Patents Assigned to Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
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Patent number: 7939266Abstract: The present invention relates to a therapeutic or/and diagnostic substance. Furthermore it relates to an expression vector, to a composition comprising the afore-mentioned substance or/and the afore-mentioned expression vector, a method for diagnosing a tumor disease or/and an infectious disease in a living being, as well as to a method for the treatment of a tumor disease or/and of an infection in a living being.Type: GrantFiled: October 8, 2004Date of Patent: May 10, 2011Assignee: Eberhard-Karls-Universität Tübingen UniversitätsklinikumInventors: Gernot Stuhler, Helmut Salih
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Publication number: 20110070627Abstract: The present invention relates to a composition for the cultivation of sophisticated bacteria, preferably of the genus Bartonella, and to a method for the cultivation of these bacteria.Type: ApplicationFiled: October 25, 2010Publication date: March 24, 2011Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventor: Volkhard Kempf
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Patent number: 7854951Abstract: The present invention relates to a method for treating milk, preferably breast milk, in which the milk is briefly heated in a container, said method comprising the following steps: The container is moved, preferably set in rotation, so that a milk film forms on its inner wall, the milk is heated to a treatment temperature during a heating phase, the milk is maintained at the treatment temperature for a treatment period of less than 20 seconds, and the milk is cooled to room temperature.Type: GrantFiled: September 15, 2006Date of Patent: December 21, 2010Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Klaus Hamprecht, Klaus Lauf
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Patent number: 7754259Abstract: A method for treating milk, wherein milk is short-term heated in a container. At least during the heating, the container is set in motion in such a way that a milk film forms on the inner wall of the container. A device for carrying out the method is likewise described (FIG. 1).Type: GrantFiled: December 16, 2005Date of Patent: July 13, 2010Assignee: Eberhard-Karls-Universität Tübingen UniversitätsklinikumInventors: Gerhard Jahn, Christian P. Speer, Jens Maschmann, Klaus Hamprecht, Klaus Lauf
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Patent number: 7659116Abstract: The present invention relates to a monoclonal antibody or fragment thereof, which binds specifically and/or selectively to human receptors of the Frizzled (FZD) family. It further relates to a hybridoma cell that produces the antibody according to the invention. Another object of the present invention is a method for the detection and/or isolation of receptors of the FZD family or homologs or fragments thereof in a biological sample and a method for the identification and/or isolation of biological material comprising or expressing receptors of the FZD family or homologs or fragments thereof. The invention further relates to the use of the antibody according to the invention or fragments thereof for the specific and/or selective detection and/or isolation of receptors of the FZD family, a composition comprising the monoclonal antibody according to the invention or fragments thereof, and a kit comprising the monoclonal antibody according to the invention or fragments thereof.Type: GrantFiled: April 12, 2007Date of Patent: February 9, 2010Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Hans-Joerg Buehring, Sigrid Hojak, Ingrid Albert
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Publication number: 20090023194Abstract: The present invention relates to a device and a method for the cultivation and generation of biological material.Type: ApplicationFiled: June 12, 2008Publication date: January 22, 2009Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Timo Schmidt, Lothar Just
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Publication number: 20080267955Abstract: The present invention relates to a method for treating and a method for identifying a tumor of a human or animal comprising administering composition comprising an agent which binds to Frizzled 9.Type: ApplicationFiled: January 24, 2008Publication date: October 30, 2008Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Hermann Schluesener, Hans-Jorg Buhring, Sigrid Hojak, Ingrid Albert
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Patent number: 7364863Abstract: The invention relates to a monoclonal antibody, or fragments thereof, for isolating and/or identifying mesenchymal stem cells. In this connection, the antibody, or fragments thereof, bind to an antigen which is the same as that bound to by an antibody which is produced by the hybridoma cell line W8B2, which was deposited on 14.08.2002 in the DSMZ [German collection of microorganisms and cell cultures] under the number DSM ACC2567.Type: GrantFiled: March 9, 2005Date of Patent: April 29, 2008Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Hans-Jorg Buhring, Reiner Lammers, Wichard Vogel
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Publication number: 20080069772Abstract: The present invention relates to a therapeutic or/and diagnostic substance. Furthermore it relates to an expression vector, to a composition comprising the afore-mentioned substance or/and the afore-mentioned expression vector, a method for diagnosing a tumor disease or/and an infectious disease in a living being, as well as to a method for the treatment of a tumor disease or/and of an infection in a living being.Type: ApplicationFiled: February 22, 2007Publication date: March 20, 2008Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Gernot Stuhler, Helmut Salih
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Patent number: 7235364Abstract: The present invention relates to a method for diagnosing hypertension, and/or allergy, and/or hair loss, and/or liabilty for infection, of a human being, or a predisposition therefor; to a nucleic acid molecule coding for a human ClCKb protein comprising a genetic alteration at amino acid position 481 compared to the wild type, as well as for corresponding segments thereof; to a nucleic acid molecule which binds to the before-mentioned nucleic acid molecule under stringent conditions, as well as to a nucleic acid molecule which binds to that nucleic acid molecule; to a (poly)peptide encoded by the afore-mentioned nucleic acid molecules; to a method for identifying substances modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to a substance for modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to methods for preparing a pharmaceutType: GrantFiled: April 4, 2006Date of Patent: June 26, 2007Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Florian Lang, Siegfried Waldegger, Philipp Lang, Angelika Lampert, Hannsjoerg Seybert, Nikola Jeck
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Patent number: 7229410Abstract: A method and a device are used for determining a characteristic value for the perfusion of modified, in particular pigmented tissue regions in organs of living beings, for example the skin. By means of a laser flowmeter, a first volumetric flow rate and a second volumetric flow rate of the blood are determined at a first measurement point and at a second measurement point, respectively within the modified tissue region and within the surrounding, unmodified tissue region, in each case as a measurement profile of a volumetric flow rate signal as a function of time. A wavelet analysis of each of the measurement profiles is then carried out as a three-dimensional representation of the signal intensity over a frequency or scaling axis and time.Type: GrantFiled: February 17, 2004Date of Patent: June 12, 2007Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Kurt Braeuer, Hans-Martin Haefner
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Patent number: 7182946Abstract: The present invention relates to mono clonal antibodies or fragments thereof for isolating and/or identifying neural progenitor cells. The antibodies or fragments thereof bind to an identical antigen as an antibody which is produced by the hybridoma cell lines W4A5, W8C3 and 57D2 deposited on Aug. 14, 2002, at the Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ) under the numbers DSM ACC2571, DSM ACC2570 and DSM ACC2568.Type: GrantFiled: March 9, 2005Date of Patent: February 27, 2007Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Hans-Joerg Buehring, Wichard Vogel
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Publication number: 20060172997Abstract: A method for treating viral diseases which are caused by DNA viruses is described comprising administering an effective amount of at least one inhibitor of reverse transcriptase (RTI) in combination with at least one inhibitor of viral DNA polymerase, wherein the at least one RTI and the at least one DNA polymerase inhibitor are present in the form of separate compounds.Type: ApplicationFiled: November 3, 2005Publication date: August 3, 2006Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Klaus Hamprecht, Herbert Schott, Elfriede Mikeler, Gerhard Jahn
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Patent number: 7074573Abstract: The present invention relates to a method for diagnosing hypertension, and/or allergy, and/or hair loss, and/or liability for infection, of a human being, or a predisposition therefor; to a nucleic acid molecule coding for a human ClCKb protein comprising a genetic alteration at amino acid position 481 compared to the wild type, as well as for corresponding segments thereof; to a nucleic acid molecule which binds to the before-mentioned nucleic acid molecule under stringent conditions, as well as to a nucleic acid molecule which binds to that nucleic acid molecule; to a (poly)peptide encoded by the afore-mentioned nucleic acid molecules; to a method for identifying substances modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to a substance for modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to methods for preparing a pharmaceuType: GrantFiled: October 15, 2003Date of Patent: July 11, 2006Assignee: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Florian Lang, Siegfried Waldegger, Phillipp Lang, Angelika Lampert, Hannsjoerg Seybert, Nikola Jeck
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Publication number: 20060068416Abstract: Devices having at least one surface which comes into contact with tissues and/or fluids of the human or animal body. These surfaces are at least partially coated with aptamers, which mediate the adhesion of biological material.Type: ApplicationFiled: June 13, 2005Publication date: March 30, 2006Applicant: Eberhard-Karls-Universitaet Tuebingen UniversitaetsklinikumInventors: Hermann Schluesener, Hans-Peter Wendel
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Patent number: 6761724Abstract: An operation kit is provided for access into the subretinal region of the eye. The kit comprises an elongated flat body of soft material, which can be inserted into the subretinal region from the side through an incision in the sclera. The body is formed as a strip, whose one surface is configured as a guiding surface for a medical device, for example for implanting a microphotodiode chip.Type: GrantFiled: March 20, 2000Date of Patent: July 13, 2004Assignee: Eberhard-Karls-Universität Tübingen UniversitätsklinikumInventors: Eberhart Zrenner, Veit-Peter Gabel, Karin Kobuch
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Patent number: 6605439Abstract: For the detection of fungal cells in clinical material fungal DNA is extracted from whole blood and the extracted fungal DNA is then detected. From this detection, a fungal infection can be concluded. For further diagnosis, the fungal species are then determined from the extracted fungal DNA. The method for extraction of the fungal DNA from whole blood comprises the isolation of predominantly intact fungal cells from the whole blood and the extraction of DNA from the isolated fungal cells. For detection of fungal DNA, at least one segment of the fungal DNA to be detected is amplified, then the amplification products are detected. For further identification of the fungal species, nucleotide sequence segments being characteristic for the fungal species are detected.Type: GrantFiled: May 29, 2001Date of Patent: August 12, 2003Assignee: Eberhard-Karls Universität Tübingen UniversitätsklinikumInventor: Hermann Einsele