases, such as atherosclerosis, a nucleic acid molecule encoding said fusion protein, a pharmaceutical and diagnostic composition which comprises the fusion protein or the nucleic acid molecule, the use of the fusion protein or the nucleic acid molecule for the production of a pharmaceutical and diagnostic composition, a method for the diagnosis of acute or chronic vascular diseases, and a method for the production of a fusion protein.Type: GrantFiled: November 17, 2008Date of Patent: May 1, 2012Assignee: Eberhard-Karls-Universität TübingenInventors: Meinrad Gawaz, Karin Daub
-
Patent number: 8163495Abstract: The present invention concerns antibodies produced from hybridoma cell lines chosen from the group comprising W8B2, W1C3, W7C6, W5C4, 24D2, 28D4, HEK-3D6, W4A5, W3D5, W5C5, 9A3G9, 58B1, F9-3C2F1, 39D5, for isolating and/or identifying homogenous mesenchymal stem cells. Furthermore a method is presented with which mesenchymal stem cells from adult primary tissue, for example bone marrow, can be identified and isolated with a high level of purity.Type: GrantFiled: September 11, 2007Date of Patent: April 24, 2012Assignee: Eberhard-Karls-Universität Tuebingen UniversitaetsklinikumInventors: Hans-Jorg Buhring, Reiner Lammers, Sabrina Treml, Venkata Lokesh Battula
-
Patent number: 8143223Abstract: The present invention relates to a method for protecting biological material from cell damaging factors, a method for producing a pharmaceutical composition for the prophylactic and/or therapy accompanying treatment of radiation therapy patients and/or chemotherapy patients, a cosmetic composition, and a culture medium.Type: GrantFiled: October 2, 2003Date of Patent: March 27, 2012Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Klaus Dittmann, Claus Mayer, Peter Rodemann
-
Publication number: 20120035072Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.Type: ApplicationFiled: August 26, 2011Publication date: February 9, 2012Applicants: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH, Mayo Foundation for Medical Education and Research, Eberhard Karls Universitaet TuebingenInventors: Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Johannes Gloeckner, Thomas Gasser, Petra (Leitner) Herzig, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
-
Patent number: 8029986Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.Type: GrantFiled: September 27, 2005Date of Patent: October 4, 2011Assignees: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt(GmbH), Eberhard Karls Universitaet Tuebingen, Mayo Foundation for Medical Education and ResearchInventors: Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Johannes Gloeckner, Thomas Gasser, Petra Herzig, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
-
Publication number: 20110165065Abstract: The present invention relates to a composition for the detection and the treatment of prostate cells and to methods for the diagnostic and therapeutic treatment of a human being using the composition according to the invention.Type: ApplicationFiled: February 8, 2011Publication date: July 7, 2011Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventor: Stefan Heckl
-
Patent number: 7939266Abstract: The present invention relates to a therapeutic or/and diagnostic substance. Furthermore it relates to an expression vector, to a composition comprising the afore-mentioned substance or/and the afore-mentioned expression vector, a method for diagnosing a tumor disease or/and an infectious disease in a living being, as well as to a method for the treatment of a tumor disease or/and of an infection in a living being.Type: GrantFiled: October 8, 2004Date of Patent: May 10, 2011Assignee: Eberhard-Karls-Universität Tübingen UniversitätsklinikumInventors: Gernot Stuhler, Helmut Salih
-
Publication number: 20110070627Abstract: The present invention relates to a composition for the cultivation of sophisticated bacteria, preferably of the genus Bartonella, and to a method for the cultivation of these bacteria.Type: ApplicationFiled: October 25, 2010Publication date: March 24, 2011Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventor: Volkhard Kempf
-
Patent number: 7854951Abstract: The present invention relates to a method for treating milk, preferably breast milk, in which the milk is briefly heated in a container, said method comprising the following steps: The container is moved, preferably set in rotation, so that a milk film forms on its inner wall, the milk is heated to a treatment temperature during a heating phase, the milk is maintained at the treatment temperature for a treatment period of less than 20 seconds, and the milk is cooled to room temperature.Type: GrantFiled: September 15, 2006Date of Patent: December 21, 2010Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Klaus Hamprecht, Klaus Lauf
-
Publication number: 20100247432Abstract: The present invention relates to a method for diagnosing peritoneal carcinoses or metastatic primary tumors in a subject, as well as to a method for providing a prognosis to a subject diagnosed with a primary tumor to develop metastases, in particular peritoneal carcinosis, comprising the step of determining the level of expression of at least phosphoglycerate kinase 1 (PGK1) gene. Further, the invention relates to a diagnostic kit, comprising at least one substance for detection of the activity and/or expression of phosphoglycerate kinase 1 (PGK1) and/or ?-catenin, either alone or in combination with the detection of CXCR4 and/or CXCL12, for the diagnosis or prognosis of peritoneal carcinoses and/or metastatic primary tumors.Type: ApplicationFiled: April 2, 2010Publication date: September 30, 2010Applicant: EBERHARD-KARLS-UNIVERSITAET TUEBINGENInventor: DEREK ZIEKER
-
Publication number: 20100235933Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.Type: ApplicationFiled: September 27, 2005Publication date: September 16, 2010Applicants: Mayo Clinic, GSF Forschungszentrum fuer umwelt und Gesundheit GmbH, Eberhard Karls Universitaet TuebingenInventors: Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Gloeckner, Thomas Gasser, Petra Leitner, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
-
Patent number: 7754259Abstract: A method for treating milk, wherein milk is short-term heated in a container. At least during the heating, the container is set in motion in such a way that a milk film forms on the inner wall of the container. A device for carrying out the method is likewise described (FIG. 1).Type: GrantFiled: December 16, 2005Date of Patent: July 13, 2010Assignee: Eberhard-Karls-Universität Tübingen UniversitätsklinikumInventors: Gerhard Jahn, Christian P. Speer, Jens Maschmann, Klaus Hamprecht, Klaus Lauf
-
Publication number: 20100068145Abstract: The present invention relates to a bispecific fusion protein, comprising (a) a first polypeptide which binds to collagen, and (b) a second polypeptide which binds to endothelial precursor cells. Also, pharmaceutical compositions are disclosed, comprising the fusion protein of the invention, as well as methods for using the fusion protein, in particular for treating or preventing lesions of vessels and tissues.Type: ApplicationFiled: August 20, 2009Publication date: March 18, 2010Applicant: Eberhard-Karls-Universitaet TuebingenInventors: Harald Langer, Meinrad Gawaz, Hans-Jorg Buhring, Thomas Skutella, Gundram Jung
-
Patent number: 7659116Abstract: The present invention relates to a monoclonal antibody or fragment thereof, which binds specifically and/or selectively to human receptors of the Frizzled (FZD) family. It further relates to a hybridoma cell that produces the antibody according to the invention. Another object of the present invention is a method for the detection and/or isolation of receptors of the FZD family or homologs or fragments thereof in a biological sample and a method for the identification and/or isolation of biological material comprising or expressing receptors of the FZD family or homologs or fragments thereof. The invention further relates to the use of the antibody according to the invention or fragments thereof for the specific and/or selective detection and/or isolation of receptors of the FZD family, a composition comprising the monoclonal antibody according to the invention or fragments thereof, and a kit comprising the monoclonal antibody according to the invention or fragments thereof.Type: GrantFiled: April 12, 2007Date of Patent: February 9, 2010Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Hans-Joerg Buehring, Sigrid Hojak, Ingrid Albert
-
Publication number: 20090124546Abstract: An antimicrobially active peptide comprises the DCD protein or a fragment of DCD, preferably derived from the C-terminal region.Type: ApplicationFiled: March 6, 2008Publication date: May 14, 2009Applicant: EBERHARD-KARLS-UNIVERSITAET TUEBINGEN UNIVERSITAETSKILINIKUMInventors: Claus Garbe, Birgit Schittek
-
Publication number: 20090023194Abstract: The present invention relates to a device and a method for the cultivation and generation of biological material.Type: ApplicationFiled: June 12, 2008Publication date: January 22, 2009Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Timo Schmidt, Lothar Just